Multi-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB models

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Multi-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB models is …
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scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1276784T
P356DOI10.1371/JOURNAL.PONE.0176784
P932PMC publication ID5409163
P698PubMed publication ID28453555

P50authorAlexander GintsburgQ56820635
Vladimir A. GushchinQ41544493
P2093author name stringV G Lunin
A V Demidenko
A P Tkachuk
V D Potapov
P2860cites workA multistage tuberculosis vaccine that confers efficient protection before and after exposure.Q54391413
Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimenQ57100109
TB vaccine failure was predictableQ74440933
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Recombinant bacille Calmette-Guerin coexpressing Ag85b, CFP10, and interleukin-12 elicits effective protection against Mycobacterium tuberculosis.Q30372324
Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6.Q34007101
Variation in protection by BCG: implications of and for heterologous immunityQ34288541
Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up studyQ34318665
Error bars in experimental biologyQ34578493
Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trialQ34663035
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection.Q34804956
Subunit vaccine consisting of multi-stage antigens has high protective efficacy against Mycobacterium tuberculosis infection in miceQ34965575
Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in MiceQ35670390
The importance of adjuvant formulation in the development of a tuberculosis vaccineQ35783475
Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune ResponsesQ36020045
TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stressQ36156486
Recombinant domains III of Tick-Borne Encephalitis Virus envelope protein in combination with dextran and CpGs induce immune response and partial protectiveness against TBE virus infection in miceQ36157927
The success and failure of BCG - implications for a novel tuberculosis vaccineQ36191944
A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continentsQ36338571
Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogensQ36500269
Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidatesQ36909492
Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 TrialQ37008729
Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lungQ37666257
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Targeting the C-type lectins-mediated host-pathogen interactions with dextranQ38249917
Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31.Q38444246
Nanoengineering of vaccines using natural polysaccharides.Q38517950
Duration of BCG protection against tuberculosis and change in effectiveness with time since vaccination in Norway: a retrospective population-based cohort studyQ39302030
Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: the BCG-REVAC cluster-randomised trialQ39404079
Prime-boost vaccination with Bacillus Calmette Guerin and a recombinant adenovirus co-expressing CFP10, ESAT6, Ag85A and Ag85B of Mycobacterium tuberculosis induces robust antigen-specific immune responses in miceQ40952119
The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trialQ41181011
Adjuvants--a classification and review of their modes of actionQ41461373
Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infectionQ44467383
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteersQ45233558
Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing.Q46634611
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)e0176784
P577publication date2017-04-28
P1433published inPLOS OneQ564954
P1476titleMulti-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB models
P478volume12

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cites work (P2860)
Q92597111Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity
Q89820519Clinical Development of New TB Vaccines: Recent Advances and Next Steps
Q89514589The status of tuberculosis vaccine development

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