Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression

scientific article published on April 18, 2011

Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009439533
P356DOI10.1038/ONC.2011.124
P953full work available at URLhttps://doi.org/10.1038/onc.2011.124
https://europepmc.org/articles/PMC4482257
https://europepmc.org/articles/PMC4482257?pdf=render
https://www.nature.com/articles/onc2011124
https://www.nature.com/articles/onc2011124.pdf
P932PMC publication ID4482257
P698PubMed publication ID21499302
P5875ResearchGate publication ID51057146

P50authorPietro RizzaQ56516232
Daniela BonofiglioQ56516237
Stefania CatalanoQ56516243
Ines BaroneQ59688868
Luca GelsominoQ87908276
Suzanne A W FuquaQ88598563
P2093author name stringC. Giordano
S. Andò
S. Panza
D. Vizza
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Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor αQ28308069
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cellsQ28571177
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cellsQ29547557
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Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness.Q30986520
Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathwayQ33583914
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancerQ34181456
Measurement of steroid hormone receptors in breast cancer patients on tamoxifenQ34345668
Biology of HER2 and its importance in breast cancerQ34428745
Characterization of the promoter region of the human c-erbB-2 protooncogeneQ34633898
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response elementQ34790389
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.Q35786706
Tamoxifen--what next?Q35841960
FXR as a novel therapeutic target for vascular diseaseQ35987252
Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapyQ35991001
Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistanceQ36860992
Enhancing the efficacy of hormonal agents with selected targeted agentsQ37533801
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.Q38300264
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptorQ38313790
The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesisQ38315886
Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promotersQ38337562
Resistance to tamoxifen‐induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancerQ39411673
G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cellsQ39800227
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activationQ40164157
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cellsQ40195766
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expressionQ40218920
Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model.Q40383001
The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivationQ40427640
Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistanceQ40536641
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancerQ40544950
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cellsQ40670668
Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancerQ41090487
Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.Q43607758
Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytesQ44356501
Amplified in breast cancer 1 in human epidermal growth factor receptor - positive tumors of tamoxifen-treated breast cancer patientsQ44825601
HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group studyQ45050365
Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinaseQ45309214
P433issue39
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
tamoxifenQ412178
Erb-b2 receptor tyrosine kinase 2Q415271
P304page(s)4129-4140
P577publication date2011-04-18
P1433published inOncogeneQ1568657
P1476titleFarnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression
P478volume30

Reverse relations

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