| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1998PNAS...9515763P |
| P356 | DOI | 10.1073/PNAS.95.26.15763 |
| P932 | PMC publication ID | 28118 |
| P698 | PubMed publication ID | 9861044 |
| P5875 | ResearchGate publication ID | 13426859 |
| P50 | author | Don W. Cleveland | Q24004784 |
| P2093 | author name string | R H Brown | |
| D R Borchelt | |||
| P Pasinelli | |||
| M K Houseweart | |||
| P2860 | cites work | Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1 | Q22299419 |
| Structure and mechanism of interleukin-1 beta converting enzyme | Q27730830 | ||
| Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q28131805 | ||
| A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes | Q28237565 | ||
| Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis | Q28292299 | ||
| Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury | Q28511628 | ||
| Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation | Q29547561 | ||
| Superoxide dismutase: improved assays and an assay applicable to acrylamide gels | Q29615319 | ||
| Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein | Q30425734 | ||
| Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme | Q34384433 | ||
| Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells | Q34529852 | ||
| Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis | Q34718757 | ||
| Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons | Q35218435 | ||
| Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells | Q35571910 | ||
| Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity | Q35693516 | ||
| A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide | Q37550536 | ||
| A radical hypothesis for neurodegeneration | Q40385988 | ||
| Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice | Q40612435 | ||
| Programmed cell death and Bcl-2 protection in the absence of a nucleus | Q40791590 | ||
| Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis | Q41237348 | ||
| Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. | Q41368778 | ||
| Hydrogen peroxide mediates amyloid beta protein toxicity | Q41460857 | ||
| Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. | Q42981625 | ||
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. | Q46135324 | ||
| Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons | Q47991847 | ||
| Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions | Q48056432 | ||
| Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. | Q48539215 | ||
| Neuronal cell death. | Q52188024 | ||
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria | Q54965159 | ||
| Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS | Q57042894 | ||
| ALS, SOD and peroxynitrite | Q59070047 | ||
| Inhibition of ICE slows ALS in mice | Q59081638 | ||
| Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection | Q64382269 | ||
| Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo | Q72196565 | ||
| Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death | Q72549763 | ||
| Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis | Q72621641 | ||
| Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis | Q73520806 | ||
| P433 | issue | 26 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | copper | Q753 |
| amyotrophic lateral sclerosis | Q206901 | ||
| P304 | page(s) | 15763-15768 | |
| P577 | publication date | 1998-12-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase | |
| P478 | volume | 95 |
| Q30627872 | A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions |
| Q35591686 | A decade of caspases |
| Q36861919 | A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. |
| Q43954485 | ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. |
| Q33954016 | ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration |
| Q33980322 | ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. |
| Q38947838 | ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. |
| Q40409233 | Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis. |
| Q34483063 | Acetaminophen induces human neuroblastoma cell death through NFKB activation |
| Q59219368 | Amyotrophic lateral sclerosis |
| Q34175381 | Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded |
| Q34066549 | Amyotrophic lateral sclerosis: a proposed mechanism |
| Q33850692 | Animal models of neuroimmune interactions in inflammatory diseases |
| Q34051306 | Apoptosis and neurologic disease |
| Q36201880 | Apoptosis in amyotrophic lateral sclerosis--what is the evidence? |
| Q34352949 | Apoptosis in amyotrophic lateral sclerosis: a review of the evidence. |
| Q34068965 | Apoptosis in the nervous system |
| Q38198723 | Apoptosis signal-regulating kinase 1 as a therapeutic target |
| Q28585525 | Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis |
| Q43662965 | Bcl-2 expression by retrograde transport of adenoviral vectors with Cre-loxP recombination system in motor neurons of mutant SOD1 transgenic mice. |
| Q44577696 | Bcl-2 expression using retrograde transport of adenoviral vectors inhibits cytochrome c-release and caspase-1 activation in motor neurons of mutant superoxide dismutase 1 (G93A) transgenic mice |
| Q35580300 | Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis |
| Q73262534 | Caspase-1 and caspase-8 cleave and inactivate cellular parkin |
| Q45067699 | Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity |
| Q38024075 | Caspase-1: is IL-1 just the tip of the ICEberg? |
| Q50651302 | Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. |
| Q34733021 | Caspases on the brain |
| Q44376552 | Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. |
| Q59544343 | Chapter 11 Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis |
| Q57499026 | Chapter 21 Disease-Modifying Therapies in Motor Neuron Disorders: The Present Position and Potential Future Developments |
| Q59544347 | Chapter 9 Cellular Biological Effects of Copper/Zinc Superoxide Dismutase Mutations |
| Q42853712 | Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis |
| Q35003859 | Chemical genetic screening approaches to neurobiology |
| Q36314443 | Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future |
| Q40323686 | Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. |
| Q43566872 | Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations |
| Q73315751 | Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis |
| Q28591963 | Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions |
| Q30865041 | Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays |
| Q34141572 | Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity |
| Q35764591 | Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene |
| Q34547620 | Familial amyotrophic lateral sclerosis |
| Q34509807 | Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics |
| Q54977066 | High-Frequency Repetitive Magnetic Stimulation Enhances the Expression of Brain-Derived Neurotrophic Factor Through Activation of Ca2+-Calmodulin-Dependent Protein Kinase II-cAMP-Response Element-Binding Protein Pathway. |
| Q40853966 | In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients. |
| Q37931100 | In vivo and in vitro determination of cell death markers in neurons |
| Q60010618 | In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/ interleukin-1β-converting enzyme |
| Q37857439 | Induced pluripotent stem cells: a new revolution for clinical neurology? |
| Q52544555 | Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. |
| Q64901156 | Inflammasomes in neuroinflammatory and neurodegenerative diseases. |
| Q33664711 | Inflammation in ALS and SMA: sorting out the good from the evil |
| Q28533850 | Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase |
| Q38223011 | Innate immune activation in neurodegenerative disease |
| Q73818576 | Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients |
| Q37100241 | Interleukin-1beta: a bridge between inflammation and excitotoxicity? |
| Q39494190 | Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia |
| Q54625109 | Is motoneuronal cell death in amyotrophic lateral sclerosis apoptosis? |
| Q38750254 | Isolation and culture of postnatal spinal motoneurons |
| Q73102517 | Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease |
| Q36045308 | Measures and markers in amyotrophic lateral sclerosis |
| Q33878376 | Metals and neuroscience. |
| Q37490746 | Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding |
| Q36565597 | Mitochondria in amyotrophic lateral sclerosis: a trigger and a target |
| Q37588819 | Mitochondrial dysfunction in amyotrophic lateral sclerosis. |
| Q33208192 | Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis |
| Q34711201 | Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior |
| Q35489359 | Molecular and cellular pathways of neurodegeneration in motor neurone disease |
| Q36573336 | Molecular biology of amyotrophic lateral sclerosis: insights from genetics |
| Q48356347 | Molecular mechanisms of neuronal death in the dorsal lateral geniculate nucleus following visual cortical lesions. |
| Q33807850 | More than one way to die: apoptosis, necrosis and reactive oxygen damage |
| Q35623262 | Multidisciplinary Interventions in Motor Neuron Disease |
| Q37411790 | Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities |
| Q36858699 | Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death |
| Q34119497 | Neuroprotection by caspase inhibitors |
| Q30968664 | Novel drug development for amyotrophic lateral sclerosis |
| Q37954043 | Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases |
| Q74550312 | Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS |
| Q35688213 | Potential new strategies to prevent the development of diabetic retinopathy |
| Q34831541 | Programmed cell death in amyotrophic lateral sclerosis |
| Q35092261 | Prospects for antiapoptotic drug therapy of neurodegenerative diseases |
| Q33213321 | Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations |
| Q30974357 | REST and CoREST modulate neuronal subtype specification, maturation and maintenance |
| Q36854466 | RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells |
| Q43737204 | Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide. |
| Q94029459 | Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease |
| Q35036503 | Recent advances in amyotrophic lateral sclerosis research |
| Q74411605 | Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis |
| Q35910747 | Role of DNA mismatch repair in apoptotic responses to therapeutic agents |
| Q36320449 | Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates. |
| Q34553806 | Superoxide dismutase and the death of motoneurons in ALS. |
| Q34463760 | Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration |
| Q48214988 | Temporal profile of expression and cellular localization of inducible nitric oxide synthase, interleukin-1beta and interleukin converting enzyme after cryogenic lesion of the rat parietal cortex |
| Q22254013 | The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells |
| Q34993111 | The structural biochemistry of the superoxide dismutases. |
| Q58119582 | Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients |
| Q28506929 | X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration |
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