Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression

scientific article

Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1621/NRS.07009
P932PMC publication ID2807635
P698PubMed publication ID20087430
P5875ResearchGate publication ID41089513

P2093author name stringJ Dinny Graham
Christine L Clarke
Katherine M Scarpin
Patricia A Mote
P2860cites workA steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complexQ22009369
Expression of progesterone receptors A and B in the mouse ovary during the estrous cycleQ44814509
DNA instructed displacement of histones H2A and H2B at an inducible promoterQ45138457
Murine progesterone receptor exists predominantly as the 83-kilodalton 'A' formQ45215116
A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoformsQ45352912
Receptor isoforms that mediate estrogen and progestagen action in the female lower urinary tractQ46154702
Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermiaQ46331333
Progesterone receptor isoforms A and B: temporal and spatial differences in expression during murine mammary gland developmentQ46477275
Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoformsQ46490362
Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells.Q46564578
Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptorQ46686001
Biochemical characterization and subunit structure of quail oviduct progesterone receptorQ46920866
Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivoQ24296381
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamilyQ24530578
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor bindingQ24554243
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BQ24556548
Direct visualization of the human estrogen receptor alpha reveals a role for ligand in the nuclear distribution of the receptorQ24643098
Distinct steady-state nuclear receptor coregulator complexes exist in vivoQ24679780
Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancerQ24802784
Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cellsQ24802807
Sequence and characterization of a coactivator for the steroid hormone receptor superfamilyQ27860465
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
The steroid and thyroid hormone receptor superfamilyQ27861095
The function of PML in p53-dependent apoptosisQ28140732
Combinatorial control of gene expression by nuclear receptors and coregulatorsQ28209095
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23Q28218453
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activityQ28218469
The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRTQ28239712
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancerQ28245902
Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological ControlQ28315064
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland developmentQ28509946
Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetateQ28578932
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Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoformQ28586470
Nuclear receptor coregulators: cellular and molecular biologyQ29547588
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalitiesQ29615568
A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoformQ30419213
The Year in Basic Science: update of estrogen plus progestin therapy for menopausal hormone replacement implicating stem cells in the increased breast cancer riskQ30485457
Risk of breast cancer with progestins: critical assessment of current dataQ30885896
Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growthQ33266857
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single geneQ33766903
Steroid hormone receptor expression and action in boneQ33829036
Nuclear receptors: one big familyQ34015466
Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in miceQ34042802
Progesterone receptor coactivatorsQ34099992
Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.Q39927821
Focal subnuclear distribution of progesterone receptor is ligand dependent and associated with transcriptional activity.Q40223595
E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.Q40236413
Steroid receptor coactivator AIB1 in endometrial carcinoma, hyperplasia and normal endometrium: Correlation with clinicopathologic parameters and biomarkersQ40287637
Dual roles for the phosphatase PPM1D in regulating progesterone receptor functionQ40340400
Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function.Q40341667
Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology.Q40488240
Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue.Q40772612
Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cellsQ40862902
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathwaysQ40995230
Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus.Q41300114
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B functionQ41523742
Physiological action of progesterone in target tissuesQ41574892
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.Q42439064
Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.Q42833924
The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasomeQ43552379
The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptorsQ43592371
Relative expression of progesterone receptors A and B in endometrioid cancers of the endometriumQ43627814
Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cellsQ43805305
New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulationQ44000727
Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometriumQ44018218
The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepressionQ44061992
Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometriumQ44306864
Loss of coordinated androgen regulation in nonmalignant ovarian epithelial cells with BRCA1/2 mutations and ovarian cancer cellsQ44443211
Expression of estrogen receptor coregulators in normal and malignant human endometriumQ44747963
Expression of nuclear receptors and cofactors in human endometrium and myometriumQ44774099
Subnuclear distribution of progesterone receptors A and B in normal and malignant endometriumQ44787029
Breast cancer and hormone-replacement therapy in the Million Women StudyQ34223870
Progesterone receptor transcription and non-transcription signaling mechanismsQ34282690
Role of molecular chaperones in steroid receptor actionQ34332069
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) geneQ34460757
Nuclear receptor coregulators and human diseaseQ34645711
The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?Q34932849
Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouseQ35071146
The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptorsQ35671179
MCF10AT: a model for the evolution of cancer from proliferative breast diseaseQ35773830
The evolution of the nuclear receptor superfamilyQ35830301
Nuclear structure in cancer cellsQ35877173
Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signalingQ35918601
A contemporary understanding of progesterone receptor functionQ35947902
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexesQ35974510
Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonistsQ35975335
Steroid Hormones, their receptors and neuroendocrine systemQ36369603
Transcription activation by estrogen and progesterone receptorsQ36468309
Integration of progesterone receptor action with rapid signaling events in breast cancer modelsQ36580735
An overview of menopausal oestrogen-progestin hormone therapy and breast cancer riskQ36615906
Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.Q36625563
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cellsQ36672641
Challenges to defining a role for progesterone in breast cancerQ36786766
Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimeraQ36800432
Nuclear receptor coregulators: judges, juries, and executioners of cellular regulationQ36931106
Coactivators and nuclear receptor transactivationQ37130385
E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptorsQ37146105
Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptorsQ37216588
Progestin receptors: isoforms and antihormone actionQ37544485
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.Q38308917
Progesterone receptor isoforms A and B differentially regulate MUC1 expression in uterine epithelial cells.Q38312696
5'-Heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated "C"-receptor and unique A-receptor messagesQ38338114
Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesisQ38456582
Gene regulation by steroid hormonesQ39166614
Decreased expression of e6-associated protein in breast and prostate carcinomasQ46964083
Developmental regulation of murine mammary progesterone receptor gene expression.Q52241264
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.Q52571111
Signalling through nuclear receptors.Q53419452
Overlapping and Distinct Expression of Progesterone Receptors A and B in Mouse Uterus and Mammary Gland during the Estrous CycleQ57287325
In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivityQ57287565
Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumoursQ58433771
Colocalization of Progesterone Receptors A and B by Dual Immunofluorescent Histochemistry in Human Endometrium during the Menstrual Cycle1Q60662131
Purification of unactivated progesterone receptor and identification of novel receptor-associated proteinsQ68708793
Evidence for a single steroid-binding protein in the rabbit progesterone receptorQ68921807
Two progesterone receptors in the oviduct of the freshwater turtle Chrysemys picta: possible homology to mammalian and avian progesterone receptor systemsQ69704840
Rat uterine progesterone receptor analyzed by [3H]R5020 photoaffinity labeling: evidence that the A and B subunits are not equimolarQ70169912
Progesterone-binding components of chick oviduct. IV. Characterization of purified subunitsQ70349260
Progesterone-binding protein of chick oviduct. VI. Interaction of purified progesterone-receptor components with nuclear constituentsQ70357116
An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activityQ71788031
Characterization of progesterone receptor A and B expression in human breast cancerQ71804872
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptorsQ72281048
The ontogeny of gene expression of progestin receptors in the female rat brainQ72689920
Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancerQ73483264
The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domainQ73509901
An N-terminally truncated third progesterone receptor protein, PR(C), forms heterodimers with PR(B) but interferes in PR(B)-DNA bindingQ73962652
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoformQ74281193
Expression of a subset of steroid receptor cofactors is associated with progesterone receptor expression in meningiomasQ74352306
Endometrial nuclear receptor co-factors SRC-1 and N-CoR are increased in human endometrium during menstruationQ74373258
Definition of a negative modulation domain in the human progesterone receptorQ77221132
Differential hormonal regulation and function of progesterone receptor isoforms in normal adult mouse mammary glandQ79818790
Progesterone receptor isoforms and proliferation in the rat mammary gland during developmentQ79855496
The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expressionQ80447161
Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptorQ81225674
Progesterone receptor isoforms in normal and malignant breastQ81424333
Estrogens, progestins, and risk of breast cancerQ81424340
Progesterone signaling in mammary gland developmentQ81430432
Turtle oviduct progesterone receptor: radioligand and immunocytochemical studies of changes during the seasonal cycleQ82863407
Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-BQ83954270
P407language of work or nameEnglishQ1860
P921main subjectintracellular receptorQ117980
polycyclic compoundQ426145
cellQ7868
hormoneQ11364
nucleusQ40260
progesterone receptorQ24783718
P304page(s)e009
P577publication date2009-12-31
P1433published inNuclear Receptor SignalingQ15766610
P1476titleProgesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression
P478volume7

Reverse relations

cites work (P2860)
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