Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach

scientific article

Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPUBH.2017.00277
P932PMC publication ID5650619
P698PubMed publication ID29085821

P2093author name stringAhmed M Malki
Lobna Al-Zaidan
Rasha Abu El Ruz
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
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AIF: not just an apoptosis-inducing factorQ28257046
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Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenograftsQ36050677
AMPK and p53 help cells through lean times.Q36212558
Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surfaceQ36356313
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Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitroQ36824580
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Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategyQ37463664
Glucose promotes breast cancer aggression and reduces metformin efficacy.Q37525828
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.Q37543714
Aberrant DNA Double-strand Break Repair Threads in Breast Carcinoma: Orchestrating Genomic Insult SurvivalQ37552296
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Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.Q38867428
The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: implications for cancer therapy and prevention.Q39030694
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activationQ39177084
Metformin is synthetically lethal with glucose withdrawal in cancer cells.Q39312255
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.Q39346958
Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expressionQ39357443
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.Q39370938
Metformin reduces endogenous reactive oxygen species and associated DNA damageQ39409229
The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivoQ39416862
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activityQ39909222
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.Q40021818
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.Q40143359
Recent advances in the use of metformin: can treating diabetes prevent breast cancer?Q41083568
Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetesQ42165343
Cooperation and competition in the evolution of ATP-producing pathwaysQ43562868
The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membraneQ44402671
Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signalingQ46263878
Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screeningQ46610150
The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.Q46688906
Efficient fractionation and improved protein identification by peptide OFFGEL electrophoresis.Q51161691
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Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide PrecolumnsQ57666311
Metformin increases glucose transporter protein and gene expression in human fibroblastsQ72547181
Prognostic relevance of glycosylation-associated genes in breast cancerQ87690838
Metformin use and improved response to therapy in esophageal adenocarcinomaQ95405899
P921main subjectmetforminQ19484
P304page(s)277
P577publication date2017-10-16
P1433published inFrontiers in Public HealthQ27725050
P1476titleScreening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach
P478volume5

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cites work (P2860)
Q90221652Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells
Q64934294Personalized medicine in breast cancer: pharmacogenomics approaches.
Q59138314Pleiotropic Effects of Metformin on Cancer

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