Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway

scientific article published in June 2009

Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/0008-5472.CAN-08-4194
P932PMC publication ID2804866
P698PubMed publication ID19487288

P50authorInes BaroneQ59688868
P2093author name stringAmanda Beyer
Jennifer Selever
Matthew H Herynk
Suzanne A W Fuqua
Sebastiano Andò
Cinzia Giordano
Yukun Cui
Arnoldo Corona-Rodriguez
P2860cites workpp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167Q24533505
Hypersensitive K303R oestrogen receptor-alpha variant not found in invasive carcinomasQ24796885
The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based studyQ25257794
The consensus coding sequences of human breast and colorectal cancersQ27861035
Patterns of somatic mutation in human cancer genomesQ29547841
Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivoQ30304578
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
The activation of Akt/PKB signaling pathway and cell survival.Q34405519
Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer.Q34578381
Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancerQ35049854
What do we know about the mechanisms of aromatase inhibitor resistance?Q35691554
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.Q35786706
Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancerQ35794355
AKT/PKB signaling mechanisms in cancer and chemoresistanceQ35966433
Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapyQ35991001
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptorQ39971693
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cellsQ40195766
Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model.Q40383001
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozoleQ40408917
The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivationQ40427640
Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.Q40479849
Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistanceQ40536641
Estrogen receptor alpha (ESR1) mutant A908G is not a common feature in benign and malignant proliferations of the breastQ40575607
Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogensQ40614262
Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell linesQ41198739
Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cellsQ41291278
Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activationQ41859532
Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivationQ42442143
Short- and long-term estrogen deprivation of T47D human breast cancer cells in cultureQ42815851
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.Q43708526
No hypersensitive estrogen receptor-alpha mutation (K303R) in Japanese breast carcinomasQ44803003
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family membersQ45267497
A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancerQ46586619
Adjuvant aromatase inhibitors for breast cancerQ46638001
Aromatase inhibitors--a triumph of translational oncologyQ46871157
Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.Q52276783
The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling.Q52514375
Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer.Q54172521
Estrogen receptor alpha mutation (A-to-G transition at nucleotide 908) is not found in different types of breast lesions from Japanese women.Q54795647
45 Assay of aromatase activityQ67842856
Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablationQ67982627
A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesionsQ74181062
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
P304page(s)4724-4732
P577publication date2009-06-01
P1433published inCancer ResearchQ326097
P1476titleExpression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway
P478volume69

Reverse relations

cites work (P2860)
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