Autophagy: dual roles in life and death?

scientific article

Autophagy: dual roles in life and death? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1038/NRM1666
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/nrm1666
P698PubMed publication ID15928714
P5875ResearchGate publication ID7812832

P2093author name stringEric H Baehrecke
P2860cites workThe Hallmarks of CancerQ221226
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting proteinQ22003920
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector moleculeQ24290576
HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell deathQ24305591
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian developmentQ24317252
Inhibition of macroautophagy triggers apoptosisQ24338482
Autophagy in the eukaryotic cellQ24532252
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationQ24535862
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorQ24569647
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneQ24617547
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell deathQ24673427
Tor-mediated induction of autophagy via an Apg1 protein kinase complexQ24685670
Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualizationQ24800775
The phosphoinositide 3-kinase pathwayQ27860738
Mechanisms of caspase activation and inhibition during apoptosisQ27919623
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiaeQ27935838
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiencyQ28204372
Molecular dissection of autophagy: two ubiquitin-like systemsQ28206420
Size control in animal developmentQ28297142
Apaf1 is required for mitochondrial pathways of apoptosis and brain developmentQ28505574
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosisQ28509136
Development by self-digestion: molecular mechanisms and biological functions of autophagyQ29547880
Autophagy as a regulated pathway of cellular degradationQ29547914
Autophagy genes are essential for dauer development and life-span extension in C. elegansQ29614180
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cellsQ29614181
Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathwayQ29614186
Role and regulation of starvation-induced autophagy in the Drosophila fat bodyQ29617035
Isolation of autophagocytosis mutants of Saccharomyces cerevisiaeQ29617037
Autophagy in health and disease: a double-edged swordQ29618103
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9Q29618617
A Unified Nomenclature for Yeast Autophagy-Related GenesQ29618950
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8Q29620200
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genesQ29620366
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathwayQ31105211
Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogasterQ33968343
Four deaths and a funeral: from caspases to alternative mechanisms.Q34325335
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceQ34408475
Deadly encounter: ubiquitin meets apoptosisQ34522855
How death shapes life during developmentQ34931816
Autophagy: a barrier or an adaptive response to cancer.Q35078446
Caspase-independent cell death in T lymphocytesQ35116688
PI3K/Akt and apoptosis: size mattersQ35603373
The molecular machinery of autophagy: unanswered questionsQ35690097
Caspase-independent cell killing by Fas-associated protein with death domainQ36256374
Necrotic death pathway in Fas receptor signalingQ36360371
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitroQ37073511
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formationQ37369188
Developmental cell death: morphological diversity and multiple mechanismsQ37922145
Steroid regulation of midgut cell death during Drosophila developmentQ40631448
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathwayQ40789651
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathwaysQ42972664
The morphology of various types of cell death in prenatal tissuesQ44016309
Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiaeQ44755200
Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in DrosophilaQ47071601
Caspases function in autophagic programmed cell death in DrosophilaQ47071730
Programmed cell death of developing mammalian neurons after genetic deletion of caspases.Q48829797
Interdigital cell death can occur through a necrotic and caspase-independent pathway.Q52174168
Cell biology: regulated self-cannibalism.Q52650762
Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila.Q53658652
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.Q53956406
A matter of life and deathQ63408384
Autophagy in human tumors: cell survival or death?Q80088161
P433issue6
P921main subjectautophagyQ288322
P304page(s)505-510
P577publication date2005-06-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleAutophagy: dual roles in life and death?
P478volume6

Reverse relations

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Q41697355Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells.
Q35108580Intertwined pathways of programmed cell death in immunity
Q47983763Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic and Regenerative Pathways in the Mouse Brain
Q92344421Investigation of ATG16L1 rs2241880 Polymorphism with Cancer Risk: A Meta-Analysis
Q54566322Investigation of Association between Autophagy-Related Gene Polymorphisms and Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in a Spanish Population.
Q34787032Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation
Q39680489Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
Q37587232Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction
Q81153971Isolation of mitochondria from embryogenic cultures of Picea abies (L.) Karst. and Abies cephalonica Loud.: characterization of a K+(ATP) channel
Q35026243Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells
Q36388437LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy
Q33816450LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas
Q36557149Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells
Q53237937Life or death: disease-tolerant coral species activate autophagy following immune challenge.
Q34096338Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease
Q34979855Liver function test abnormalities in anorexia nervosa--cause or effect
Q100696512LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy
Q34165710Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells
Q41509350Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis
Q24298248Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation
Q34388808MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation.
Q35103104Macroautophagy: the key ingredient to a healthy diet?
Q34498303Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
Q61818162Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells
Q30446389Matrix Metalloproteinase Inhibition Mitigates Renovascular Remodeling in Salt-Sensitive Hypertension
Q38266793Mechanisms and biological functions of autophagy in diseased and ageing kidneys.
Q55061705Mechanisms of tolvaptan-induced toxicity in HepG2 cells.
Q55545369Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.
Q37043326Membrane trafficking in neuronal maintenance and degeneration.
Q37465911Methamphetamine potentiates HIV-1 gp120-mediated autophagy via Beclin-1 and Atg5/7 as a pro-survival response in astrocytes
Q34070445Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth
Q38963722Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
Q88030471MiR-124 induces autophagy-related cell death in cholangiocarcinoma cells through direct targeting of the EZH2-STAT3 signaling axis
Q33635345Mir30c Is Involved in Diabetic Cardiomyopathy through Regulation of Cardiac Autophagy via BECN1
Q37278020Mitochondria and reactive oxygen species.
Q26771761Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury
Q21195362Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
Q39435332Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy
Q37800527Mitochondrial involvement in cell death of non-mammalian eukaryotes
Q95267269Mitofusin1 Is a Major Mediator in Glucose-Induced Epithelial-to-Mesenchymal Transition in Lung Adenocarcinoma Cells
Q37639334Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges
Q33288114Molecular determinants of caste differentiation in the highly eusocial honeybee Apis mellifera
Q34328149Myocardial autophagy after severe burn in rats
Q97419120Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells
Q38837591Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences.
Q46090818Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi.
Q39196767Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma
Q42223195Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.
Q36855769Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
Q39065633Nexrutine inhibits survival and induces G1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line
Q64272978Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease
Q37295450On the role of autophagy in human diseases: a gender perspective
Q38033591Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets
Q48505113Ophiopogonin B sensitizes TRAIL-induced apoptosis through activation of autophagy flux and downregulates cellular FLICE-like inhibitory protein.
Q36642839Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway
Q34320998Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells
Q34721597Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis
Q29038178Overexpression of Atg5 in mice activates autophagy and extends lifespan
Q42678605Overexpression of DRAM enhances p53-dependent apoptosis
Q40071790Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
Q36729017Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells
Q37656960PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.
Q37382416PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries
Q39484780Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90.
Q47162304Phospholamban Is Downregulated by pVHL-Mediated Degradation through Oxidative Stress in Failing Heart
Q37409477Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors.
Q46271334Pitavastatin attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes
Q51703244Plasminogen activator inhibitor-1 regulates LPS induced inflammation in rat macrophages through autophagy activation.
Q35903425Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
Q47139658PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy
Q42435408Premature aging in mice activates a systemic metabolic response involving autophagy induction.
Q38695643Procyanidins from Vitis vinifera seeds induce apoptotic and autophagic cell death via generation of reactive oxygen species in squamous cell carcinoma cells
Q33767555Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.
Q33598931Proteasome inhibitors in glioblastoma
Q35689588Protective Macroautophagy Is Involved in Vitamin E Succinate Effects on Human Gastric Carcinoma Cell Line SGC-7901 by Inhibiting mTOR Axis Phosphorylation
Q92582045Protective effects of salvianolic acid B against hydrogen peroxide‑induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms
Q35040337Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury
Q54468428Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.
Q52676250Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development.
Q46646925Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
Q38714234Quercetin simultaneously induces G0 /G1 -phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells
Q50229635Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.
Q38778135RACK1 depletion in the ribosome induces selective translation for non-canonical autophagy
Q34068120RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT.
Q36079998ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
Q33926261Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor.
Q53048992Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice.
Q28115279Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1
Q28387919Recent progress in research on molecular mechanisms of autophagy in the heart
Q34373116Reciprocal regulation of autophagy and dNTP pools in human cancer cells
Q38015801Regulation and function of autophagy during cell survival and cell death.
Q38613277Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0).
Q34995420Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.
Q34484983Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
Q37694356Regulation of autophagy in mammals and its interplay with apoptosis.
Q36873616Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy
Q88937391Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells
Q37641525Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells
Q41820521Reticulophagy and ribophagy: regulated degradation of protein production factories.
Q28486246Retracted: The Interplays between Autophagy and Apoptosis Induced by Enterovirus 71
Q41609951Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling
Q35161917Role and regulation of autophagy in cancer
Q39335880Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
Q39810072Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
Q33965396Role of autophagy and apoptosis in wound tissue of deep second-degree burn in rats
Q47117635Role of autophagy and its signaling pathways in ischemia/reperfusion injury
Q33808483Role of autophagy in breast cancer
Q29620348Role of autophagy in cancer
Q37728936Role of autophagy in heart failure associated with aging
Q50422237Role of autophagy in modulating post-maturation aging of mouse oocytes.
Q45354950Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells
Q34576155Roles of autophagy in cetuximab-mediated cancer therapy against EGFR.
Q39580970Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells
Q37556841Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms.
Q36096714SD118-xanthocillin X (1), a novel marine agent extracted from Penicillium commune, induces autophagy through the inhibition of the MEK/ERK pathway.
Q98906663SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells
Q37295795STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy
Q38832393SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells
Q39326032Salmonella enterica serovar Typhi plasmid pR ST98 enhances intracellular bacterial growth and S. typhi-induced macrophage cell death by suppressing autophagy
Q29617748Self-eating and self-killing: crosstalk between autophagy and apoptosis
Q34515814Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus
Q34399078Severe starvation-induced hepatocyte autophagy as a cause of acute liver injury in anorexia nervosa: a case report
Q53685617Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy.
Q90090983Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7
Q35893093Silvestrol induces early autophagy and apoptosis in human melanoma cells
Q48132206Starvation triggers Abeta42 generation from human umbilical vascular endothelial cells
Q38693407Stress management by autophagy: Implications for chemoresistance
Q37803277Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes
Q37971760Suppression of autophagy by BCR/ABL.
Q101149100Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR-22-3p
Q38833593Survival and death of endoplasmic-reticulum-stressed cells: Role of autophagy
Q38859942Synergistic anticancer effects of combined γ-tocotrienol and oridonin treatment is associated with the induction of autophagy.
Q39446764Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
Q33452941Systematic cloning and analysis of autophagy-related genes from the silkworm Bombyx mori
Q37187513TERT alleviates irradiation-induced late rectal injury by reducing hypoxia-induced ROS levels through the activation of NF-κB and autophagy
Q89237323TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis
Q37170788Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
Q36326247Targeting cancer by binding iron: Dissecting cellular signaling pathways
Q26749391Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy
Q35652905The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway
Q40768333The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury.
Q92619576The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases
Q57281949The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation
Q57842531The Basics of Autophagy
Q39043141The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB.
Q37492634The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells.
Q42509261The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
Q24618100The PEA-15 protein regulates autophagy via activation of JNK
Q57479880The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death
Q36518216The Retinoblastoma Tumor Suppressor Protein (pRb)/E2 Promoter Binding Factor 1 (E2F1) Pathway as a Novel Mediator of TGFβ-induced Autophagy
Q38025378The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi.
Q39149568The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells
Q36612361The archaeology of apoptosis
Q44008924The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium
Q37196064The cell biology of autophagy in metazoans: a developing story
Q46593310The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy
Q35819635The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells
Q38034271The contribution of autophagy to lymphocyte survival and homeostasis
Q39949652The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis.
Q36396884The dynamic role of autophagy and MAPK signaling in determining cell fate under cisplatin stress in osteosarcoma cells.
Q34103230The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex
Q43156856The flavonoid luteolin enhances doxorubicin-induced autophagy in human osteosarcoma U2OS cells
Q41517688The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila.
Q40044863The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy
Q46570598The level of free intracellular zinc mediates programmed cell death/cell survival decisions in plant embryos
Q38254507The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders.
Q37073671The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells
Q38584313The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer.
Q36734187The pro-social neurohormone oxytocin reverses the actions of the stress hormone cortisol in human ovarian carcinoma cells in vitro
Q37824183The regulation of autophagy - unanswered questions
Q28506886The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Q37228041The role of autophagy in lung ischemia/reperfusion injury after lung transplantation in rats
Q41920599The role of autophagy in usnic acid-induced toxicity in hepatic cells.
Q37054679The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
Q38164901The role of ubiquitin ligases in cardiac disease.
Q35028378Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis
Q36068290Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy
Q41809321To die or not to die--a role for Fork head
Q40088057Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death
Q42025723Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues
Q59355189Tumor microenvironment mediated by suppression of autophagic flux drives liver malignancy
Q36116239Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells
Q34775357Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential
Q96950740ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins
Q35122866ULK1: a promising biomarker in predicting poor prognosis and therapeutic response in human nasopharygeal carcinoma
Q42584848Uba1 functions in Atg7- and Atg3-independent autophagy
Q92374399Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-κB axis
Q38833614Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection - Future Perspectives.
Q58588286Upregulation of AMPK by 4-O-methylascochlorin promotes autophagy via the HIF-1α expression
Q28573294Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
Q51584417Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process.
Q37736044Viral interactions with macroautophagy: a double-edged sword
Q37211971WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma
Q35884610Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
Q55657568Wheat Gene TaATG8j Contributes to Stripe Rust Resistance.
Q36739979XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells
Q34795766YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells
Q36070278miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells
Q40170381p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
Q38039369α-Synuclein and neuronal cell death
Q38769519βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells

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