Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model

scientific article

Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/FPC.0000000000000044
P8608Fatcat IDrelease_2b22q7w2frhspph3h6z6rfvhrq
P932PMC publication ID4019208
P698PubMed publication ID24710003

P50authorLaura B RamseyQ42187542
Mary V RellingQ88331217
P2093author name stringWilliam E Evans
Cheng Cheng
Charles J Sherr
Richard T Williams
Laura J Janke
Mathew J Edick
P2860cites workChemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemiaQ24622397
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosingQ24632749
Treating childhood acute lymphoblastic leukemia without cranial irradiationQ24644599
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrationsQ27820693
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemiaQ28943431
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
Dose translation from animal to human studies revisitedQ29618049
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprineQ33336860
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemiaQ33624061
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locusQ33882066
Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphismQ34429411
Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemiaQ34546468
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprineQ34755513
Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology groupQ34992080
Germline genetic variation and treatment response on CCG-1891.Q35190653
Substrain-specific differences in survival and osteonecrosis incidence in a mouse modelQ36481285
The ARF tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemiaQ36908947
The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemiasQ37333312
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 studyQ37502607
A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holidayQ41821365
Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemiaQ42381521
A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group).Q42630783
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.Q42826829
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemiaQ43221788
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphomaQ43231309
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphismQ44097585
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemiaQ44917795
Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.Q45964819
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemiaQ46398603
Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypesQ46616526
Thiopurine methyltransferase in acute lymphoblastic leukemiaQ46886254
High incidence of secondary brain tumours after radiotherapy and antimetabolites.Q48163138
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.Q52579212
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemiaQ68092294
Long-term culture of murine bone marrow precursors of B lymphocytesQ68836279
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiencyQ74337520
P433issue5
P921main subjectmercaptopurineQ418529
murine modelQ122890741
P304page(s)263-271
P577publication date2014-05-01
P1433published inPharmacogenetics and GenomicsQ10534561
P1476titleHost thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model
P478volume24

Reverse relations

cites work (P2860)
Q35740019Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia
Q33774499Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
Q49387116Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values.
Q90911260Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice