Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression

scientific article

Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.15348
P8608Fatcat IDrelease_5xqlwvewl5hirlfoqdhylqs3rm
P932PMC publication ID5400552
P698PubMed publication ID28209916

P50authorVicente A TorresQ64764422
Rafaela EricesQ84329119
Renan OrellanaQ85322532
Gareth I OwenQ92421599
Galdo BustosQ95949488
Sofía CubillosQ115314190
P2093author name stringSumie Kato
Monica Marquez
Jaime Pereira
Alejandro S Godoy
Bárbara Oliva
Carolina Ibañez
Carolina Ramírez
Catalina Alonso
Clemente Arab
Erasmo Bravo
Felice Santoro
Jorge Brañes
Julio Cesar Cardenas
Karen García
María Loreto Bravo
Mauricio A Cuello
Pamela González
Patricia Fuenzalida
Raúl Aravena
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
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Platelet granule secretion continuously prevents intratumor hemorrhageQ30483704
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cellsQ30576959
The physiology of platelet productionQ33334397
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhageQ33369958
Establishment of a Database of Metformin Plasma Concentrations and Erythrocyte Levels in Normal and Emergency SituationsQ33845157
Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).Q33946957
Platelets guide the formation of early metastatic nichesQ34002250
Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathwayQ34040261
Effect of metformin on serum interleukin-6 levels in polycystic ovary syndrome: a systematic reviewQ34109435
In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanismQ34215849
Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumorsQ34442318
Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.Q34887704
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion currentQ34957274
Evidence that platelets promote tube formation by endothelial cells on matrigel.Q35028157
Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathwayQ35029506
Compound C Inhibits Vascular Smooth Muscle Cell Proliferation and Migration in an AMP-Activated Protein Kinase-Independent FashionQ35122850
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesisQ35153802
Beneficial effects of metformin on haemostasis and vascular function in man.Q35539943
Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.Q35540959
Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.Q35629996
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Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cellsQ35884622
Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cellsQ36419610
Platelets increase the proliferation of ovarian cancer cellsQ36462411
Metformin intake is associated with better survival in ovarian cancer: a case-control studyQ36557010
Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in RatQ36821921
FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawalQ36867341
Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.Q37205539
Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer CellsQ37280136
Metformin therapy associated with survival benefit in lung cancer patients with diabetesQ37376577
Metformin: taking away the candy for cancer?Q37775372
The platelet contribution to cancer progressionQ37805788
The role of blood platelets in tumor angiogenesisQ37822079
Mechanisms of platelet activation by thrombin: A short historyQ37964279
Metformin, cancer and glucose metabolismQ38255936
Effects of oral hypoglycemic agents on platelet functionQ38508849
Platelets in cancer metastasis: To help the "villain" to do evilQ38584175
Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitroQ38854319
Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 statusQ38942314
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cellsQ39219080
Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.Q39639032
Enhanced chemoresistance and tumor sphere formation as a laboratory model for peritoneal micrometastasis in epithelial ovarian cancer.Q39701137
A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell lineQ39774191
Metformin Synergistically Enhances Cisplatin-Induced Cytotoxicity in Esophageal Squamous Cancer Cells under Glucose-Deprivation ConditionsQ41963534
Metformin inhibits inflammatory angiogenesis in a murine sponge modelQ43201275
The effect of metformin on mean platelet volume in dıabetıc patientsQ43982348
The direct effects of metformin on platelet function in vitroQ46584886
Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway.Q51851159
Metformin action: concentrations matterQ52970022
Prostaglandins and platelet aggregation.Q54541982
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.Q54599219
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
ovarian cancerQ172341
P304page(s)20865-20880
P577publication date2017-02-15
P1433published inOncotargetQ1573155
P1476titleDiabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
P478volume8

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cites work (P2860)
Q92421604Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
Q57478732Diphlorethohydroxycarmalol Isolated from Represses High Glucose-Induced Angiogenesis In Vitro and In Vivo
Q92618041Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal metastasis
Q41080847Marketed drugs used for the management of hypercholesterolemia as anticancer armament
Q64105328Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
Q47265780The impact on high-grade serous ovarian cancer of obesity and lipid metabolism-related gene expression patterns: the underestimated driving force affecting prognosis

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