Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum

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Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...737648F
P356DOI10.1371/JOURNAL.PONE.0037648
P932PMC publication ID3356285
P698PubMed publication ID22624058
P5875ResearchGate publication ID225059709

P50authorBarton HaynesQ4865631
Guido FerrariQ56481169
Garnett KelsoeQ60614752
Georgia D. TomarasQ63663866
M Anthony MoodyQ73297881
Sallie R PermarQ87955622
Genevieve G FoudaQ88408572
Hua-Xin LiaoQ88608388
Munir AlamQ89520930
Kara AnastiQ89520956
Shi-Mao XiaQ114423501
Justin PollaraQ114519514
P2093author name stringGuang Yang
Xiaoying Shen
James Friedman
Shelley Stewart
P2860cites workNonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigensQ42170072
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Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entryQ43694761
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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infectionQ45744790
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Fc receptor but not complement binding is important in antibody protection against HIV.Q46545827
Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodiesQ47765150
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HIV-1 autoreactive antibodies: are they good or bad for HIV-1 prevention?Q64934974
Chemotaxis as a mechanism for recruitment of mucosal plasma cell precursorsQ68833882
The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequencesQ73927391
An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120Q80473704
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsQ24635002
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1Q24645530
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120Q27643185
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responsesQ28242631
Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41Q28646771
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccinationQ28743596
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexesQ30706865
qpcR: an R package for sigmoidal model selection in quantitative real-time polymerase chain reaction analysisQ30843566
SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinationsQ33229588
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titersQ33444658
HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysisQ33479955
Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptidesQ33560772
Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokinesQ33794973
Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.Q33809112
Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sortingQ34042758
Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeysQ34046182
Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeysQ34474475
B cell responses to HIV-1 infection and vaccination: pathways to preventing infectionQ34645502
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremiaQ34848486
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-LQ35012462
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serumQ35077677
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaquesQ35101333
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodiesQ35116581
HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodiesQ35192641
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedQ35441583
A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary virusesQ35569049
Origin of IgA-secreting plasma cells in the mammary glandQ36336203
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 bindingQ36649958
Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeysQ36996108
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoproteinQ37742876
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Q40429324
Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissuesQ41632896
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
P304page(s)e37648
P577publication date2012-05-18
P1433published inPLOS OneQ564954
P1476titleIsolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum
P478volume7

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cites work (P2860)
Q54263363Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay.
Q92177871Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models
Q40410573Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.
Q33743734CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies
Q57177123Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV
Q37426168Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses
Q64062657HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells
Q35728947HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies
Q27022055HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design
Q39250593How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design
Q33620546Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection
Q35861276Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission
Q35872338Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women
Q36588632Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants
Q35058698Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women
Q24598653Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk
Q35737800The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells
Q35914306Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
Q33772637Which Antibody Functions are Important for an HIV Vaccine?

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