Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition

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Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition is …
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scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1275723E
P356DOI10.1371/JOURNAL.PONE.0175723
P932PMC publication ID5395182
P698PubMed publication ID28419165

P50authorFrançois DiederichQ692634
Klaus ReuterQ55163316
P2093author name stringAndreas Heine
Johann Stojko
Sarah Cianférani
François Debaene
Alexander Metz
Gerhard Klebe
Luzi Jakob Barandun
Frederik Rainer Ehrmann
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectalternative factsQ28478874
P304page(s)e0175723
P577publication date2017-04-18
P1433published inPLOS OneQ564954
P1476titleSoaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition
P478volume12

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cites work (P2860)
Q58587192Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway
Q91753299Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies
Q97425851New Palladium(II) and Platinum(II) Complexes Based on Pyrrole Schiff Bases: Synthesis, Characterization, X-ray Structure, and Anticancer Activity
Q47717493Principles and methods used to grow and optimize crystals of protein-metallodrug adducts, to determine metal binding sites and to assign metal ligands.
Q89920708Protein X-ray Crystallography and Drug Discovery
Q100493872Two Methods, one Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses
Q108146970X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

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