scholarly article | Q13442814 |
P356 | DOI | 10.1038/S41375-019-0583-9 |
P698 | PubMed publication ID | 31645647 |
P50 | author | Yoichi Kakuta | Q56493369 |
Masahiro Kawahara | Q66829145 | ||
Goichi Tatsumi | Q90911256 | ||
P2093 | author name string | Akira Andoh | |
Atsushi Nishida | |||
Osamu Inatomi | |||
Takayuki Imai | |||
Akihiko Yokoyama | |||
Katsuyuki Kito | |||
Ai Nishishita-Asai | |||
P2860 | cites work | Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms | Q57518085 |
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study | Q60609850 | ||
Thiopurine methyltransferase activity in American white subjects and black subjects | Q72752612 | ||
Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detection | Q73073741 | ||
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease | Q86757273 | ||
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine | Q91688847 | ||
Genome engineering using the CRISPR-Cas9 system | Q22122027 | ||
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine | Q27727699 | ||
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. | Q27852067 | ||
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity | Q28115755 | ||
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation | Q28742707 | ||
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine | Q33336860 | ||
Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model | Q33603164 | ||
The purine path to chemotherapy | Q34045219 | ||
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia | Q34433052 | ||
Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia | Q34459885 | ||
The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review | Q34559065 | ||
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer | Q34728470 | ||
Clinical implementation of pharmacogenomics: overcoming genetic exceptionalism | Q36248267 | ||
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study | Q37502607 | ||
Toxicity and response to thiopurines in patients with inflammatory bowel disease | Q38443981 | ||
Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells | Q39310070 | ||
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. | Q40252270 | ||
Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variation | Q41506244 | ||
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD. | Q41667877 | ||
A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday | Q41821365 | ||
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia | Q41901150 | ||
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia | Q41911065 | ||
Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia | Q42260284 | ||
Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells | Q42285099 | ||
Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial | Q43020434 | ||
Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide | Q43202350 | ||
Thiopurine methyltransferase activity in the Jewish population of Israel | Q43616920 | ||
Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese population | Q44913924 | ||
Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma | Q44922356 | ||
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair | Q46210604 | ||
Analysis of variation in mouse TPMT genotype, expression and activity | Q47768316 | ||
Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy. | Q51735726 | ||
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. | Q52579212 | ||
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment. | Q52721121 | ||
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. | Q54495132 | ||
Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease. | Q54513762 | ||
P433 | issue | 3 | |
P304 | page(s) | 882-894 | |
P577 | publication date | 2019-10-24 | |
P1433 | published in | Leukemia | Q6534498 |
P1476 | title | Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice | |
P478 | volume | 34 |
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