Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1).

scientific article

Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1). is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1050827505
P356DOI10.1038/APS.2011.163
P932PMC publication ID4010328
P698PubMed publication ID22158108
P5875ResearchGate publication ID51868151

P2093author name stringLin Zhao
Yang Jiao
Sai-jun Fan
Li-li Wang
Jia-ying Xu
Ke-kang Sun
P2860cites workGlobal cancer statisticsQ22241238
Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activityQ24311733
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.Q27851616
Negative regulation of BMP/Smad signaling by Tob in osteoblastsQ28143428
Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancerQ28187810
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signalingQ28208130
The mammalian anti-proliferative BTG/Tob protein familyQ28258172
PI3K/PTEN signaling in angiogenesis and tumorigenesisQ28383083
Metastasis suppressor genes at the interface between the environment and tumor cell growthQ28394526
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activityQ30434033
Oncogenes and tumor suppressor genesQ34149922
A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathwayQ34535107
Intervening in β-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasisQ34551546
Mice lacking a transcriptional corepressor Tob are predisposed to cancerQ35965343
Tob genes in development and homeostasisQ36737268
PTEN, more than the AKT pathwayQ36753139
PTEN mutation: many birds with one stone in tumorigenesis.Q37384428
Tob, a member of the APRO family, regulates immunological quiescence and tumor suppressionQ37409167
Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC.Q37439082
BTG/TOB factors impact deadenylasesQ37455743
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.Q37582684
Generation of tolerogenic dendritic cells via the E-cadherin/beta-catenin-signaling pathwayQ37601348
Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasionQ37690802
Lung cancer progression and metastasis from the prognostic point of view.Q37708137
Molecular mechanism of pancreatic cancer--understanding proliferation, invasion, and metastasisQ37711135
Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to gamma-irradiationQ37727961
Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitroQ37728188
Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathwayQ37780773
Regulation of VSMC behavior by the cadherin-catenin complex.Q37825170
Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and InvasionQ38341405
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitroQ38590785
Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells.Q39682416
Effect of wild type PTEN gene on proliferation and invasion of multiple myelomaQ39687681
TOB suppresses breast cancer tumorigenesisQ39830658
TOB1 is regulated by EGF-dependent HER2 and EGFR signaling, is highly phosphorylated, and indicates poor prognosis in node-negative breast cancerQ39843653
Tumor growth suppression by adenovirus-mediated introduction of a cell-growth-suppressing gene tob in a pancreatic cancer modelQ39957051
Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinomaQ42453448
Tob is a potential marker gene for the basal layer of the epidermis and is stably expressed in human primary keratinocytesQ42490158
Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinomaQ42805237
Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasionQ42979728
A nonreplicating adenoviral vector that contains the wild-type p53 transgene combined with chemotherapy for primary breast cancer: safety, efficacy, and biologic activity of a novel gene-therapy approachQ45861413
Both lipid- and protein-phosphatase activities of PTEN contribute to the p53-PTEN anti-invasion pathwayQ45908947
Molecular mechanisms of metastasis.Q46055814
Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patientsQ46710025
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.Q47073575
Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression.Q47435485
Dihydroartemisinin is an inhibitor of ovarian cancer cell growthQ47776445
The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learningQ48686904
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.Q53486364
Molecular alterations of E-cadherin and beta-catenin in brain metastases.Q54394542
The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases.Q54650775
EGFR and HER3 mRNA expression levels predict distant metastases in locally advanced rectal cancerQ54651225
Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiationQ64376960
Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolutionQ80087614
Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroidQ81520552
PI(3)K/PTEN/AKT pathwayQ82943406
P433issue2
P921main subjectlung cancerQ47912
P304page(s)250-260
P577publication date2011-12-12
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleSuppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1).
P478volume33

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cites work (P2860)
Q55356398Association between the SNPs of the TOB1 gene and gastric cancer risk in the Chinese Han population of northeast China.
Q45845716Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer
Q88778854Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension
Q47957465Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus
Q36360773Influence of nanoparticle-mediated transfection on proliferation of primary immune cells in vitro and in vivo
Q34583846Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line
Q87417424MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival
Q93187723Phosphorylation of TOB1 at T172 and S320 is critical for gastric cancer proliferation and progression
Q36277982Progesterone regulates the proliferation of breast cancer cells - in vitro evidence
Q92348278TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer
Q36633354The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro
Q38819414The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer
Q38834886Tob1 enhances radiosensitivity of breast cancer cells involving the JNK and p38 pathways
Q36639904Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling
Q26773429Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective
Q42416926Transducer of erbB2.1 is a potential cellular target of gefitinib in lung cancer therapy
Q42260667miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice.

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