The status of tuberculosis vaccine development

scientific article published on 31 January 2020

The status of tuberculosis vaccine development is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S1473-3099(19)30625-5
P698PubMed publication ID32014117

P2093author name stringDavid M Lewinsohn
Ole F Olesen
Nick Drager
Lewis K Schrager
Johan Vekemens
P2860cites workHuman CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokinesQ24316479
Tuberculosis vaccines and prevention of infectionQ26782022
Recent advances in the development of vaccines for tuberculosisQ26796440
CD1 and mycobacterial lipids activate human T cellsQ26863207
Nonclassical T cells and their antigens in tuberculosisQ27007035
MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosisQ27016137
Quest for correlates of protection against tuberculosisQ28084282
A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy dataQ28383049
Mortality among MDR-TB cases: comparison with drug-susceptible tuberculosis and associated factorsQ28544684
The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical ModellingQ30244104
Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkersQ30403003
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activityQ33535876
Treatment practices, outcomes, and costs of multidrug-resistant and extensively drug-resistant tuberculosis, United States, 2005-2007.Q33577145
Multi-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB modelsQ33614952
Safety and immunogenicity of an inactivated whole cell tuberculosis vaccine booster in adults primed with BCG: A randomized, controlled trial of DAR-901.Q33675370
Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up studyQ34318665
Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countriesQ34441930
Modeling tuberculosis in nonhuman primatesQ34930509
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infectionQ35015787
The dynamics of QuantiFERON-TB gold in-tube conversion and reversion in a cohort of South African adolescentsQ35261953
Inherited and acquired immunodeficiencies underlying tuberculosis in childhoodQ35510477
Animal models of tuberculosis: Guinea pigsQ35663870
Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosisQ35771345
Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infectionQ35840672
Serial testing for tuberculosis: can we make sense of T cell assay conversions and reversions?Q35840685
A Novel MVA-Based Multiphasic Vaccine for Prevention or Treatment of Tuberculosis Induces Broad and Multifunctional Cell-Mediated Immunity in Mice and PrimatesQ35849628
Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, UgandaQ36112137
Protection by novel vaccine candidates, Mycobacterium tuberculosis ΔmosR and ΔechA7, against challenge with a Mycobacterium tuberculosis Beijing strainQ36145657
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosisQ36169358
B cells and antibodies in the defense against Mycobacterium tuberculosis infectionQ36238031
Acquired Resistance to Bedaquiline and Delamanid in Therapy for TuberculosisQ36377090
Immunization by a bacterial aerosolQ36534318
M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB AntigensQ36594099
MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infectionQ37104082
Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunityQ37160776
Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adultsQ37186951
Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populationsQ37433271
New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine ProfilesQ37445202
Systematic review of mathematical models exploring the epidemiological impact of future TB vaccinesQ37473293
Heterologous prime-boost vaccination.Q37509586
Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosisQ38135954
Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trialsQ38171263
Early clearance of Mycobacterium tuberculosis: a new frontier in preventionQ38206209
Antigens for CD4 and CD8 T cells in tuberculosisQ38213801
Aerosol immunisation for TB: matching route of vaccination to route of infectionQ38338183
Innovative clinical trial designs to rationalize TB vaccine developmentQ38388503
The burgeoning family of unconventional T cellsQ38611633
Mycobacterium indicus pranii as a booster vaccine enhances BCG induced immunity and confers higher protection in animal models of tuberculosis.Q38793308
Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: the BCG-REVAC cluster-randomised trialQ39404079
Early Changes by (18)Fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacterium tuberculosis infection in cynomolgus macaquesQ39550322
Double-blind, randomized, placebo-controlled Phase I Clinical Trial of the therapeutical antituberculous vaccine RUTI.Q39935921
Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human TuberculosisQ39993507
Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques.Q40826365
Efficacy of parainfluenza virus 5 (PIV5)-based tuberculosis vaccines in miceQ40916919
First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adultsQ41148040
Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protectionQ41335764
Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.Q41411454
What Have We Learnt about BCG Vaccination in the Last 20 Years?Q41684091
The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy TestingQ41836016
CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigenQ41939036
The duration of protection of school-aged BCG vaccination in England: a population -based case-control studyQ41986442
A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-GuerinQ42018546
An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infectionQ42278752
Polyfunctional CD4+ T Cells As Targets for Tuberculosis VaccinationQ42373425
Toward Tuberculosis Vaccine Development: Recommendations for NHP Study DesignQ46296097
Boosting with recombinant MVA expressing M. tuberculosis α-crystallin antigen augments the protection imparted by BCG against tuberculosis in guinea pigsQ47155139
Controlled human infections: A report from the controlled human infection models workshop, Leiden University Medical Centre 4-6 May 2016.Q47210236
Tuberculosis vaccines: Opportunities and challengesQ47552546
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.Q47553632
MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic.Q47658864
Human type 5 adenovirus-based tuberculosis vaccine: is the respiratory route of delivery the future?Q48879396
Next-Generation Vaccines Based on Bacille Calmette-Guérin.Q49829375
Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial.Q52623020
A multistage tuberculosis vaccine that confers efficient protection before and after exposure.Q54391413
Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination.Q55617820
New Promise for Vaccines against TuberculosisQ57788338
Metabolite changes in blood predict the onset of tuberculosisQ59791316
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaquesQ62737827
Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trialQ64080157
A Case for Antibodies as Mechanistic Correlates of Immunity in TuberculosisQ64260919
Rational approach to selection and clinical development of TB vaccine candidatesQ83730558
WHO preferred product characteristics for new vaccines against tuberculosisQ90669089
Final Analysis of a Trial of M72/AS01E Vaccine to Prevent TuberculosisQ90985117
Catastrophic costs of treating drug resistant TB patients in a tertiary care hospital in IndiaQ91852620
P433issue3
P921main subjecttuberculosisQ12204
P304page(s)e28-e37
P577publication date2020-01-31
P1433published inLancet Infectious DiseasesQ15724248
P1476titleThe status of tuberculosis vaccine development
P478volume20

Reverse relations

cites work (P2860)
Q99592919Bacille Calmette Guérin (BCG) and new TB vaccines: Specific, cross-mycobacterial and off-target effects
Q97565455Bacillus Calmette-Guérin vaccine, antimalarial, age and gender relation to COVID-19 spread and mortality
Q104456936The TB vaccine development pathway - An innovative approach to accelerating global TB vaccine development

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