Mechanisms of early brain injury after subarachnoid hemorrhage

scientific article published on 15 February 2006

Mechanisms of early brain injury after subarachnoid hemorrhage is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.JCBFM.9600283
P698PubMed publication ID16482081
P5875ResearchGate publication ID7295085

P2093author name stringJohn H Zhang
John W Calvert
Julian Cahill
P2860cites workp53 has a direct apoptogenic role at the mitochondriaQ24298888
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondriaQ24311858
BOK and NOXA are essential mediators of p53-dependent apoptosisQ24337595
Caspases: the executioners of apoptosisQ24530218
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2Q24534641
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
Mammalian caspases: structure, activation, substrates, and functions during apoptosisQ28139429
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosisQ28140307
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
Stabilization of wild-type p53 by hypoxia-inducible factor 1alphaQ28267232
The complexity of p53 modulation: emerging patterns from divergent signalsQ28284854
Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signalingQ28304324
Apaf1 is required for mitochondrial pathways of apoptosis and brain developmentQ28505574
Evidence for apoptosis after intercerebral hemorrhage in rat striatumQ28577314
Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neuronsQ28588398
Caspases: enemies withinQ29547315
BCL-2 family members and the mitochondria in apoptosisQ29614427
Cancer. p53, guardian of the genomeQ29615610
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9Q29618617
The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management resultsQ30454281
The International Cooperative Study on the Timing of Aneurysm Surgery. Part 2: Surgical resultsQ30454283
Blood-brain barrier disturbance following subarachnoid hemorrhage in rabbitsQ30456677
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cellsQ31864081
Diffusion MR imaging during acute subarachnoid hemorrhage in ratsQ32012395
Role of p53 family members in apoptosisQ33810088
The Bcl-2 protein familyQ33876776
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES maskingQ33890625
Apoptosis in neural development and diseaseQ33938562
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.Q34011633
Apoptosis signalingQ34019359
An induced proximity model for caspase-8 activation.Q34065853
Subarachnoid haemorrhage: epidemiology, risk factors, and treatment optionsQ34067390
Apoptosis in neurodegenerative disordersQ34186312
Regulation and function of the p53 tumor suppressor proteinQ34245385
The mitochondrion in apoptosis: how Pandora's box opensQ34286386
Hypoxia links ATR and p53 through replication arrestQ34324309
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceQ34408475
Cerebrovascular dysfunction after subarachnoid haemorrhage: novel mechanisms and directions for therapyQ34434692
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.Q34859478
Apoptosis and brain ischaemiaQ35092250
Defects in regulation of apoptosis in caspase-2-deficient miceQ35198808
Psychosocial outcomes at 18 months after good neurological recovery from aneurysmal subarachnoid haemorrhageQ35482635
Role of brain natriuretic peptide in cerebral vasospasmQ35567373
Isolation of p53-target genes and their functional analysisQ35628056
The importance of p53 location: nuclear or cytoplasmic zip code?Q35639326
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activationQ35664020
Relationship between hyperglycemia and symptomatic vasospasm after subarachnoid hemorrhageQ46589088
Role of p38 mitogen-activated protein kinase on cerebral vasospasm after subarachnoid hemorrhageQ47672245
Antivasospastic and brain-protective effects of a hydroxyl radical scavenger (AVS) after experimental subarachnoid hemorrhageQ48021069
Haemodynamic and metabolic disturbances in the acute stage of subarachnoid haemorrhage demonstrated by PET.Q48126864
Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat.Q48144768
The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.Q48261311
Blood-brain barrier damage during the acute stage of subarachnoid hemorrhage, as exemplified by a new animal modelQ48335517
SAH-induced cerebral vasospasm: unraveling molecular mechanisms of a complex diseaseQ48391360
The protective effect of experimental subarachnoid haemorrhage on sodium dehydrocholate-induced blood-brain barrier disruptionQ48393077
Stroke: anatomy of a catastrophic event.Q48459393
Clinical Syndromes in Cerebral Thrombosis, Hypertensive Hemorrhage, and Ruptured Saccular AneurysmQ48484867
Apoptosis and protein expression after focal cerebral ischemia in rat.Q48636604
Ultrastructural changes in the circumventricular organs after experimental subarachnoid hemorrhage.Q48771390
Specific caspase pathways are activated in the two stages of cerebral infarction.Q48798033
Evidence for p53-mediated modulation of neuronal viability.Q48884313
Magnesium and experimental vasospasm.Q48918921
Impact of cerebral microcirculatory changes on cerebral blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage.Q48960075
Intracranial pressure changes following aneurysm rupture. Part 1: clinical and angiographic correlations.Q48987366
Oxyhemoglobin produces apoptosis and necrosis in cultured smooth muscle cells.Q49047579
Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate.Q49077130
Morphological changes of cerebral penetrating arteries in a canine double hemorrhage model.Q49151344
Subarachnoid hemorrhage: epidemiology, diagnosis, management, and outcome.Q49166104
Time-course of blood-brain barrier permeability changes after experimental subarachnoid haemorrhage.Q50510722
The blood-brain barrier following experimental subarachnoid hemorrhage. Part 1: Response to insult caused by arterial hypertension.Q50929861
Barrier disruption in the major cerebral arteries following experimental subarachnoid hemorrhage.Q52496732
The critical first minutes after subarachnoid hemorrhage.Q54126251
Cerebral arterial flow dynamics during aneurysm haemorrhageQ54157386
Mechanisms of apoptosisQ56609201
Cerebral artery spasm. A histological study at necropsy of the blood vessels in cases of subarachnoid hemorrhageQ67296270
Intracranial hypertension in patients with ruptured intracranial aneurysmQ67557050
Value of transcranial Doppler examination in the diagnosis of cerebral vasospasm after subarachnoid hemorrhageQ68143760
Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhageQ70568424
Temporal profile and significance of metabolic failure and trophic changes in the canine cerebral arteries during chronic vasospasm after subarachnoid hemorrhageQ70649237
Cerebral oedema after subarachnoid haemorrhage. Pathogenetic significance of vasopressinQ71370404
Intracranial aneurysmsQ71908767
Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhageQ72041656
Morphological changes of cerebral arteries in a canine double hemorrhage modelQ74268500
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brainQ74284095
Evidence for apoptosis in human intracranial aneurysmsQ74379940
Apoptosis in basilar endothelial cells in a canine double hemorrhage modelQ74528838
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchangeQ74607067
Heat shock protein expression in cerebral vessels after subarachnoid hemorrhageQ74618559
Subarachnoid haemorrhage: what happens to the cerebral arteries?Q77529124
Relationship between intracranial pressure and the development of vasospasm after aneurysmal subarachnoid hemorrhageQ77909060
SACCULAR INTRACRANIAL ANEURYSMS: AN AUTOPSY STUDYQ78343707
Adenosine triphosphate and hemoglobin in vasospastic monkeysQ79975232
MRI of acute brainstem ischaemia: cytotoxic versus vasogenic oedema?Q80348457
Endothelin-1 levels in plasma and cerebrospinal fluid of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhageQ81870720
Cytochrome C-mediated apoptosisQ35799945
Deadly conversations: nuclear-mitochondrial cross-talkQ35891836
HIF-1 and p53: communication of transcription factors under hypoxia.Q35985516
Caspases: potential targets for regulating cell death.Q35985520
The role of p53 in hypoxia-induced apoptosisQ36113108
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell deathQ36325171
Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat.Q36704819
The molecular biology of apoptosisQ37688810
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxiaQ39698671
Cerebral vasospasm following aneurysmal subarachnoid hemorrhageQ39826081
Evolution of early perihemorrhagic changes--ischemia vs. edema: an MRI study in ratsQ40425458
The genetics of programmed cell death in the nematode Caenorhabditis elegans.Q40431225
Mechanisms of cerebral vasospasm in subarachnoid haemorrhage.Q40477995
Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.Q40525549
Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhageQ40626940
Predictors of cognitive dysfunction after subarachnoid hemorrhageQ40667672
Apoptosis of medial smooth muscle cells in the development of saccular cerebral aneurysms in ratsQ40871800
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.Q40960693
Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cellsQ41008844
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosisQ41115305
Prediction of symptomatic vasospasm after subarachnoid hemorrhage by rapidly increasing transcranial Doppler velocity and cerebral blood flow changesQ41117865
Induction of apoptosis in mature T cells by tumour necrosis factorQ41293478
Double identity for proteins of the Bcl-2 familyQ41508318
To die or not to die: an overview of apoptosis and its role in disease.Q41694113
Proteolytic activities that mediate apoptosisQ41748380
The pathogenetic and prognostic significance of blood-brain barrier damage at the acute stage of aneurysmal subarachnoid haemorrhage. Clinical and experimental studiesQ42437100
Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brainQ42484686
Apoptosis of endothelial cells in vessels affected by cerebral vasospasmQ42486897
Intracellular calcium, myosin light chain phosphorylation, and contractile force in experimental cerebral vasospasmQ42519575
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Q42830166
Both caspase-dependent and caspase-independent pathways may be involved in hippocampal CA1 neuronal death because of loss of cytochrome c From mitochondria in a rat forebrain ischemia modelQ43595514
Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcomeQ43629455
Subarachnoid hemorrhage induces dynamic changes in regional cerebral metabolism in ratsQ43979741
Preliminary study of the effects of caspase inhibitors on vasospasm in dog penetrating arteriesQ44077277
Recovering from subarachnoid haemorrhage: patients' perspectiveQ44270347
Subarachnoid hemorrhage-induced upregulation of the 5-HT1B receptor in cerebral arteries in ratsQ44509095
Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhageQ44846933
Effect of acute physiologic derangements on outcome after subarachnoid hemorrhageQ44848532
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alphaQ44897099
Neurovascular protection reduces early brain injury after subarachnoid hemorrhageQ45025356
Signaling pathways for early brain injury after subarachnoid hemorrhageQ45055101
Relationship of local infarctions to cognitive and psychosocial impairments after aneurysmal subarachnoid hemorrhageQ45085987
Multiprofessional follow up of patients after subarachnoid haemorrhageQ45174006
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhageQ45281370
Racial disparities in subarachnoid hemorrhage mortality: Los Angeles County, California, 1985-1998.Q46084006
Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhageQ46509145
P433issue11
P304page(s)1341-1353
P577publication date2006-02-15
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleMechanisms of early brain injury after subarachnoid hemorrhage
P478volume26

Reverse relations

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Q47751688Prognostic Value of Early S100 Calcium Binding Protein B and Neuron-Specific Enolase in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage: A Pilot Study.
Q58591851Prospective Multicenter Study of Changes in MTT after Aneurysmal SAH and Relationship to Delayed Cerebral Ischemia in Patients with Good- and Poor-Grade Admission Status
Q37367617Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia
Q41181418Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy
Q30402587Protective effects of perfluorooctyl-bromide nanoparticles on early brain injuries following subarachnoid hemorrhage in rats.
Q33598845Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats
Q48810795Pseudo-continuous arterial spin labelling MRI for non-invasive, whole-brain, serial quantification of cerebral blood flow following aneurysmal subarachnoid haemorrhage.
Q48496566Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress.
Q49103593Quantification of Cerebral Edema After Subarachnoid Hemorrhage.
Q34429188Rat endovascular perforation model
Q42855751Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin β3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats
Q33903406Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex
Q35762153Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3beta survival signaling
Q36614373Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway
Q33886521Relationship between brain interstitial fluid tumor necrosis factor-α and cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Q47844911Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway
Q82694375Risk factors for three phases of 12-month mortality in 1657 patients from a defined population after acute aneurysmal subarachnoid hemorrhage
Q90245610Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)
Q37094037Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats.
Q46750059Role of autophagy in early brain injury after subarachnoid hemorrhage in rats
Q39760477Role of gap junctions in early brain injury following subarachnoid hemorrhage
Q41830315Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice
Q48369198Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage
Q48912915Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.
Q38169991SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
Q52647371SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
Q37526864SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
Q51291264Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage: News Update.
Q43150582Simultaneous bedside assessment of global cerebral blood flow and effective cerebral perfusion pressure in patients with intracranial hypertension
Q43224448Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage
Q37465847Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats
Q36029059Soluble Toll-Like Receptors 2 and 4 in Cerebrospinal Fluid of Patients with Acute Hydrocephalus following Aneurysmal Subarachnoid Haemorrhage.
Q90721410Sterile Inflammation, Potential Target in Aneurysmal Subarachnoid Hemorrhage
Q90688507Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial
Q89963831Subarachnoid Hemorrhage Induces Dynamic Immune Cell Reactions in the Choroid Plexus
Q64966423Subarachnoid Hemorrhage in Hospitalized Renal Transplant Recipients with Autosomal Dominant Polycystic Kidney Disease: A Nationwide Analysis.
Q38125678Subarachnoid hemorrhage and cerebral vasospasm - literature review
Q37344132Subarachnoid hemorrhage: is it time for a new direction?
Q50791909Systematic model of peripheral inflammation after subarachnoid hemorrhage.
Q104795015TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways
Q37699958Tetramethylpyrazine Protects against Early Brain Injury after Experimental Subarachnoid Hemorrhage by Affecting Mitochondrial-Dependent Caspase-3 Apoptotic Pathway.
Q92347199The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats Are Possibly Mediated by Preventing Blood-Brain Barrier Disruption and RIP3-Mediated Necroptosis
Q52147605The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53.
Q39223884The Role of Autophagy in Subarachnoid Hemorrhage: An Update.
Q92116217The Role of Intracranial Pressure and Subarachnoid Blood Clots in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats
Q48035356The Subarachnoid Hemorrhage Early Brain Edema Score Predicts Delayed Cerebral Ischemia and Clinical Outcomes
Q99414986The Updated Role of the Blood Brain Barrier in Subarachnoid Hemorrhage: From Basic and Clinical Studies
Q37096738The effect of subarachnoid erythrocyte lysate on brain injury: a preliminary study
Q27028040The importance of early brain injury after subarachnoid hemorrhage
Q34356918The myriad essential roles of microRNAs in cardiovascular homeostasis and disease
Q38213375The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage.
Q37479890The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies.
Q40029343The role of arterioles and the microcirculation in the development of vasospasm after aneurysmal SAH.
Q49064990The role of intravenous immunoglobulin in the treatment of cerebral vasospasm induced by subarachnoid haemorrhage: an experimental study.
Q33943701The role of microclot formation in an acute subarachnoid hemorrhage model in the rabbit
Q37365666The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage.
Q33624873Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage
Q33660621Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage
Q64236955Thromboxane-prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats
Q97520923Time Course of Metabolomic Alterations in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage
Q47131419Time-courses of plasma IL-6 and HMGB-1 reflect initial severity of clinical presentation but do not predict poor neurologic outcome following subarachnoid hemorrhage.
Q33747387To look beyond vasospasm in aneurysmal subarachnoid haemorrhage.
Q45981064Topiramate attenuates hippocampal injury after experimental subarachnoid hemorrhage in rabbits.
Q42634950Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats
Q26825343Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage
Q26858772Understanding the role of hemodynamics in the initiation, progression, rupture, and treatment outcome of cerebral aneurysm from medical image-based computational studies
Q55439652Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study.
Q64916851c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats.
Q45285513p53 may play an orchestrating role in apoptotic cell death after experimental subarachnoid hemorrhage
Q39468813α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats

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