The mitochondrial death pathway: a promising therapeutic target in diseases

scientific article published on 9 February 2009

The mitochondrial death pathway: a promising therapeutic target in diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1582-4934.2009.00697.X
P932PMC publication ID4496101
P698PubMed publication ID19220575
P5875ResearchGate publication ID24018662

P50authorEva SzegezdiQ51081339
Bertrand JosephQ92361325
Sanjeev GuptaQ122928855
George E N KassQ122928872
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cellsQ22009395
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition poreQ22011015
PUMA, a novel proapoptotic gene, is induced by p53Q24291463
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell deathQ24291746
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motifQ24291797
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteinsQ24291802
Caspase-10 is an initiator caspase in death receptor signalingQ24291922
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chainQ24295878
Mechanism of XIAP-mediated inhibition of caspase-9Q24296916
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.Q24305298
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloproteaseQ24309083
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell deathQ24312211
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian developmentQ24317252
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53Q24321694
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stressQ24336121
Caspases: the executioners of apoptosisQ24530218
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspasesQ24533214
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helixQ24537504
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystoniaQ24561975
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factorsQ24600405
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2Q24670800
Two distinct pathways leading to nuclear apoptosisQ24676123
Targeted therapy against Bcl-2-related proteins in breast cancer cellsQ25257509
Structural and biochemical basis of apoptotic activation by Smac/DIABLOQ27626899
Structural basis of IAP recognition by Smac/DIABLOQ27629148
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate bindingQ27636119
The genetics of the p53 pathway, apoptosis and cancer therapyQ27863460
A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.Q27936872
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsQ28117866
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients.Q48735298
Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.Q48766874
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.Q48975079
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.Q49054516
Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.Q50519354
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.Q51714635
Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane.Q51766822
A mitochondrial signal peptide from Neurospora crassa increases the permeability of isolated rat liver mitochondria.Q52522858
Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons.Q52538228
Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells.Q53930758
Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.Q53992783
Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines.Q54058131
bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugsQ54261266
Intracellular distribution of a platinum-rhodamine 123 complex in cis-platinum sensitive and resistant human squamous carcinoma cell lines.Q54421868
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.Q55035703
Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria.Q55477217
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition poreQ57082833
Re-examining the role of cytochrome c in cell deathQ57220115
The mitochondrial permeability transition pore may comprise VDAC moleculesQ58022757
Phase II clinical trial of arsenic trioxide with liposomal doxorubicin, vincristine, and dexamethasone in newly diagnosed multiple myelomaQ58049312
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse ModelQ60144092
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosisQ28140307
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosisQ28141949
Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathQ28142036
TRAIL receptor-2 signals apoptosis through FADD and caspase-8Q28142998
Negative regulation of the Apaf-1 apoptosome by Hsp70Q28143100
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosisQ28144256
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interactionQ28199278
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cellsQ28206500
Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membraneQ28208002
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant miceQ28208193
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondriaQ28217828
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosisQ28240946
The ADP/ATP translocator is not essential for the mitochondrial permeability transition poreQ28241418
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deathQ28242641
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell deathQ28242653
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3Q28246420
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseQ28257086
Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1Q28261100
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseasesQ28263484
Mitochondrial disorders in the nervous systemQ28272320
From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance stateQ28280396
Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathwaysQ28289763
Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholineQ28293859
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell deathQ28297152
The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the poreQ28298388
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardiumQ28304462
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Viral control of mitochondrial apoptosisQ28472776
Apaf1 is required for mitochondrial pathways of apoptosis and brain developmentQ28505574
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in miceQ28507648
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosisQ28510508
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissuesQ28512628
Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transitionQ28569445
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathwayQ28581315
Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II studyQ32142109
Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells.Q33178571
Preconditioning protects by inhibiting the mitochondrial permeability transitionQ33201290
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathwayQ33208525
Properties of the permeability transition in VDAC1(-/-) mitochondriaQ33240486
Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cellsQ33340077
Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function.Q33344170
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteinsQ33345150
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancerQ33436217
Cisplatin, epirubicin, and lonidamine combination regimen as first-line chemotherapy for metastatic breast cancer: a pilot study.Q33501807
Generation and characterization of endonuclease G null miceQ33552778
The in-depth evaluation of suspected mitochondrial diseaseQ33608204
Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organismsQ33811822
Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficienciesQ33835849
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.Q33951635
Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cellsQ34124352
The harlequin mouse mutation downregulates apoptosis-inducing factorQ34152182
Generation and characterization of Smac/DIABLO-deficient mice.Q34279589
The mitochondrion in apoptosis: how Pandora's box opensQ34286386
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell deathQ34346499
Reactive oxygen species are downstream mediators of p53-dependent apoptosisQ34403292
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.Q34406704
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxideQ34478428
Development of ligands for the peripheral benzodiazepine receptorQ34547615
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cellsQ34554287
Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondriaQ34555806
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.Q34568313
Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cellsQ34615837
Interaction between cytochrome c and oxidized mitochondrial lipids.Q34661433
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathyQ34670090
Initiator caspases in apoptosis signaling pathwaysQ34724282
Caspases and apoptosisQ35015121
Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heartQ35042002
The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosisQ35071074
Endonuclease G is required for early embryogenesis and normal apoptosis in miceQ28585337
Caspases 3 and 7: key mediators of mitochondrial events of apoptosisQ28588439
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosisQ28589907
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasisQ28592853
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosisQ28594183
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2Q28609079
Mitochondrial Membrane Potential in Living CellsQ29037927
Caspases: enemies withinQ29547315
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
The pathophysiology of mitochondrial cell deathQ29547893
Mitochondrial formation of reactive oxygen speciesQ29547906
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membraneQ29616354
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9Q29618617
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsQ29620467
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.Q30167710
Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brainQ30439574
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.Q30554728
In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitorQ30796097
Targeting the prostate for destruction through a vascular addressQ31037658
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.Q31099877
Kappa- but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in ratsQ31723631
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.Q31929631
Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition poreQ31942254
Preclinical evaluation of antisense bcl-2 as a chemosensitizer for patients with gastric carcinomaQ40505607
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomasQ40529847
Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins.Q40663259
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilizationQ40708852
Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.Q40825681
Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen speciesQ40902510
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.Q40907808
Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell lineQ41000432
Differential requirement for caspase 9 in apoptotic pathways in vivo.Q41015558
Effects of chronic MPTP and 3-nitropropionic acid in nonhuman primatesQ41143014
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.Q41235748
Mitochondrial control of apoptosisQ41339880
The p53-deficient mouse: a model for basic and applied cancer studiesQ41436922
Antisense oligonucleotides as therapeutics for malignant diseases.Q41454086
Sensitization for anticancer drug-induced apoptosis by betulinic AcidQ41468780
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injuryQ41601375
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killerQ41626658
Caspases: intracellular signaling by proteolysisQ41656258
Anti-cancer activity of targeted pro-apoptotic peptidesQ41688099
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.Q41747264
The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible eventQ41837258
Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusionQ41977320
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
Pharmacological manipulation of Bcl-2 family members to control cell deathQ42115619
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.Q42125448
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.Q42264580
Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A.Q42264869
Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in miceQ42484646
bcl-2 protein is increased in the brain from parkinsonian patientsQ42526032
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteinsQ42608652
Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocatorQ42633470
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in miceQ42644118
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.Q42800979
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanismsQ42820922
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.Q43540212
Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicityQ43578822
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.Q43654467
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.Q43711065
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.Q43741513
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotectionQ43794479
Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition poreQ43810158
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.Q43830969
Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.Q43913554
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in miceQ43977943
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosisQ44028668
Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.Q44028946
Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.Q44049211
Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivoQ44122250
Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situQ44129457
Domain-dependent photodamage to Bcl-2. A membrane anchorage region is needed to form the target of phthalocyanine photosensitizationQ44179268
Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondriaQ44201713
All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transitionQ44253646
Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heartQ44401253
Identification of chelerythrine as an inhibitor of BclXL functionQ44408527
N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancersQ44429644
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiformeQ44482659
Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaksQ44593627
Lamellarin D: a novel potent inhibitor of topoisomerase IQ44652190
Heat shock protects PC12 cells against MPP+ toxicityQ44672000
Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injuryQ44917807
Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alphaQ44939694
Mitochondria: releasing power for life and unleashing the machineries of deathQ35071387
Calcium signaling and apoptosisQ35120711
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymeraseQ35615453
Minocycline: neuroprotective mechanisms in Parkinson's diseaseQ35668360
Toxic proteins released from mitochondria in cell deathQ35743127
Bcl-2 and calcium: controversy beneath the surfaceQ35743131
Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogeneQ35884417
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or BakQ35960931
Viral proteins targeting mitochondria: controlling cell deathQ35970213
Death receptor signalingQ36011453
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilizationQ36065778
IAPs, RINGs and ubiquitylationQ36085601
Mitochondrial metabolism of reactive oxygen species.Q36088215
Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells.Q36088627
Killing cancer cells by flipping the Bcl-2/Bax switch.Q36197245
The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosolQ36301514
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic processQ36316624
The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteinsQ36400661
Epsilon protein kinase C as a potential therapeutic target for the ischemic heartQ36458796
Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylationQ36516034
A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.Q36544465
Molecular biology of amyotrophic lateral sclerosis: insights from geneticsQ36573336
Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapyQ36623633
Alzheimer disease: amyloidogenesis, the presenilins and animal models.Q36701553
Neuroprotection in traumatic brain injury: a complex struggle against the biology of natureQ36747114
Channel formation by antiapoptotic protein Bcl-2.Q36765713
The apoptosome: signalling platform of cell deathQ36766418
p53: guardian of the genome and policeman of the oncogenes.Q36800812
Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate familyQ36840801
Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channelsQ36893383
Viral subversion of apoptotic enzymes: escape from death row.Q36925632
The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrixQ36944848
Ischemic preconditioning: from molecular mechanisms to therapeutic opportunitiesQ36999938
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activityQ45007508
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytesQ45091436
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipidsQ45099246
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytesQ45108825
Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III.Q45122067
Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cellsQ45223075
Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expressionQ45264559
DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditionsQ45307545
An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant gliomaQ45858863
Pro-caspase-3 is a major physiologic target of caspase-8.Q46014432
The point of no return: mitochondria, caspases, and the commitment to cell death.Q46018541
The oxidative inactivation of mitochondrial electron transport chain components and ATPase.Q46025170
Ischemic preconditioning: effects on pH, Na and Ca in newborn rabbit hearts during Ischemia/Reperfusion.Q46030121
Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafnessQ46157086
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.Q46355494
Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2.Q46515663
Benzamide protects delayed neuronal death and behavioural impairment in a mouse model of global cerebral ischemiaQ46576688
Disruption of the hexokinase-VDAC complex for tumor therapyQ46602642
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in miceQ46603535
Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transitionQ46604871
A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cellsQ46619108
Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion.Q46642344
IAPs--the ubiquitin connectionQ46645031
Methyl jasmonate binds to and detaches mitochondria-bound hexokinaseQ46647628
The direct physiological effects of mitoK(ATP) opening on heart mitochondria.Q46688354
Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathyQ46762361
Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta.Q46775026
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetesQ46915798
Nicotinamide attenuates retinal ischemia and light insults to neuronesQ46919317
Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membraneQ47807867
PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.Q47935164
Caspases disrupt mitochondrial membrane barrier function.Q48025808
Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodentsQ48091139
Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's diseaseQ48272110
Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemiaQ48307610
Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocyclineQ48386601
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.Q48548442
Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenation.Q48630672
Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress.Q48685006
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damageQ37010881
BCL-2 family proteins: critical checkpoints of apoptotic cell deathQ37038230
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?Q37120213
Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transitionQ37130634
Cytochrome c: functions beyond respirationQ37196132
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatmentsQ37209427
Mitochondrial alterations in Parkinson's disease: new cluesQ37235429
Regulation of hexokinase binding to VDACQ37235994
Update on the pathogenesis of Parkinson's diseaseQ37267302
Bcl-2 inhibitors: small molecules with a big impact on cancer therapyQ37275477
The p53 family and programmed cell deathQ37310208
Metal-catalyzed oxidation of proteins. Physiological consequencesQ37629819
Hexokinase-binding properties of the mitochondrial VDAC protein: inhibition by DCCD and location of putative DCCD-binding sitesQ38208439
Inhibition of adenine nucleotide translocator by lipid peroxidation productsQ38564880
ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosisQ39965483
Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemiasQ39966770
A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.Q40007589
Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.Q40007779
Apoptosis mechanisms related to the increased sensitivity of Jurkat T-cells vs A431 epidermoid cells to photodynamic therapy with the phthalocyanine Pc 4.Q40020538
Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathwayQ40074076
Effects of natural and novel synthetic jasmonates in experimental metastatic melanomaQ40172235
Cooperative cytotoxicity of methyl jasmonate with anti-cancer drugs and 2-deoxy-D-glucoseQ40204588
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleftQ40225582
Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell linesQ40297721
Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.Q40304094
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspasesQ40341729
Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2.Q40355121
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosisQ40365854
Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotectionQ40370821
A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cellsQ40390361
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actionsQ40407735
The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transitionQ40421507
Cyclosporine and liver regeneration studied byin vivo 31P nuclear magnetic resonance spectroscopyQ64004801
Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protectionQ64382269
Histochemical detection of apoptosis in Parkinson's disease.Q67401850
ABT-737, proving to be a great tool even before it is proven in the clinicQ67531174
Protein oxidation and proteolysis during aging and oxidative stressQ69377246
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
Protection in the late stages of paracetamol-induced liver cell injury with fructose, cyslosporin A and trifluoperazineQ71008584
Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: a multicenter randomized clinical trialQ71117003
[Action of the mastoparan from hornet venom on mitochondria]Q71141854
The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous ironQ71701775
Selective toxicity of rhodamine 123 in carcinoma cells in vitroQ71727138
Apoptosis related antigen, Le(Y) and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosisQ72382032
The peptide mastoparan is a potent facilitator of the mitochondrial permeability transitionQ72591996
Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidationQ73101546
Complex I function in familial and sporadic dystoniaQ73282830
Apoptosis in mitochondrial encephalomyopathies with mitochondrial DNA mutations: a potential pathogenic mechanismQ73302183
Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial functionQ73377326
A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077Q73404027
DNA laddering and caspase 3-like activity in the spinal cord of a mouse model of familial amyotrophic lateral sclerosisQ73570352
Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its anti-apoptotic activityQ73574308
Overexpression of bax sensitizes breast cancer MCF-7 cells to cisplatin and etoposideQ73719805
Distinct pathways for stimulation of cytochrome c release by etoposideQ74232909
Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c lossQ74495012
Peptides derived from BH3 domains of Bcl-2 family members: a comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell deathQ74504191
MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude miceQ74619562
The central executioners of apoptosis: caspases or mitochondria?Q77135310
Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome cQ77531504
Apoptosis: cell death defined by caspase activationQ77921203
ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondriaQ78157357
Pretreatment with the cyclosporin derivative, NIM811, improves the function of synaptic mitochondria following spinal cord contusion in ratsQ80170100
Mitochondria and neurodegenerationQ80184491
Membrane-insertion fragments of Bcl-xL, Bax, and BidQ80478793
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1Q81160686
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platformQ81446314
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
signal transductionQ828130
apoptotic processQ14599311
mitochondrial membrane potentialQ70709058
P304page(s)1004-1033
P577publication date2009-02-09
2009-06-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleThe mitochondrial death pathway: a promising therapeutic target in diseases
P478volume13

Reverse relations

cites work (P2860)
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