Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant

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Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084912445
P356DOI10.1038/SREP46535
P932PMC publication ID5394481
P698PubMed publication ID28417960

P2093author name stringScott R Kennedy
Alan J Herr
Jill McKay-Fleisch
Daniel G Dennis
Ian Dowsett
Kaila Eitzen
P2860cites workStructural basis of high-fidelity DNA synthesis by yeast DNA polymerase deltaQ24601494
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The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replicationQ27933493
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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressorQ27935222
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DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in miceQ37386020
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Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastropheQ37678547
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MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Q42602158
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Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stallQ43189813
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptaseQ46193418
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Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase deltaQ46848079
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DUN1 encodes a protein kinase that controls the DNA damage response in yeastQ48087375
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.Q54639795
Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutQ56944626
Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alphaQ69293401
Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stabilityQ71081409
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
Defective DNA polymerase-delta proofreading causes cancer susceptibility in miceQ73954766
Mutational meltdown in laboratory yeast populationsQ74112270
COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF ESCHERICHIA COLIQ88206326
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)46535
P577publication date2017-04-18
P1433published inScientific ReportsQ2261792
P1476titleNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant
P478volume7

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Q52681774Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.cites workP2860

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