Defects in regulation of apoptosis in caspase-2-deficient mice

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Defects in regulation of apoptosis in caspase-2-deficient mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.12.9.1304
P932PMC publication ID316779
P698PubMed publication ID9573047
P5875ResearchGate publication ID51345008

P50authorJodi A FlawsQ63198198
P2093author name stringE Li
A Greenberg
G Macdonald
J Yuan
Y Sun
H Hara
L Bergeron
L Shi
M A Moskowitz
J L Tilly
G I Perez
A Jurisicova
K E Latham
J C Salter
S Varmuza
P2860cites workThe development of facial motoneurones in the mouse--neuronal death and the innervation of the facial musclesQ71147218
Transgenic-mouse model of amyotrophic lateral sclerosisQ72442542
Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cellsQ73101267
Substrate specificities of caspase family proteasesQ73201753
Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodesQ73358709
Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosisQ73520806
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactionsQ24675072
Identification of a set of genes with developmentally down-regulated expression in the mouse brainQ28187594
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeQ28256420
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzymeQ28287610
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32Q28295448
RAIDD is a new 'death' adaptor moleculeQ28300622
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shockQ28307404
Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonadQ28504698
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell deathQ28507741
Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal developmentQ28590612
Activation of caspase-2 in apoptosisQ28611454
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationQ29547561
Caspases: killer proteasesQ29616315
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicityQ34057782
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell deathQ34306496
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzymeQ34325458
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceQ34408475
Axotomy-induced neuronal death during developmentQ35615481
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damageQ36030783
Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factorQ36233580
Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteasesQ36237706
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injuryQ36376859
The genes of cell death and cellular susceptibility to apoptosis in the ovary: a hypothesisQ36390278
RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathwaysQ37303348
Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.Q37306593
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesionsQ37688651
ICE-like proteases in apoptosisQ40443896
Protease activation during apoptosis: death by a thousand cuts?Q40459802
Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosisQ41109952
The cell-death machineQ41110699
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.Q41284156
Inhibition of apoptosis by the expression of antisense Nedd2.Q41326338
Death substrates come aliveQ41516491
Apoptosis and ovarian functionQ41670982
Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawalQ41817127
Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicleQ42479450
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.Q42811228
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.Q48950370
Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach.Q49047301
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.Q54515149
Inhibition of ICE slows ALS in miceQ59081638
Differential Growth of the Mouse Preimplantation Embryo in Chemically Defined Media1Q62555335
P433issue9
P921main subjectapoptotic processQ14599311
P304page(s)1304-1314
P577publication date1998-05-01
P1433published inGenes & DevelopmentQ1524533
P1476titleDefects in regulation of apoptosis in caspase-2-deficient mice
P478volume12

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cites work (P2860)
Q35000544A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity
Q28594295A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells
Q73094515A new savior for neurons
Q33878933A nonapoptotic role for CASP2/caspase 2: modulation of autophagy
Q36324314A novel Apaf-1-independent putative caspase-2 activation complex
Q40482202A novel caspase-2 complex containing TRAF2 and RIP1.
Q47658768A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway
Q33751005A role for retrotransposon LINE-1 in fetal oocyte attrition in mice
Q37146821A tumor suppressor function for caspase-2
Q35409026Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice
Q31948409Activation of the caspase cascade during Stx1-induced apoptosis in Burkitt's lymphoma cells
Q28576773Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum
Q55018023Acute Hepatopancreatic Necrosis Disease (AHPND) related microRNAs in Litopenaeus vannamei infected with AHPND-causing strain of Vibrio parahemolyticus.
Q34463468Ageing and apoptosis
Q35567264Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
Q52564290Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.
Q33944928Altruistic cell suicide and the specialized case of the virus-infected nervous system
Q33307546An intronic signal for alternative splicing in the human genome
Q35679550An unexpected role for caspase-2 in neuroblastoma.
Q44220147Analysis of mutation effects on PIDDosome core complex
Q37663650Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate
Q34469215Apoptosis and brain development.
Q34490937Apoptosis and caspases
Q43764532Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages
Q28507273Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Q35081391Apoptosis in the human ovary
Q36182256Apoptosis in the mammalian CNS: Lessons from animal models.
Q34154044Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Q34395580Apoptosis regulators and their role in tumorigenesis
Q34742803Apoptosis-based therapies
Q34293102Apoptosis-regulating proteins as targets for drug discovery
Q48437297Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons.
Q34753431Apoptotic pathways: the roads to ruin
Q41865581BH3-only protein BIM mediates heat shock-induced apoptosis
Q36463059BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.
Q36322518Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
Q42664386Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.
Q33834241Bone morphogenetic proteins regulate interdigital cell death in the avian embryo.
Q22008618Boo, a novel negative regulator of cell death, interacts with Apaf-1.
Q24522647CARD games in apoptosis and immunity
Q30668600CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
Q40734194Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis
Q30439566Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesis
Q37627556Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Q33705936Caspase 2-mediated tumor suppression involves survivin gene silencing
Q36876621Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression
Q60188540Caspase activation pathways: some recent progress
Q40704833Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Q36643566Caspase function in programmed cell death
Q34336335Caspase functions in cell death and disease
Q35049064Caspase inhibitors as anti-inflammatory and antiapoptotic agents.
Q48908333Caspase mRNA expression in a rat model of focal cerebral ischemia.
Q77508889Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity
Q43594311Caspase-2 activation is redundant during seizure-induced neuronal death
Q44028668Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
Q26863078Caspase-2 as a tumour suppressor
Q40549968Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
Q40753178Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.
Q46467885Caspase-2 cleavage of tau reversibly impairs memory
Q35688389Caspase-2 deficiency enhances aging-related traits in mice
Q28587062Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function
Q36084491Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability
Q35349417Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Q28217828Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
Q50643031Caspase-2 involvement during ionizing radiation-induced oocyte death in the mouse ovary.
Q37527207Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Q24669697Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
Q57274132Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
Q46809696Caspase-2 is required for cell death induced by cytoskeletal disruption
Q35430964Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Q35137731Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts
Q33497936Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus
Q42023225Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis
Q73419649Caspase-2 mediates neuronal cell death induced by beta-amyloid
Q34633549Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3' acceptor site
Q24337211Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
Q92534466Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
Q35091416Caspase-2 redux
Q46227419Caspase-2(L), caspase-9, and caspase-3 during in vitro maturation and fragmentation of the mouse oocyte.
Q34395763Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection
Q28201157Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3
Q41855874Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.
Q24310683Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
Q24595616Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase
Q37954996Caspase-2: the orphan caspase.
Q38216592Caspase-2: the reinvented enzyme
Q36794903Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
Q40621948Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis
Q28678653Caspase-activation pathways in apoptosis and immunity
Q36559701Caspase-containing complexes in the regulation of cell death and inflammation
Q35999742Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury
Q54050681Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis.
Q58199992Caspase-independent death of meiotic and postmeiotic cells overexpressing p53: calpain involvement
Q40655812Caspase-mediated cleavage of the feline calicivirus capsid protein
Q33857511Caspases - controlling intracellular signals by protease zymogen activation
Q37593693Caspases and kinases in a death grip
Q35187214Caspases and neuronal development
Q44196938Caspases are not localized in mitochondria during life or death
Q33598614Caspases as treatment targets in stroke and neurodegenerative diseases
Q37302731Caspases in apoptosis and beyond
Q34652977Caspases in cell survival, proliferation and differentiation.
Q36903477Caspases in myocardial infarction.
Q34733021Caspases on the brain
Q37782134Caspases: evolutionary aspects of their functions in vertebrates.
Q41526704Cell Death in the Developing Brain after Hypoxia-Ischemia
Q35092336Cell stress-associated caspase activation: intrinsically complex?
Q36768874Cell suicide and caspases
Q38111614Cellular mechanisms controlling caspase activation and function
Q24291224Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein
Q30490693Characterization of cytoplasmic caspase-2 activation by induced proximity.
Q36068315Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.
Q28293156Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
Q36796784Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation.
Q48666736Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury.
Q34443613Commuting the death sentence: how oocytes strive to survive
Q52178118Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.
Q33918620Correlation between apoptosis microarray gene expression profiling and histopathological lymph node lesions
Q51913708Coupled positive feedbacks provoke slow induction plus fast switching in apoptosis.
Q27641840Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway
Q35563843DAX1 and its network partners: exploring complexity in development
Q46060882DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
Q28116227DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance
Q35124238DRONC, an ecdysone-inducible Drosophila caspase
Q27643768Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex
Q52583536Death at the Dead Sea.
Q35189419Death from within: apoptosis and the secretory pathway
Q38299296Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.
Q33597385Deciphering the pathways of life and death
Q39309276Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
Q33213493Dendroaspis natriuretic peptide induces the apoptosis of cardiac muscle cells
Q52014452Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation.
Q42707211Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro
Q44095650Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells.
Q41015558Differential requirement for caspase 9 in apoptotic pathways in vivo.
Q57589117Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos
Q34281577Divergent modulation of neuronal differentiation by caspase-2 and -9.
Q33729075Doxorubicin-induced ovarian toxicity
Q34096352Drug discovery opportunities from apoptosis research
Q30865918Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions
Q41948428ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.
Q33840433Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos
Q36092385Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage
Q28472878Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51
Q36124552Epilepsy and apoptosis pathways
Q35964742Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
Q40371421Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
Q36094983Establishment of oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death
Q37191994Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.
Q34146813Executionary pathway for apoptosis: lessons from mutant mice
Q48914845Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos.
Q35122562Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Q27335123Figla-Cre transgenic mice expressing myristoylated EGFP in germ cells provide a model for investigating perinatal oocyte dynamics
Q36674059From primordial germ cell to primordial follicle: mammalian female germ cell development
Q24323139Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage
Q34612835Functional divergence in the caspase gene family and altered functional constraints: statistical analysis and prediction
Q91854086Gametogenesis: A journey from inception to conception
Q34540789Genetic analysis of the mammalian cell death machinery
Q37090126Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice
Q51864092Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.
Q26777164Genetics of the ovarian reserve
Q36461799Germline quality control: eEF2K stands guard to eliminate defective oocytes
Q24603691HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8
Q40207863Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2.
Q50721826Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells.
Q35195215Immune disorders caused by defects in the caspase cascade
Q36193607Immunohistochemical and ultrastructural visualization of different routes of oocyte elimination in adult rats
Q36084482Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice
Q48905837In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos.
Q50744961In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Q35145656In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS.
Q24632632In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates
Q48107418Increased expression of caspase 2 in experimental and human temporal lobe epilepsy
Q92316676Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Q53688952Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Q90366459Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide
Q48892405Injection of sperm cytosolic factor into mouse metaphase II oocytes induces different developmental fates according to the frequency of [Ca(2+)](i) oscillations and oocyte age.
Q64448633Insights into T-Cell Development from Studies Using Transgenic and Knockout Mice
Q33523152Intact fetal ovarian cord formation promotes mouse oocyte survival and development
Q90781282Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development
Q44000528Intracellular calcium oscillations signal apoptosis rather than activation in in vitro aged mouse eggs
Q42023698Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke
Q39052359Involvement of caspase-2 activation in aurora kinase inhibitor-induced cell death in axin-expressing L929 cells
Q36519843Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice
Q42803764Isolation of Ich-1S (caspase-2S)-binding protein that partially inhibits caspase activity
Q34046206Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS.
Q38837351Long and short (timeframe) of endoplasmic reticulum stress-induced cell death
Q37377477Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Q34624467Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons
Q40213057Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization
Q47146168Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa
Q26822688Mammalian foetal ovarian development: consequences for health and disease
Q77918554Markers for hypersensitive response and senescence show distinct patterns of expression
Q39135838Mechanisms controlling germline cyst breakdown and primordial follicle formation
Q56609201Mechanisms of apoptosis
Q36468900Mechanisms of cytochrome c release from mitochondria
Q36398098Mechanisms of early brain injury after subarachnoid hemorrhage
Q36045199Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies
Q27919627Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases
Q38969211Metabolic Regulation of Apoptosis in Cancer.
Q37667099Metabolic activation of CaMKII by coenzyme A.
Q34987200Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2
Q37459556Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
Q36850355Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Q33181924Modulation of apoptosis by procaspase-2 short isoform: selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization
Q50221065Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.
Q33534055Molecular and genetic basis of normal and toxicant-induced apoptosis in female germ cells
Q24290511Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
Q37987945Molecular mechanisms of neonatal brain injury
Q28294027Molecular requirements for doxorubicin-mediated death in murine oocytes
Q34266817Mouse models of cell death
Q44473490Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells.
Q37396889Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant
Q36002031Neuronal caspase 2 activity and function requires RAIDD, but not PIDD
Q37695139Non-caspase proteases: triggers or amplifiers of apoptosis?
Q28140319Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
Q34017721Oocyte attrition
Q37243608Oocyte quality and maternal control of development
Q37419225Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection?
Q24532076Ovarian failure related to eukaryotic initiation factor 2B mutations
Q24805848Ovarian follicle counts--not as simple as 1, 2, 3
Q37977836P53-induced protein with a death domain (PIDD): master of puppets?
Q36223978PIDDosome-independent tumor suppression by Caspase-2.
Q46458121PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
Q40323177PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells
Q38922797Pathophysiology of the Desmo-Adhesome
Q33819236Pertinence of apoptosis markers for the improvement of in vitro fertilization (IVF)
Q93052161Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
Q35222080Physiological functions of caspases beyond cell death
Q36275061Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion
Q34979407Prepubertal primordial follicle loss in mice is not due to classical apoptotic pathways
Q28240178Prevention of chemotherapy-induced ovarian damage: possible roles for hormonal and non-hormonal attenuating agents
Q34166083Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity
Q42826567Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain
Q38207459Programmed cell death during neuronal development: the sympathetic neuron model
Q34831541Programmed cell death in amyotrophic lateral sclerosis
Q42779049Proinflammatory caspase-2-mediated macrophage cell death induced by a rough attenuated Brucella suis strain
Q27437920Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries
Q28593708Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
Q77333515Properties of the caspases
Q33927179Proteases for cell suicide: functions and regulation of caspases
Q48717939Protective effect of a new hypothalamic peptide against cobra venom and trauma-induced neuronal injury.
Q34167263Putative functions of caspase-2.
Q81833471RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal
Q22009930RIP3, a novel apoptosis-inducing kinase
Q29618617Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
Q30365017Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Q33606109Regulation of caspase activation in apoptosis: implications in pathogenesis and treatment of disease
Q100431731Requirement for Serine-384 in Caspase-2 processing and activity
Q40561256Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.
Q37159848Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases
Q37407094Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.
Q33966313Role of TNF in lymphocyte-mediated cytotoxicity
Q44145392Role of apoptosis, apoptosis-related factors and 17beta-hydroxysteroid dehydrogenases in human corpus luteum regression
Q48579081S100A8, An Oocyte-Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly.
Q41882234Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis
Q59393051Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies
Q44985683Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.
Q28289989Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB
Q33793237Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Q34563012Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
Q33547787Signalling by CD95 and TNF receptors: not only life and death.
Q83838476Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2
Q34530525Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility
Q37826107Structural analyses of death domains and their interactions
Q27671643Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis
Q46372868Structural characterization of the mouse high growth deletion and discovery of a novel fusion transcript between suppressor of cytokine signaling-2 (Socs-2) and viral encoded semaphorin receptor (Plexin C1).
Q47873155Structure, expression, and function of the Xenopus laevis caspase family
Q33893107Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.
Q33684353Suicidal tendencies: apoptotic cell death by caspase family proteinases
Q28478529Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells
Q33995667TAF4b promotes mouse primordial follicle assembly and oocyte survival
Q33547792Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.
Q89840958Targeting apoptotic caspases in cancer
Q38626400Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor
Q38704734The DNA damage-induced cell death response: a roadmap to kill cancer cells
Q36932474The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats
Q27003842The PIDDosome, DNA-damage-induced apoptosis and beyond
Q33902384The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria
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