review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Hirvonen A | |
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Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases | Q50336069 | ||
Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis | Q23922919 | ||
Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene | Q24300296 | ||
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The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics | Q24545508 | ||
Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1 | Q24563504 | ||
Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion | Q24648022 | ||
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Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression | Q28116125 | ||
Functional significance of different human CYP1A1 genotypes | Q28243236 | ||
The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression | Q28250605 | ||
Immunohistochemical localization of glutathione S-transferases in human lung | Q28256397 | ||
Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5'-diphosphate glucuronosyltransferases. | Q50698081 | ||
N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk. | Q50867318 | ||
The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction. | Q50868529 | ||
Identification and prevalence study of 17 allelic variants of the human NAT2 gene in a white population. | Q50987813 | ||
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. | Q50995791 | ||
Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. | Q50998730 | ||
Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer. | Q51017197 | ||
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity. | Q51593328 | ||
The molecular basis of the human serum paraoxonase activity polymorphism. | Q52542904 | ||
Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. | Q52980548 | ||
Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. | Q53003796 | ||
Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. | Q53016262 | ||
Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. | Q53432399 | ||
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among Northwestern Mediterraneans. | Q53441209 | ||
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. | Q53442109 | ||
Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas. | Q53450855 | ||
Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. | Q53453852 | ||
The effect of tobacco on lung cancer risk depends on CYP2D6 activity. | Q53457160 | ||
N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine. | Q53462857 | ||
Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. | Q53466370 | ||
Human liver glucuronidation of benzidine. | Q53470176 | ||
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. | Q53470242 | ||
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population. | Q53484906 | ||
Stereoselective metabolism of (—)-benzo [a]pyrene-7,8-diol by human lung microsomes and peripheral blood lymphocytes: effect of smoking | Q53489701 | ||
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. | Q53490047 | ||
DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family. | Q53497663 | ||
Activation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to diolepoxides by human polymorphonuclear leukocytes or myeloperoxidase. | Q53500144 | ||
Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar. | Q53794450 | ||
Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes. | Q54170839 | ||
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. | Q54216734 | ||
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility | Q57240094 | ||
The apparent ubiquity of epoxide hydratase in rat organs | Q57552349 | ||
Larynx cancer risk in relation to glutathione S-transferase M1 and T1 genotypes and tobacco smoking | Q57665404 | ||
A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer | Q57982063 | ||
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles | Q58003139 | ||
Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males | Q58047512 | ||
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide | Q59062693 | ||
Life (and death) in a malignant tumour | Q59098941 | ||
SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers | Q59904479 | ||
Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population | Q62492303 | ||
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease. | Q64929649 | ||
Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung | Q66595463 | ||
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 | Q67260608 | ||
Human cytochrome P450IIE1 gene: DraI polymorphism and susceptibility to cancer | Q67526402 | ||
Molecular genotyping of N-acetylation polymorphism to predict phenotype | Q67577116 | ||
Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes | Q67652737 | ||
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression | Q28258522 | ||
Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification | Q28263684 | ||
The CYP2 A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis | Q28290813 | ||
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity | Q28293841 | ||
The molecular biology of the flavin-containing monooxygenases of man | Q28300051 | ||
Nomenclature for N-acetyltransferases | Q28302652 | ||
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects | Q28322217 | ||
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon | Q28609945 | ||
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine | Q28609999 | ||
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance | Q29616511 | ||
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502). | Q32049036 | ||
Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1 | Q33269439 | ||
Rotation and interaction with epoxide hydrase of cytochrome P-450 in proteoliposomes | Q33404015 | ||
The association of the slow acetylator phenotype with bladder cancer | Q33670806 | ||
Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds | Q34213703 | ||
The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization | Q34317222 | ||
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. | Q34330493 | ||
The multistep nature of cancer | Q34366937 | ||
Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians | Q34434115 | ||
Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1 | Q34677484 | ||
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E). | Q34729809 | ||
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema | Q34742826 | ||
Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism | Q34843733 | ||
Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis | Q34844333 | ||
Pharmacogenetics: the slow, the rapid, and the ultrarapid | Q35085298 | ||
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences | Q35238375 | ||
Multistep carcinogenesis: a 1992 perspective | Q35425075 | ||
Acetyltransferases and susceptibility to chemicals | Q35623492 | ||
Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity | Q35643631 | ||
The role of glutathione and glutathione transferases in chemical carcinogenesis | Q37913204 | ||
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. | Q38304359 | ||
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects | Q38317576 | ||
Identification of a novel allele at the human NAT1 acetyltransferase locus | Q38346650 | ||
The genetic toxicology of putative nongenotoxic carcinogens | Q38573715 | ||
Dietary Factors and Risk of Colon Cancer | Q39024408 | ||
Gene Structure at the Human UGT1 Locus Creates Diversity in Isozyme Structure, Substrate Specificity, and Regulation | Q40473981 | ||
Two common RFLPs of the human CYP2E gene | Q40504119 | ||
Mspl polymorphism of the human CYP2E gene | Q40508074 | ||
Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology. | Q40530680 | ||
Ah receptor: a novel ligand-activated transcription factor | Q40573515 | ||
Model for the epigenetic mechanism of action of nongenotoxic carcinogens | Q40606096 | ||
Carcinogen activation by sulfate conjugate formation | Q40693468 | ||
The CYP1A1 gene and cancer susceptibility | Q40712753 | ||
The AH-receptor: genetics, structure and function | Q40803701 | ||
Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity | Q40808649 | ||
Pharmacogenetics: its biologic roots and the medical challenge | Q40848184 | ||
Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. | Q40857024 | ||
Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis | Q40870794 | ||
Mechanisms for species differences in receptor-mediated carcinogenesis | Q40933331 | ||
Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. | Q40946792 | ||
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer | Q40992263 | ||
Metabolic polymorphisms and cancer susceptibility. | Q41041185 | ||
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking. | Q41315418 | ||
Polymorphic drug metabolism: studies with recombinant Chinese hamster cells and analyses in human populations | Q41401677 | ||
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | Q41457556 | ||
Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line | Q41458896 | ||
The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases | Q41510610 | ||
Combinations of susceptible genotypes and individual responses to toxicants | Q41561476 | ||
Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers | Q41583435 | ||
N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells | Q41618193 | ||
Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder | Q41671848 | ||
Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A. | Q41849983 | ||
Myeloperoxidase in human lung lavage. I. A marker of local neutrophil activity | Q41898926 | ||
Multiple N-acetyltransferases and drug metabolism. Tissue distribution, characterization and significance of mammalian N-acetyltransferase | Q41908976 | ||
The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. | Q42452435 | ||
NAD(P)H:quinone oxidoreductase1 (DT-diaphorase): expression, regulation, and role in cancer. | Q42480789 | ||
Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans | Q42490446 | ||
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma | Q42516808 | ||
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. | Q42694246 | ||
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism | Q42834608 | ||
Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer | Q43904565 | ||
Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population | Q44115646 | ||
A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. men. | Q45082452 | ||
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California. | Q46049355 | ||
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations | Q46141212 | ||
Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene | Q46569661 | ||
Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County | Q46620718 | ||
A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. | Q47704400 | ||
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease. | Q47773962 | ||
Nicotine metabolism defect reduces smoking | Q47877657 | ||
Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa. | Q48017311 | ||
Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins | Q48051232 | ||
Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region | Q48080704 | ||
Nomenclature for human CYP2D6 alleles | Q48785867 | ||
Human CYP1A1 (cytochrome P1450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population | Q67715931 | ||
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population | Q67809023 | ||
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers | Q67837226 | ||
Dissociation of a new glutathione S-transferase activity in human erythrocytes | Q68109837 | ||
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes | Q68199764 | ||
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine | Q68204605 | ||
Myeloperoxidase in human lung lavage. II. Internalization of myeloperoxidase by alveolar macrophages | Q68470987 | ||
DT-diaphorase: purification, properties, and function | Q68592259 | ||
Activation of promutagens by human cDNA-expressed cytochrome P450s | Q68899927 | ||
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus | Q70583957 | ||
Lung cancer and mutations at the polymorphic NAT2 gene locus | Q70803405 | ||
Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk | Q70863843 | ||
Human N-acetylation of benzidine: role of NAT1 and NAT2 | Q71381876 | ||
Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone | Q71612339 | ||
Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk | Q71748553 | ||
Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany | Q71788233 | ||
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans | Q71794121 | ||
Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue | Q71804979 | ||
Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer | Q71835266 | ||
Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma | Q71862667 | ||
Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders | Q71878642 | ||
Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure | Q71887283 | ||
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis | Q71895813 | ||
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes | Q71899977 | ||
Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer | Q71939367 | ||
Detection of a Point Mutation in NQ01 (DT-diaphorase) in a Patient With Colon Cancer | Q71943987 | ||
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9 | Q71996232 | ||
Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population | Q72113258 | ||
Relationship between in vivo acetylator phenotypes and cytosolic N-acetyltransferase and O-acetyltransferase activities in human uroepithelial cells | Q72268447 | ||
Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe | Q72293614 | ||
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms | Q72313196 | ||
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure | Q72691106 | ||
Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activity | Q72703173 | ||
Polymorphic arylamine N-acetyltransferase (NAT2) genes in children with insulin-dependent diabetes mellitus | Q72893989 | ||
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility | Q73154991 | ||
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer | Q73248663 | ||
Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo( | Q73450157 | ||
Human acetyltransferase polymorphisms | Q73457777 | ||
Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies | Q73553696 | ||
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan | Q73635116 | ||
A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles | Q73876084 | ||
Myeloperoxidase genetic polymorphism and lung cancer risk | Q73883807 | ||
Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study | Q74251138 | ||
Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients | Q74340204 | ||
Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms | Q74390398 | ||
P921 | main subject | cancer | Q12078 |
genetic variation | Q349856 | ||
neoplasm | Q1216998 | ||
pharmaceutical preparation | Q66089252 | ||
P1104 | number of pages | 11 | |
P304 | page(s) | 37-47 | |
P577 | publication date | 1999-02-01 | |
P1433 | published in | Environmental Health Perspectives | Q1345904 |
P1476 | title | Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer | |
P478 | volume | 107 Suppl 1 |
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