Caspase-9: structure, mechanisms and clinical application

scientific article

Caspase-9: structure, mechanisms and clinical application is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.15098
P8608Fatcat IDrelease_m7vgj425gjbbjlm4rstmqryopm
P932PMC publication ID5410359
P698PubMed publication ID28177918

P2093author name stringYan Liu
Qiang Li
Ting Zhao
Ping Li
Libin Zhou
Pengcheng Zhang
Xiongxiong Liu
Xiaogang Zheng
P2860cites workStructural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1Q22010148
Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteinsQ24290511
Mechanism of XIAP-mediated inhibition of caspase-9Q24296916
HBXIP functions as a cofactor of survivin in apoptosis suppressionQ24303423
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timerQ24316930
X-linked IAP is a direct inhibitor of cell-death proteasesQ24318710
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damageQ24338416
A quantitative atlas of mitotic phosphorylationQ24646817
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activationQ24798064
Dimer formation drives the activation of the cell death protease caspase 9Q27636617
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosisQ28139969
Mechanisms of caspase activationQ28187994
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosisQ28204205
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexesQ28354545
Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosisQ28513434
DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3Q28513460
Inducible apoptosis as a safety switch for adoptive cell therapyQ29617710
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9Q29618617
Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim.Q30413140
S-Nitrosylation of mitochondrial caspasesQ30441958
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.Q30797347
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibitionQ33251282
Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.Q50507805
Caspase 9 promoter polymorphisms and risk of primary lung cancer.Q53597510
Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cells.Q53811624
Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis.Q54374974
Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.Q54379655
Effects of caspase-9 and survivin gene polymorphisms in pancreatic cancer risk and tumor characteristics.Q54434279
Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerizationQ71824439
Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9Q77815886
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometryQ79491768
Association between Caspase-9 promoter region polymorphisms and discogenic low back painQ82522458
An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune diseaseQ43527563
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.Q43860697
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina developmentQ43971025
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosisQ44104444
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancerQ44123699
Role of caspase-9 in the effector caspases and genome expressions, and growth of bovine skeletal myoblastsQ44260481
Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activationQ44302132
SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsivenessQ44917660
Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c.Q45259224
Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.Q45295534
Cytochrome C and caspase-9 expression in Huntington's diseaseQ45306362
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemiaQ45882160
The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125.Q46847481
Caspase 9 and caspase 8 gene polymorphisms and susceptibility to bladder cancer in north Indian populationQ47890688
CASP-9: A susceptibility locus for multiple sclerosis in Italy.Q48025575
Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgeneQ33781162
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.Q33951635
Regulation of the Apaf-1-caspase-9 apoptosomeQ34129476
hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processingQ34245430
Caspase activation: revisiting the induced proximity modelQ34328287
Adoptive T-cell therapy: adverse events and safety switchesQ34511623
Molecular determinants of caspase-9 activation by the Apaf-1 apoptosomeQ34581367
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30aQ34685905
microRNA-24a is required to repress apoptosis in the developing neural retinaQ34976201
SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cellsQ35118687
Caspase-9 and APAF-1 form an active holoenzymeQ35210359
Caspase-9 regulation: an updateQ35802114
Aberrant and alternative splicing in cancerQ35936123
Synthetic activation of caspases: artificial death switchesQ36007918
Inhibition of caspase 9 and not caspase 8 mediated apoptosis may determine clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomasQ36117986
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9Q36618628
hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP LQ36708640
The apoptosome: signalling platform of cell deathQ36766418
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.Q37605158
The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosomeQ37992385
HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activationQ38839315
Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibitionQ38946336
Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.Q39408105
Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stressQ39890975
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmineQ39915098
A non-apoptotic role for caspase-9 in muscle differentiationQ39924087
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.Q39984111
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosisQ40139701
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.Q40675295
Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell lineQ40757141
Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodiesQ40773080
Caspase-9 can be activated without proteolytic processingQ40966257
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosisQ40968400
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosisQ40980300
Differential requirement for caspase 9 in apoptotic pathways in vivo.Q41015558
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safetyQ41179125
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerizationQ41187958
Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxideQ41688613
An inducible caspase 9 safety switch for T-cell therapyQ41768001
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantationQ41953436
p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stressQ42456617
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.Q42800979
Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graftQ43513924
MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cellsQ43522938
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue14
P407language of work or nameEnglishQ1860
P921main subjecttransport proteinQ2111029
enzymeQ8047
peptideQ172847
P304page(s)23996-24008
P577publication date2017-02-04
2017-04-04
P1433published inOncotargetQ1573155
P1476titleCaspase-9: structure, mechanisms and clinical application
P478volume8

Reverse relations

cites work (P2860)
Q89719621Calcium Delivery by Electroporation Induces In Vitro Cell Death through Mitochondrial Dysfunction without DNA Damages
Q93127435Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells
Q47693943Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment
Q64054412Gene activation by a CRISPR-assisted enhancer
Q92740132Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons
Q98177663Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells
Q98778880Hydrogen peroxide induces nucleus pulposus cell apoptosis by ATF4/CHOP signaling pathway
Q55343616Inhibitory effects of isocryptotanshinone on gastric cancer.
Q47148226MOMP, cell suicide as a BCL-2 family business
Q91644609Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells
Q60302146Natural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer
Q57022956Proteases: Pivot Points in Functional Proteomics
Q47221866QiShenYiQi Pills, a Compound Chinese Medicine, Prevented Cisplatin Induced Acute Kidney Injury via Regulating Mitochondrial Function
Q54119547To die or not to die: death signaling in nonalcoholic fatty liver disease.
Q33821469YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells

Search more.