Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice

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Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.114.214197
P932PMC publication ID4019316
P698PubMed publication ID24700885
P5875ResearchGate publication ID261375012

P50authorWendy KeungQ51434667
Deborah M MuoioQ56285554
John R UssherQ91702545
P2093author name stringOlga R Ilkayeva
Liyan Zhang
Natasha Fillmore
Timothy R Koves
Jun Mori
Gary D Lopaschuk
Cory S Wagg
David G Lopaschuk
Jagdip S Jaswal
P2860cites workProlonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in ratsQ43516811
Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humansQ44200139
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolaseQ44517385
Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.Q45922672
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetesQ46626385
Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatmentQ46814911
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.Q48588727
Effect of pressure development on oxygen consumption by isolated rat heartQ72218889
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signalingQ79400004
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injuryQ83713235
Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistanceQ85208761
2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart AssociatQ86690927
Trimetazidine for stable anginaQ24245946
Pyridine nucleotide regulation of cardiac intermediary metabolismQ26822692
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistanceQ28253498
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolaseQ28373346
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidationQ28578053
Cellular mechanisms of insulin resistanceQ29619549
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.Q33251776
Skeletal muscle metabolism is a major determinant of resting energy expenditureQ34262816
Disordered lipid metabolism and the pathogenesis of insulin resistanceQ34370965
A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failureQ34562883
Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathyQ34819581
Mitochondrial dysfunction in patients with primary congenital insulin resistanceQ35015797
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.Q35063267
Lipid-induced mitochondrial stress and insulin action in muscleQ35947486
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivityQ36082167
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivityQ36122773
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceQ37105295
The malonyl CoA axis as a potential target for treating ischaemic heart diseaseQ37171491
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic controlQ37371666
Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.Q37831555
A ceramide-centric view of insulin resistanceQ38007631
Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) miceQ39783085
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistanceQ40028148
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumptionQ41119321
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humansQ42247172
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.Q43240756
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
preproinsulinQ7240673
insulin resistanceQ1053470
P304page(s)487-496
P577publication date2014-04-03
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleTreatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice
P478volume349