| scholarly article | Q13442814 |
| P356 | DOI | 10.1593/NEO.11148 |
| P8608 | Fatcat ID | release_eaqxeikcsfelhikkpvl32o7yka |
| P932 | PMC publication ID | 3084625 |
| P698 | PubMed publication ID | 21532889 |
| P5875 | ResearchGate publication ID | 51089083 |
| P50 | author | Rondell P Graham | Q48088845 |
| P2093 | author name string | Shailendra Giri | |
| Viji Shridhar | |||
| Ramandeep Rattan | |||
| Jacie L Maguire | |||
| P2860 | cites work | Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug? | Q22241958 |
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| Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy | Q33926391 | ||
| Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated [...] | Q34113009 | ||
| Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice | Q34560435 | ||
| Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission | Q34611836 | ||
| Current management strategies for ovarian cancer | Q34634661 | ||
| Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model | Q37023195 | ||
| Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner | Q37293802 | ||
| AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells | Q39733339 | ||
| In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. | Q39979957 | ||
| The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. | Q40021818 | ||
| Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. | Q40473451 | ||
| Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer | Q40488126 | ||
| Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase | Q43130305 | ||
| Metformin inhibits inflammatory angiogenesis in a murine sponge model | Q43201275 | ||
| Prevention of pancreatic cancer induction in hamsters by metformin | Q43552285 | ||
| Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1. | Q46025973 | ||
| Metformin suppresses intestinal polyp growth in ApcMin/+ mice | Q46357678 | ||
| AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress | Q47858200 | ||
| P433 | issue | 5 | |
| P921 | main subject | metformin | Q19484 |
| ovarian cancer | Q172341 | ||
| cytotoxicity | Q246181 | ||
| cisplatin | Q412415 | ||
| P304 | page(s) | 483-491 | |
| P577 | publication date | 2011-05-01 | |
| P1433 | published in | Neoplasia | Q2962042 |
| P1476 | title | Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo | |
| P478 | volume | 13 |
| Q30252410 | A SEER-Medicare analysis of the impact of metformin on overall survival in ovarian cancer |
| Q36413261 | A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models |
| Q38452411 | A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells |
| Q38924813 | AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-κB pathway |
| Q104500142 | Adaptation of metabolism to multicellular aggregation, hypoxia and obese stromal cell incorporation as potential measure of survival of ovarian metastases |
| Q39270001 | Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. |
| Q36821921 | Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat |
| Q35580483 | Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular endothelial growth factor receptor Flk-1. |
| Q55465526 | Antitumor mechanism of metformin via adenosine monophosphate-activated protein kinase (AMPK) activation |
| Q43765815 | Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma |
| Q90470049 | Association of metformin intake with bladder cancer risk and oncologic outcomes in type 2 diabetes mellitus patients: A systematic review and meta-analysis |
| Q35321462 | Attenuating tumour angiogenesis: a preventive role of metformin against breast cancer |
| Q38428730 | Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis |
| Q38147841 | Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates |
| Q92167818 | Biguanides in combination with olaparib limits tumorigenesis of drug-resistant ovarian cancer cells through inhibition of Snail |
| Q41458947 | Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells |
| Q37448116 | Cancer subclonal genetic architecture as a key to personalized medicine |
| Q35769619 | Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy |
| Q35871269 | Clinical benefits of metformin in gynecologic oncology |
| Q38818730 | Combinational strategies of metformin and chemotherapy in cancers |
| Q45072344 | Current Gaps in Ovarian Cancer Epidemiology: The Need for New Population-Based Research. |
| Q38901228 | Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death |
| Q33591379 | Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression |
| Q34227594 | Dietary energy balance modulates ovarian cancer progression and metastasis |
| Q38001521 | Does use of metformin protect against cancer in Type 2 diabetes mellitus? |
| Q55259169 | Dose-Dependent Relationship Between Metformin and Colorectal Cancer Occurrence Among Patients with Type 2 Diabetes-A Nationwide Cohort Study. |
| Q36215473 | Early treatment with metformin induces resistance against tumor growth in adult rats |
| Q86086448 | Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation |
| Q35761271 | Effect of metformin on apoptosis induction in ovarian cancer cells. |
| Q37326781 | Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line |
| Q38825815 | Effect of metformin on the human T98G glioblastoma multiforme cell line |
| Q35053962 | Effects of metformin on CD133+ colorectal cancer cells in diabetic patients |
| Q132042456 | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| Q34135466 | Epigenetic targeting of ovarian cancer stem cells |
| Q38914047 | Evaluation of antagonistic effects of metformin with Cisplatin in gastric cancer cells |
| Q36249363 | Evaluation of the cytotoxicity of the Bithionol - cisplatin combination in a panel of human ovarian cancer cell lines. |
| Q35958147 | Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer |
| Q33850034 | Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer |
| Q61799673 | High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone |
| Q36414231 | Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer |
| Q34476559 | In vitro and in vivoanti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma |
| Q35375383 | Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells |
| Q49194546 | Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice |
| Q88069686 | Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis |
| Q38721748 | Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model. |
| Q47128274 | Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells |
| Q36419610 | Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cells |
| Q28072521 | Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk |
| Q35149589 | Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy |
| Q38778339 | Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study |
| Q91199171 | MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis |
| Q61817998 | Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells |
| Q35702142 | Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo |
| Q28550674 | Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients |
| Q98772063 | Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU |
| Q36774352 | Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction |
| Q27348974 | Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages |
| Q33890763 | Metformin against cancer stem cells through the modulation of energy metabolism: special considerations on ovarian cancer |
| Q46418627 | Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts |
| Q64375136 | Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway |
| Q58699189 | Metformin and blood cancers |
| Q50105959 | Metformin and cancer: An existing drug for cancer prevention and therapy |
| Q52925310 | Metformin and epithelial ovarian cancer therapeutics |
| Q50001260 | Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. |
| Q61813755 | Metformin attenuates hypoxia-induced resistance to cisplatin in the HepG2 cell line |
| Q34426894 | Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin‑resistant ovarian cancer |
| Q37365589 | Metformin decreases the incidence of ovarian hyperstimulation syndrome: an experimental study. |
| Q47985167 | Metformin enhances doxorubicin sensitivity via inhibition of doxorubicin efflux in P-gp-overexpressing MCF-7 cells. |
| Q40979804 | Metformin enhances the cytotoxicity of 5-aminolevulinic acid-mediated photodynamic therapy in vitro |
| Q35827623 | Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer |
| Q49566239 | Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2. |
| Q41345865 | Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells |
| Q33610569 | Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones). |
| Q39350733 | Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway |
| Q36896122 | Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK |
| Q35287351 | Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. |
| Q58733981 | Metformin inhibits ovarian cancer growth and migration in vitro and in vivo by enhancing cisplatin cytotoxicity |
| Q52331264 | Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation |
| Q36516580 | Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis |
| Q49745178 | Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway |
| Q36557010 | Metformin intake is associated with better survival in ovarian cancer: a case-control study |
| Q54508172 | Metformin interacts with AMPK through binding to γ subunit |
| Q39312255 | Metformin is synthetically lethal with glucose withdrawal in cancer cells. |
| Q35884622 | Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells |
| Q34104019 | Metformin limits the adipocyte tumor-promoting effect on ovarian cancer. |
| Q91598281 | Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells |
| Q39480588 | Metformin mediated reversal of epithelial to mesenchymal transition is triggered by epigenetic changes in E-cadherin promoter |
| Q35828675 | Metformin potentiates rapamycin and cisplatin in gastric cancer in mice |
| Q35793665 | Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction |
| Q28478148 | Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression |
| Q58573280 | Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene |
| Q36632485 | Metformin targets ovarian cancer stem cells in vitro and in vivo |
| Q53252632 | Metformin's performance in in vitro and in vivo genetic toxicology studies |
| Q37280136 | Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells |
| Q39228631 | Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel |
| Q35764409 | Metformin: Multi-faceted protection against cancer |
| Q30833290 | Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity |
| Q92542993 | Mitochondrial Involvement in Migration, Invasion and Metastasis |
| Q42265576 | Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer |
| Q90719910 | Multivariable analysis of association of beta-blocker use and survival in advanced ovarian cancer |
| Q27318677 | Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer |
| Q37733377 | New insight for metformin against bladder cancer |
| Q39272833 | New insights into antidiabetic drugs: Possible applications in cancer treatment. |
| Q38187997 | New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells |
| Q35669726 | Noninvasive Imaging Reveals Inhibition of Ovarian Cancer by Targeting CXCL12-CXCR4 |
| Q92920996 | Novel Metformin-Based Schiff Bases: Synthesis, Characterization, and Antibacterial Evaluation |
| Q27010558 | Old drug, new trick: repurposing metformin for gynecologic cancers? |
| Q41879186 | Overcoming Intratumor Heterogeneity of Polygenic Cancer Drug Resistance with Improved Biomarker Integration |
| Q37978771 | Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches. |
| Q37731504 | Paradoxic effects of metformin on endothelial cells and angiogenesis |
| Q90133996 | Phase I study of metformin in combination with carboplatin/paclitaxel chemotherapy in patients with advanced epithelial ovarian cancer |
| Q47098834 | Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer |
| Q33655236 | Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review |
| Q38765414 | Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer. |
| Q33699826 | Preclinical therapeutic potential of a nitrosylating agent in the treatment of ovarian cancer |
| Q64101951 | Prognosis and risk factors of patients with upper urinary tract urothelial carcinoma and postoperative recurrence of bladder cancer in central China |
| Q90588103 | Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: a retrospective cohort study |
| Q35057783 | Protective effect of metformin against cisplatin-induced ototoxicity in an auditory cell line. |
| Q38702241 | Quinacrine in endometrial cancer: Repurposing an old antimalarial drug |
| Q26853096 | Regulation of Ovarian Cancer Stem Cells or Tumor-Initiating Cells |
| Q39460513 | Relevance of the OCT1 transporter to the antineoplastic effect of biguanides |
| Q33942068 | Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation |
| Q38637111 | Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly. |
| Q33817206 | Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation |
| Q36665179 | Role of the Microenvironment in Ovarian Cancer Stem Cell Maintenance |
| Q44670997 | Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach |
| Q37352296 | Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations |
| Q36689047 | Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis |
| Q36109004 | Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines |
| Q38702245 | Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer. |
| Q53218614 | Targeting AMPK in the treatment of malignancies |
| Q60916970 | Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer |
| Q38016107 | Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects |
| Q38783105 | Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence |
| Q36820568 | The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer |
| Q35669733 | The Interconnectedness of Cancer Cell Signaling |
| Q57821563 | The antiangiogenic action of cisplatin on endothelial cells is mediated through the release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells |
| Q39042097 | The antidiabetic drug metformin inhibits the proliferation of bladder cancer cells in vitro and in vivo |
| Q38728567 | The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development |
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