Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

scientific article (publication date: 7 August 1998)

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(00)81476-2
P3181OpenCitations bibliographic resource ID1874741
P698PubMed publication ID9708735

P50authorRichard FlavellQ2149481
Pasko RakicQ532002
P2093author name stringGu Y
Karasuyama H
Su MS
Kuida K
Taya C
Kuan CY
Haydar TF
P2860cites workNumbers, time and neocortical neuronogenesis: a general developmental and evolutionary modelQ40372315
Asymmetric division and polarity of neuroepithelial cells.Q41353316
Cytochrome c: can't live with it--can't live without it.Q41657950
Autoproteolytic activation of pro-caspases by oligomerizationQ47862735
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.Q52190101
A subset of p53-deficient embryos exhibit exencephalyQ72031963
Cell deaths in normal vertebrate ontogenyQ87311819
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosisQ24313625
X-linked IAP is a direct inhibitor of cell-death proteasesQ24318710
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blockedQ24318845
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Apoptosis in the pathogenesis and treatment of diseaseQ28235731
The CARD domain: a new apoptotic signalling motifQ28239887
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeQ28256420
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADQ28258328
Mechanisms and Functions of Cell DeathQ28261655
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzymeQ28287610
Human ICE/CED-3 protease nomenclatureQ28293240
Specification of cerebral cortical areasQ28295048
Apoptosis by death factorQ28304002
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shockQ28307404
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesQ28506930
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric miceQ28593186
Caspases: killer proteasesQ29616315
Programmed cell death in animal developmentQ29616430
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosisQ29616513
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.Q33886507
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.Q33887952
An induced proximity model for caspase-8 activation.Q34065853
A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolutionQ34289050
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.Q34322094
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceQ34408475
Defects in regulation of apoptosis in caspase-2-deficient miceQ35198808
Cell death during development of the nervous systemQ37716922
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)325-37
P577publication date1998-08-07
P1433published inCellQ655814
P1476titleReduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
P478volume94

Reverse relations

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Q43764281Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells
Q48458778Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development.
Q73540307Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
Q47633429Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells.
Q27636617Dimer formation drives the activation of the cell death protease caspase 9
Q37845412Disintegration of the medial epithelial seam: is cell death important in palatogenesis?
Q57272486Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies
Q51091938Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
Q33958788Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids
Q46543702Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim.
Q43882753Diversity of the apoptotic response to chemotherapy in childhood leukemia
Q45267818Do inducers of apoptosis trigger caspase-independent cell death?
Q34096352Drug discovery opportunities from apoptosis research
Q48224018Dual behavior of N-acetylcysteine during ethanol-induced oxidative stress in embryonic chick brains.
Q43275683Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates
Q30865918Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions
Q84971423Dynamics of caspase-3 activation and inhibition in embryonic micromasses evaluated by a photon-counting chemiluminescence approach
Q34658574Dysregulation of apoptosis genes in hematopoietic malignancies.
Q78968663ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation
Q38905560Effect of chronic pesticide exposure on murine cornea: a histopathological, cytological and flow cytometric approach to study ocular damage by xenobiotics.
Q77918828Effect of p21waf1/cip1 transgene on radiation induced apoptosis in T cells
Q33924333Effective blockage of both the extrinsic and intrinsic pathways of apoptosis in mice by TAT-crmA
Q38781385Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b.
Q48903959Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Q47617801Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Q33816829Endogenous inhibitors of caspases
Q28206238Endonuclease G is an apoptotic DNase when released from mitochondria
Q91941027Endoplasmic reticulum and Golgi stress in microcephaly
Q52577797Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.
Q44173100Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells
Q36473607EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development
Q28594694Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
Q35964742Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
Q36702308Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster
Q28209183Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Q30408769Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Q48599767Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses.
Q28258984Evolution of the neocortex: a perspective from developmental biology
Q34764065Evolving concepts of cortical radial and areal specification
Q28504797Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
Q33656126Excitotoxins in neuronal apoptosis and necrosis
Q34146813Executionary pathway for apoptosis: lessons from mutant mice
Q27303642Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart
Q44132582Exogenous smac induces competence and permits caspase activation in sympathetic neurons.
Q28219614Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis
Q51425342Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Q40781435Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates
Q40794689FGF induces a switch in death receptor pathways in neuronal cells.
Q42150350Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain
Q42132563Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation
Q35253620Fas-associated factor 1 as a regulator of olfactory axon guidance
Q28589482Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors
Q35152994Fine-tuning of neurogenesis is essential for the evolutionary expansion of the cerebral cortex
Q42504826Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways.
Q34098735Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.
Q41702049Formation of cortical fields on a reduced cortical sheet.
Q43830916Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death
Q37424995Fumigaclavine C from a marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells.
Q33558259Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo
Q90485436Functional integration of "undead" neurons in the olfactory system
Q45875109Functions of the AP-2α gene in activating apoptosis and inhibiting proliferation of gastric cancer cells both in vitro and in vivo
Q36326358GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo
Q33713375Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling
Q30657334Gene trap: a way to identify novel genes and unravel their biological function
Q43809110Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats
Q44658237Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death
Q34170792Genetic analysis of apoptotic and survival signals
Q34540789Genetic analysis of the mammalian cell death machinery
Q37158051Genetic causes of microcephaly and lessons for neuronal development
Q51864092Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.
Q33713368Genetic models of abnormal apoptosis in lymphocytes
Q48173288Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects.
Q34552276Genetics and development of neural tube defects.
Q34250267Genetics of central nervous system developmental disorders.
Q60960849Genomic mosaicism in the developing and adult brain
Q37542684Glucocorticoid Induced Cerebellar Toxicity in the Developing Neonate: Implications for Glucocorticoid Therapy during Bronchopulmonary Dysplasia
Q35043097Glucocorticoid receptor stimulation and the regulation of neonatal cerebellar neural progenitor cell apoptosis
Q35831218Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance.
Q36628641Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes
Q36325611Glucocorticoids in T cell apoptosis and function.
Q44590966Glutathione Peroxidase Overexpression Inhibits CytochromecRelease and Proapoptotic Mediators to Protect Neurons From Experimental Stroke
Q40837904Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition
Q28655454Growth and folding of the mammalian cerebral cortex: from molecules to malformations
Q35685294Growth and guidance cues for regenerating axons: where have they gone?
Q24618872Guidance molecules in axon pruning and cell death
Q39979531HDAC4 inhibits cell-cycle progression and protects neurons from cell death
Q36768058HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans.
Q51988213HSP110, caspase-3 and -9 expression in physiological apoptosis and apoptosis induced by in vivo embryonic exposition to all-trans retinoic acid or irradiation during early mouse eye development.
Q38834715HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation
Q52316687HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC.
Q44283578Head size constrains forebrain development and evolution in ray-finned fishes
Q73177747Hidden powers of the mitochondria
Q81494058Histological analyses of normally grown, fertile Apaf1-deficient mice
Q48119260Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5.
Q33992348Hormonal regulation of physiological cell turnover and apoptosis
Q34931816How death shapes life during development
Q49922823How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Q24631607How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals
Q24534085Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis
Q48091564Human brain of preterm infants after hypoxic-ischaemic injuries: no evidence of a substantial role for apoptosis by using a fine-tuned ultrasound-guided neuropathological analysis
Q57839949Huntingtin proteolysis in Huntington disease
Q73082173Hydrogen peroxide inhibits activation, not activity, of cellular caspase-3 in vivo
Q79991488Hypoxia-induced cell death and activation of pro- and anti-apoptotic proteins in developing chick optic lobe
Q24804177Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways
Q33770270Hypoxic-ischemic encephalopathy in the term infant
Q73978686IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma
Q51954200IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis.
Q39754898Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns?
Q40784940Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development
Q37415041Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.
Q87904878Identification of transcripts potentially involved in neural tube closure using RNA sequencing
Q54389891Immune clearance gastric carcinoma cells in ascites by activating caspase-9-induced apoptosis.
Q35195215Immune disorders caused by defects in the caspase cascade
Q35145656In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS.
Q44247683In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons
Q28507997Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis
Q28580707Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis
Q46175954Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice
Q79696856Increased proliferation of CD8+ T cells in SAP-deficient mice is associated with impaired activation-induced cell death
Q28755819Incudomalleal joint formation: the roles of apoptosis, migration and downregulation
Q28272882Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein
Q28114555Induction of Expansion and Folding in Human Cerebral Organoids
Q35043420Induction of apoptosis in cancer: new therapeutic opportunities
Q44382910Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase/catalase mimetic
Q46375880Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types
Q45405226Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection.
Q22010404Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
Q33890314Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors
Q46542928Inhibition of apoptosome activation protects injured motor neurons from cell death
Q42800979Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.
Q44131363Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.
Q40943846Inhibition of virus-induced neuronal apoptosis by Bax.
Q40724758Inhibitor specificity of recombinant and endogenous caspase-9.
Q37174527Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases.
Q34223547Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis
Q64448633Insights into T-Cell Development from Studies Using Transgenic and Knockout Mice
Q53371634Insulin-like growth factor-1 inhibits 6-hydroxydopamine-mediated endoplasmic reticulum stress-induced apoptosis via regulation of heme oxygenase-1 and Nrf2 expression in PC12 cells.
Q44205869Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.
Q33748270Integrated genomics of susceptibility to alkylator-induced leukemia in mice
Q48198830Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia
Q37845411Interdigital cell death function and regulation: new insights on an old programmed cell death model
Q26859279Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insight into tissue mechanics
Q90781282Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development
Q36604805Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors
Q73472953Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus
Q34490979Involvement of mitochondria in apoptosis
Q40047545Involvement of mitochondria-caspase pathway in Hemoporfin-mediated cell death
Q44391043Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
Q36375843Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy
Q43722438Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells
Q43583342Irradiation of mitochondria initiates apoptosis in a cell free system
Q34293956Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?
Q36016453Iso-suillin from Suillus flavus Induces Apoptosis in Human Small Cell Lung Cancer H446 Cell Line
Q37947994It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Q34305683Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.
Q28764730Karl Pribram, The James Arthur lectures, and what makes us human
Q49865560Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.
Q31926029Key targets for the execution of radiation-induced tumor cell apoptosis: the role of p53 and caspases
Q37848690Kidney and urinary tract development: an apoptotic balancing act.
Q38009194Killing a cancer: what are the alternatives?
Q33354609Laminin enhances the growth of human neural stem cells in defined culture media
Q34282245Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone
Q33257222Laser scanning cytometry in the characterization of the proapoptotic effects of transiently transfected genes in cerebellar granule neurons
Q47373804Less is more: progenitor death and cortical size
Q34097412Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.
Q34046206Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS.
Q36658110Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro.
Q35641895Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death
Q37128350Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
Q40245914Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis
Q40213057Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization
Q53926583Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line.
Q33928666Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Q48633296Loss of notch activity in the developing central nervous system leads to increased cell death.
Q41776106Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways
Q33796094Lysosome dysfunction triggers Atg7-dependent neural apoptosis
Q36302900Mammalian initiator apoptotic caspases
Q44844420Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice
Q90440542Maternal vitamin B12 deficiency in rats alters DNA methylation in metabolically important genes in their offspring
Q43066434Mathematical modeling supports substantial mouse neural progenitor cell death
Q34067880Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
Q58553823Mcl-1 and Bcl-xL are essential for survival of the developing nervous system
Q43128865Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage
Q38059700Mdm2 and MdmX as Regulators of Gene Expression
Q40531082Mechanism of Fas-mediated cell death and its enhancement by TNF-alpha in human salivary gland adenocarcinoma cell line HSG.
Q30832096Mechanism of action for N-substituted benzamide-induced apoptosis
Q48290587Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx
Q36197618Mechanism of caspase-9 activation during hypoxia in the cerebral cortex of newborn piglets: the role of Src kinase
Q34022496Mechanism of tyrosine phosphorylation of procaspase-9 and Apaf-1 in cytosolic fractions of the cerebral cortex of newborn piglets during hypoxia
Q37943258Mechanisms and pathways of growth failure in primordial dwarfism.
Q42611206Mechanisms of T-cell Apoptosis Induced by Glucocorticoids
Q56609201Mechanisms of apoptosis
Q73544921Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation
Q35120707Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
Q36398098Mechanisms of early brain injury after subarachnoid hemorrhage
Q36045199Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies
Q27919627Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases
Q33944933Mechanisms of programmed cell death in the developing brain
Q37341018Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis
Q33935219Mechanisms underlying hypoxia-induced neuronal apoptosis
Q38969211Metabolic Regulation of Apoptosis in Cancer.
Q35190373MicroRNA gene expression signatures in the developing neural tube
Q50326592MicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation-induced apoptosis.
Q24321570Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors
Q34649089Microglia regulate the number of neural precursor cells in the developing cerebral cortex
Q33816824Mitochondria and apoptosis: HQ or high-security prison?
Q90859789Mitochondria as multifaceted regulators of cell death
Q46598275Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice
Q38235124Mitochondria-mediated apoptosis in mammals
Q55920332Mitochondrial activation of apoptosis
Q37691346Mitochondrial control of caspase-dependent and -independent cell death
Q48847340Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke.
Q44636686Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release
Q37526353Mitochondrial membrane permeabilization in neuronal injury
Q47073934Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development
Q42792442Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis
Q35046100Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
Q35469289Molecular mechanism of size control in development and human diseases
Q37027281Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities
Q43825779Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
Q36033294Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis
Q48356347Molecular mechanisms of neuronal death in the dorsal lateral geniculate nucleus following visual cortical lesions.
Q30306313Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
Q47628054Molecular requirements for the combined effects of TRAIL and ionising radiation
Q37134181Morphological characteristics of apoptosis and its significance in neurogenesis
Q63408387Mostly dead
Q35027903Motor neuron trophic factors: therapeutic use in ALS?
Q74014346Mouse mammary gland involution is associated with cytochrome c release and caspase activation
Q34266817Mouse models of cell death
Q34326024Multiple functions of BCL-2 family proteins
Q34608399Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.
Q37396889Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant
Q47131885Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis
Q24554454NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
Q35202849Nature versus nurture revisited: an old idea with a new twist
Q64814767Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Q54981573Necroptosis in development and diseases.
Q39044997Necroptosis in development, inflammation and disease.
Q33782491Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
Q34565433Neural stem cells and regulation of cell number
Q30441111Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
Q87906376Neuronal Cell Death
Q37644193Neuronal caspase-3 signaling: not only cell death
Q33547888Neuronal cell death: a demise with different shapes.
Q36045204Neuronal death/survival signaling pathways in cerebral ischemia
Q34201997Neuronal life and death: an essential role for the p53 family
Q34687686Neurons bearing presenilins: weapons for defense or suicide?
Q34119497Neuroprotection by caspase inhibitors
Q30857660Neuroprotection by the inhibition of apoptosis
Q34083682Neurotransmitters and apoptosis in the developing brain
Q37998778Neurotrophins and cell death.
Q92363377New insights into the development of the human cerebral cortex
Q27011322New roles for old enzymes: killer caspases as the engine of cell behavior changes
Q34305204Nitric oxide-induced apoptosis in tumor cells
Q22010046Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
Q39140585Non-apoptotic cell death in animal development
Q37695139Non-caspase proteases: triggers or amplifiers of apoptosis?
Q37147746Noncanonical cell death programs in the nematode Caenorhabditis elegans
Q34301992Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.
Q42823834Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.
Q34126046Nuclear hormone receptors in T lymphocytes
Q46921316Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function
Q47793462Nuclear translocation of cytochrome c during apoptosis.
Q28472140ON/OFF and beyond--a boolean model of apoptosis
Q54410209Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.
Q59783959Oligodendrocyte apoptosis mediated by caspase activation
Q39666776Optimizing photodynamic therapy by liposomal formulation of the photosensitizer pyropheophorbide-a methyl ester: In vitro and ex vivo comparative biophysical investigations in a colon carcinoma cell line
Q40850451Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis
Q22008727Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
Q36696631Organ size control by Hippo and TOR pathways.
Q39059494Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex
Q40185578Overexpression of caspase-9 triggers its activation and apoptosis in vitro.
Q43833745Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation.
Q57173169Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression
Q74341665Oxidative stress and apoptosis
Q36161829Oxidative stress and neuronal death/survival signaling in cerebral ischemia
Q28084613Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity
Q29619852Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Q79881731Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9
Q36961965Pathophysiological Significance of Hepatic Apoptosis
Q37631575Pathophysiology and the Monitoring Methods for Cardiac Arrest Associated Brain Injury
Q37574787Pathophysiology of acute kidney injury
Q36166503Pathways of apoptosis and importance in development.
Q47074392Peroxisome proliferator-activated receptor-γ enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4.
Q33601950Perspective: virus infections and the death of neurons
Q93052161Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
Q39696436Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.
Q26853192Photoreceptor cell death and rescue in retinal detachment and degenerations
Q34147269Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody
Q44401713Pituitary adenylate cyclase‐activating polypeptide prevents C2‐ceramide‐induced apoptosis of cerebellar granule cells
Q51548450Placental bed apoptosis is increased in pregnant women with pre-eclampsia versus normotensive pregnant women.
Q42055819Plasmatocytes from the moth Pseudoplusia includens induce apoptosis of granular cells
Q33390267Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway
Q34054886Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies.
Q48179334Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study
Q43861757Pre-processed caspase-9 contained in mitochondria participates in apoptosis
Q73616626Prediction of the tertiary structure of a caspase-9/inhibitor complex
Q43569874Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells
Q36328615Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release
Q36392288Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis.
Q30865931Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).
Q24298402Proapoptotic BAX and BAK control multiple initiator caspases
Q28363890Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
Q42378443Proapoptotic function of deubiquitinase DUSP31 in Drosophila.
Q37845409Programmed cell death during postnatal development of the rodent nervous system
Q52118783Programmed cell death in the neurulating embryo is prevented by the chaperone heat shock cognate 70.
Q48829797Programmed cell death of developing mammalian neurons after genetic deletion of caspases.
Q36316322Programmed cell death of embryonic motoneurons triggered through the Fas death receptor
Q34303405Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
Q34747476Proliferation and apoptosis in the developing human neocortex.
Q39268374Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage
Q38663181Protease signaling in animal and plant-regulated cell death
Q33927179Proteases for cell suicide: functions and regulation of caspases
Q52537613Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.
Q46319973Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis
Q40735912Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
Q33410395Protein evolution on a human signaling network
Q64092700Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats
Q57802350RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death
Q37251495REVIEW paper: pathophysiology of myocardial reperfusion injury: the role of genetically engineered mouse models
Q33552631RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats
Q41772077Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly
Q49910228Rare mutations inapoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects.
Q35568820Reactive Oxygen Radicals and Pathogenesis of Neuronal Death After Cerebral Ischemia
Q75233308Reactive oxygen species regulate quiescent T-cell apoptosis via the BH3-only proapoptotic protein BIM
Q33535174Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins
Q35036503Recent advances in amyotrophic lateral sclerosis research
Q34502160Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
Q28354545Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes
Q73088831Reduction of endogenous transforming growth factors beta prevents ontogenetic neuron death
Q36092826Redundant cell death mechanisms as relics and backups
Q24321468Regulation of XIAP translation and induction by MDM2 following irradiation
Q39890975Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress
Q33606109Regulation of caspase activation in apoptosis: implications in pathogenesis and treatment of disease
Q24675830Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
Q34117899Regulation of death receptor-mediated apoptosis pathways
Q24673747Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)
Q35743096Regulation of the apoptosis-necrosis switch
Q52564437Regulation of the expression of tumor necrosis factor‑related genes by abnormal histone H3K27 acetylation: Implications for neural tube defects.
Q36368602Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
Q43960599Release of cytochrome c into the extracellular space contributes to neuronal apoptosis induced by staurosporine
Q30512263Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
Q40634325Ribosome-inactivating protein and apoptosis: abrin causes cell death via mitochondrial pathway in Jurkat cells
Q24632980Ripped to death
Q43658606Role of DNA-dependent protein kinase in neuronal survival.
Q36934716Role of Smac/DIABLO in cancer progression
Q54059288Role of c-jun expression increased by heat shock- and ceramide-activated caspase-3 in HL-60 cell apoptosis. Possible involvement of ceramide in heat shock-induced apoptosis.
Q43937484Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain
Q40185447Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release
Q90593452Role of cytochrome c in modulating chromium-induced oxidative stress in Oryza sativa
Q35212533Role of factors downstream of caspases in nuclear disassembly during apoptotic execution.
Q41924709Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.
Q37030395Role of intermediate progenitor cells in cerebral cortex development
Q25257246Role of mechanical factors in the morphology of the primate cerebral cortex
Q33955146Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury
Q36000508Role of programmed cell death in normal neuronal development and function
Q35085408Roles of the mammalian subventricular zone in brain development
Q45230294Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells.
Q40602856S-Nitrosation regulates the activation of endogenous procaspase-9 in HT-29 human colon carcinoma cells
Q91816871Seasonal Variations in the Chemical Composition of Liangshan Olive Leaves and Their Antioxidant and Anticancer Activities
Q34212502Selected comparison of immune and nervous system development
Q28567192Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells
Q53343723Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.
Q59393051Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies
Q41476953Selective uptake of epidermal growth factor-conjugated gold nanoparticle (EGF-GNP) facilitates non-thermal plasma (NTP)-mediated cell death
Q55475629Sensitization to CD95 ligand-induced apoptosis in human glioma cells by hyperthermia involves enhanced cytochrome c release.
Q53586139Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
Q73984950Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity
Q35083240Sexual dimorphism in ischemic stroke: lessons from the laboratory
Q33289241Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
Q28142592Signal transduction by the JNK group of MAP kinases
Q34731231Signaling for survival and apoptosis in the immune system
Q33793237Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Q34563012Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
Q91651911Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1
Q92525864Siva plays a critical role in mouse embryonic development
Q39714230Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation
Q34788518Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis
Q27619762Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction
Q51687898Spatial growth of real-world networks.
Q42916419Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects
Q43514142Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production
Q49106082Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Q48524880Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.
Q24290945Structural basis for the inhibition of caspase-3 by XIAP
Q46536480Surviving the cytochrome seas.
Q38837843Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells.
Q41834899Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
Q40703254TGF-beta induces cell death in the oligodendroglial cell line OLI-neu
Q34542205TNF ligands and receptors--a matter of life and death
Q34565473TNF receptor subtype signalling: differences and cellular consequences
Q28142549TNF-induced signaling in apoptosis
Q39644786TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways.
Q35624736TRAIL, Bim, and thymic-negative selection
Q39753656TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Q33547792Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.
Q89840958Targeting apoptotic caspases in cancer
Q38626400Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor
Q34235924The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis.
Q28212977The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells
Q34648882The Apaf-1 apoptosome: a large caspase-activating complex
Q24316930The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
Q40885189The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin
Q35591695The Bcl-2 family: roles in cell survival and oncogenesis.
Q35031256The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
Q29614982The Bcl2 family: regulators of the cellular life-or-death switch
Q36846541The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
Q35561587The CD95 type I/type II model
Q36518331The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation
Q28548450The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway
Q44611170The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases
Q48219557The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
Q33361879The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle
Q37661170The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss.
Q39682487The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
Q33997832The apoptosome: heart and soul of the cell death machine
Q33908341The ced-8 gene controls the timing of programmed cell deaths in C. elegans.
Q37992385The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome
Q28512628The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
Q35586726The control of cell number during central nervous system development in flies and mice
Q41728640The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice.
Q36844137The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila
Q52973758The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes.
Q45247601The effects of hormones of the hypothalamo-hypophyseal-adrenal, renin-angiotensin, and thyroid hormone systems on the formation of dyscirculatory encephalopathy
Q90149948The essentials of developmental apoptosis
Q47595678The evolution of cortical development: the synapsid-diapsid divergence.
Q36799509The genomically mosaic brain: aneuploidy and more in neural diversity and disease
Q40860042The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors.
Q37152729The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?
Q51020805The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.
Q34466450The machinery of programmed cell death.
Q35831981The mitochondrial death pathway: a promising therapeutic target in diseases
Q36751667The molecular mechanisms that control function and death of effector CD4+ T cells
Q34002897The most unkindest cut of all: on the multiple roles of mammalian caspases
Q34555987The myc oncogene: MarvelouslY Complex
Q36521923The p53 family in nervous system development and disease
Q24301611The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis
Q35618322The p75 neurotrophin receptor: multiple interactors and numerous functions
Q24561863The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity
Q48733386The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma.
Q38697013The preventive effects of taurine on neural tube defects through the Wnt/PCP-Jnk-dependent pathway
Q36301514The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
Q35902423The protein structures that shape caspase activity, specificity, activation and inhibition
Q36805936The radial edifice of cortical architecture: from neuronal silhouettes to genetic engineering
Q28586611The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development
Q41837258The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
Q33781254The role of apoptosis in normal and abnormal embryonic development
Q44189407The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells
Q33686145The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
Q36602674The role of mitochondria in apoptosis*.
Q34859478The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
Q52623796The role of suboptimal mitochondrial function in vulnerability to post-traumatic stress disorder.
Q36913767The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury
Q52574307The third horseman takes wing.
Q33334247The transcription factor Nfix is essential for normal brain development
Q44278351The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways.
Q54078688The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.
Q33816812Thymocyte apoptosis
Q40783269Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis
Q46075225Thymosin β4 induces folding of the developing optic tectum in the chicken (Gallus domesticus).
Q33881268Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm
Q35743127Toxic proteins released from mitochondria in cell death
Q35209364Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools
Q34124193Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells
Q28592731Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
Q40300559Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
Q92617806Triptolide reduces proliferation and enhances apoptosis in drug-resistant human oral cancer cells
Q39987469Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.
Q41764558Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis
Q34071248Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB.
Q24804943Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells
Q34145910Two phylogenetic specializations in the human brain
Q42048093Type I interferon gene transfer sensitizes melanoma cells to apoptosis via a target activity on mitochondrial function
Q36538525UBE4B: a promising regulatory molecule in neuronal death and survival
Q39445447Uncouplers of oxidative phosphorylation can enhance a Fas death signal
Q94948758Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
Q38349516Upstream AUGs in embryonic proinsulin mRNA control its low translation level.
Q44630766VEIDase is a principal caspase-like activity involved in plant programmed cell death and essential for embryonic pattern formation.
Q33653453Viral modulation of the host response via crmA/SPI-2 expression.
Q37396234Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse
Q53294318Vitamin C protects against ethanol and PTZ-induced apoptotic neurodegeneration in prenatal rat hippocampal neurons.
Q53245187What's in a name? Would that which we call death by any other name be less tragic?
Q38577529Who lives and who dies: Role of apoptosis in quashing developmental errors
Q36370019Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription
Q39915491YAP regulates neural progenitor cell number via the TEA domain transcription factor
Q40415909Zinc protects renal function during cadmium intoxication in the rat.
Q43583209Zinc-mediated regulation of caspases activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos).
Q78019259[Apoptosis--what is it? Significance in coronary heart disease and myocardial infarct]
Q73539952[Physicopathologic mechanisms and methods of analysis of cellular apoptosis]
Q34462324beta-Cell death during progression to diabetes
Q34519958p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells.
Q57288790p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects
Q63408383p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation
Q34305233p53-dependent apoptosis pathways.
Q42454035p63 antagonizes p53 to promote the survival of embryonic neural precursor cells
Q24290118tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

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