| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/S41418-020-0556-6 |
| P698 | PubMed publication ID | 32415279 |
| P2093 | author name string | Andreas Villunger | |
| Valentina C Sladky | |||
| P2860 | cites work | E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration | Q92951554 |
| Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop | Q24310683 | ||
| The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | Q24336121 | ||
| Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks | Q24626183 | ||
| Caspase-2 activation in the absence of PIDDosome formation | Q24641934 | ||
| Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis | Q24669697 | ||
| Caspase-2 as a tumour suppressor | Q26863078 | ||
| The PIDDosome, DNA-damage-induced apoptosis and beyond | Q27003842 | ||
| New roles for old enzymes: killer caspases as the engine of cell behavior changes | Q27011322 | ||
| Caspase-2 at a glance | Q27025944 | ||
| Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts | Q27312272 | ||
| Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex | Q27643768 | ||
| RAIDD is a new 'death' adaptor molecule | Q28300622 | ||
| Osteoimmunology: interplay between the immune system and bone metabolism | Q28303107 | ||
| BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer | Q28468367 | ||
| Genetic mapping and exome sequencing identify variants associated with five novel diseases | Q28478905 | ||
| DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells | Q28506839 | ||
| Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. | Q28507273 | ||
| Role of prodomain in importin-mediated nuclear localization and activation of caspase-2 | Q28507580 | ||
| E2F8 is essential for polyploidization in mammalian cells | Q28510234 | ||
| Canonical and atypical E2Fs regulate the mammalian endocycle | Q28585165 | ||
| Visualizing spatiotemporal dynamics of multicellular cell-cycle progression | Q29617610 | ||
| Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9 | Q29618617 | ||
| Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis | Q29619888 | ||
| Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. | Q30365017 | ||
| Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease. | Q30474047 | ||
| The genetics of lissencephaly | Q30826834 | ||
| Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiation | Q33433185 | ||
| Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. | Q33586821 | ||
| Caspase 3 activity is required for skeletal muscle differentiation | Q34036654 | ||
| Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress | Q46755641 | ||
| Caspase-2 is required for cell death induced by cytoskeletal disruption | Q46809696 | ||
| Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration | Q47254805 | ||
| The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance | Q47398684 | ||
| Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families | Q47751690 | ||
| Once and only once: mechanisms of centriole duplication and their deregulation in disease. | Q49831825 | ||
| The Polyploid State Plays a Tumor-Suppressive Role in the Liver. | Q50048478 | ||
| In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. | Q50744961 | ||
| Homozygous null variant in CRADD, encoding an adaptor protein that mediates apoptosis, is associated with lissencephaly. | Q52089571 | ||
| Caspase-2 is required for skeletal muscle differentiation and myogenesis. | Q52760464 | ||
| No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice. | Q53286742 | ||
| 14-3-3 protein masks the nuclear localization sequence of caspase-2 | Q57036396 | ||
| RAIDD mutations underlie the pathogenesis of thin lissencephaly (TLIS) | Q57040838 | ||
| Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland | Q61124603 | ||
| Caspase-2 mediates neuronal cell death induced by beta-amyloid | Q73419649 | ||
| RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons | Q75426843 | ||
| Liver tetraploidization is controlled by a new process of incomplete cytokinesis | Q81352210 | ||
| DNA damage- and stress-induced apoptosis occurs independently of PIDD | Q84164825 | ||
| Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis | Q85282900 | ||
| Caspase selective reagents for diagnosing apoptotic mechanisms | Q88634204 | ||
| A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals | Q89983604 | ||
| Cell-Cycle Cross Talk with Caspases and Their Substrates | Q91285741 | ||
| ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P | Q91471145 | ||
| Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells | Q91809334 | ||
| A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients | Q92260918 | ||
| A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease | Q92293460 | ||
| Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling | Q92534466 | ||
| Phenotypic spectrum associated with a CRADD founder variant underlying frontotemporal predominant pachygyria in the Finnish population | Q92637637 | ||
| 14-3-3 protein binding blocks the dimerization interface of caspase-2 | Q92796504 | ||
| Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Tumors Following Chronic Liver Injury | Q92876731 | ||
| Caspases in Cell Death, Inflammation, and Disease | Q92877828 | ||
| PIDD mediates NF-kappaB activation in response to DNA damage | Q34477303 | ||
| Human caspases: activation, specificity, and regulation | Q34608215 | ||
| Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2 | Q34987200 | ||
| Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry. | Q35095612 | ||
| Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts | Q35137731 | ||
| Defects in regulation of apoptosis in caspase-2-deficient mice | Q35198808 | ||
| Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. | Q35430964 | ||
| P21 deficiency delays regeneration of skeletal muscular tissue | Q35571254 | ||
| Caspase-2 deficiency enhances aging-related traits in mice | Q35688389 | ||
| Myoblast fusion: lessons from flies and mice | Q35691569 | ||
| Neuronal caspase 2 activity and function requires RAIDD, but not PIDD | Q36002031 | ||
| Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice | Q36084482 | ||
| Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability | Q36084491 | ||
| Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice | Q36347148 | ||
| The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats | Q36932474 | ||
| IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. | Q37091581 | ||
| Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases | Q37159848 | ||
| Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice | Q37164364 | ||
| Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant | Q37396889 | ||
| Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. | Q37459556 | ||
| Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice | Q37603451 | ||
| The PIDDosome activates p53 in response to supernumerary centrosomes | Q37618954 | ||
| Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? | Q37627556 | ||
| Caspase-2: the orphan caspase. | Q37954996 | ||
| SREBPs: metabolic integrators in physiology and metabolism | Q37966406 | ||
| Physiological significance of polyploidization in mammalian cells | Q38121272 | ||
| Caspase-2: an orphan enzyme out of the shadows | Q38674726 | ||
| PIDD orchestrates translesion DNA synthesis in response to UV irradiation | Q39574364 | ||
| A non-apoptotic role for caspase-9 in muscle differentiation | Q39924087 | ||
| Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2. | Q40361392 | ||
| Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation. | Q41189267 | ||
| ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. | Q41948428 | ||
| ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development | Q42199386 | ||
| Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain | Q42826567 | ||
| Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions | Q42831152 | ||
| NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. | Q44943860 | ||
| A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation | Q46427712 | ||
| Caspase-2 cleavage of tau reversibly impairs memory | Q46467885 | ||
| P577 | publication date | 2020-05-15 | |
| P1433 | published in | Cell Death & Differentiation | Q2943974 |
| P1476 | title | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
| Q104795021 | Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability | cites work | P2860 |
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