Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice

scientific article published on 24 October 2019

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41375-019-0583-9
P698PubMed publication ID31645647

P50authorYoichi KakutaQ56493369
Masahiro KawaharaQ66829145
Goichi TatsumiQ90911256
P2093author name stringAkira Andoh
Atsushi Nishida
Osamu Inatomi
Takayuki Imai
Akihiko Yokoyama
Katsuyuki Kito
Ai Nishishita-Asai
P2860cites workDiplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasmsQ57518085
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter studyQ60609850
Thiopurine methyltransferase activity in American white subjects and black subjectsQ72752612
Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detectionQ73073741
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel diseaseQ86757273
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurineQ91688847
Genome engineering using the CRISPR-Cas9 systemQ22122027
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-ThioguanineQ27727699
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.Q27852067
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicityQ28115755
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammationQ28742707
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprineQ33336860
Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine modelQ33603164
The purine path to chemotherapyQ34045219
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopeniaQ34433052
Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemiaQ34459885
The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year reviewQ34559065
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancerQ34728470
Clinical implementation of pharmacogenomics: overcoming genetic exceptionalismQ36248267
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 studyQ37502607
Toxicity and response to thiopurines in patients with inflammatory bowel diseaseQ38443981
Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cellsQ39310070
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Q40252270
Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variationQ41506244
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.Q41667877
A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holidayQ41821365
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemiaQ41901150
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemiaQ41911065
Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemiaQ42260284
Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cellsQ42285099
Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trialQ43020434
Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotideQ43202350
Thiopurine methyltransferase activity in the Jewish population of IsraelQ43616920
Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese populationQ44913924
Outcome with the hyper-CVAD regimens in lymphoblastic lymphomaQ44922356
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairQ46210604
Analysis of variation in mouse TPMT genotype, expression and activityQ47768316
Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy.Q51735726
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.Q52579212
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.Q52721121
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children.Q54495132
Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.Q54513762
P433issue3
P304page(s)882-894
P577publication date2019-10-24
P1433published inLeukemiaQ6534498
P1476titleThiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice
P478volume34

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