| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.8372353 |
| P698 | PubMed publication ID | 8372353 |
| P2093 | author name string | K. Nakayama | |
| F. W. Alt | |||
| I. Negishi | |||
| K. Kuida | |||
| L. E. Fields | |||
| M. C. Louie | |||
| P. J. Lucas | |||
| V. Stewart | |||
| Y. Shinkai | |||
| P2860 | cites work | Bcl-2 maintains B cell memory | Q24308796 |
| Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation | Q34559025 | ||
| P433 | issue | 5128 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | B cell leukemia/lymphoma 2 | Q14863583 |
| homozygosity | Q114049690 | ||
| P304 | page(s) | 1584–1588 | |
| P577 | publication date | 1993-09-17 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice | |
| P478 | volume | 261 |
| Q24673150 | A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death |
| Q58581736 | A1/Bfl-1 expression is restricted to TCR engagement in T lymphocytes |
| Q28507011 | Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice |
| Q31949951 | Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice |
| Q42155614 | Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. |
| Q74062926 | Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse |
| Q41090386 | Analysis of gene function in lymphocytes by RAG-2-deficient blastocyst complementation. |
| Q42063420 | Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts |
| Q31961983 | Antisense inhibition of BCL-2 expression induces retinoic acid-mediated cell death during differentiation of human NT2N neurons |
| Q28586419 | Apoptosis and Bcl-2 expression in cultured murine splenic T cells |
| Q37815428 | Apoptosis and autophagy in the regulation of T lymphocyte function |
| Q41290168 | Apoptosis and gastrointestinal pharmacology. |
| Q34617122 | Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells |
| Q28508919 | Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice |
| Q40551607 | Apoptosis in viral infections |
| Q77768076 | Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer |
| Q37356313 | Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2 |
| Q41064231 | Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression |
| Q71517555 | Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus |
| Q41515231 | Apoptosis: an overview of the process and its relevance in disease. |
| Q33811739 | Apotosis of mature B cells |
| Q36368953 | Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response |
| Q40460122 | B Cell Activation and Apoptosis |
| Q41531174 | B cell development in mice |
| Q31915818 | BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis |
| Q46508943 | BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs |
| Q37689611 | Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires |
| Q28588586 | Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice |
| Q41229247 | Bax-independent inhibition of apoptosis by Bcl-XL. |
| Q28506869 | Bcl-2 accelerates the maturation of early sensory neurons |
| Q36689609 | Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation |
| Q41345463 | Bcl-2 and the ICE family of apoptotic regulators: making a connection. |
| Q35869104 | Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival |
| Q36581944 | Bcl-2 family members and apoptosis, taken to heart |
| Q33699417 | Bcl-2 gene family and related proteins in mammary gland involution and breast cancer |
| Q52055673 | Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. |
| Q48594618 | Bcl-2 influences axonal growth rate in embryonic sensory neurons. |
| Q24315654 | Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development |
| Q38735628 | Bcl-2 proteins in development, health, and disease of the hematopoietic system. |
| Q36365670 | Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice |
| Q41522438 | Bcl-x and the regulation of survival in the immune system. |
| Q38360398 | Bcl-x(S) anatagonizes the protective effects of Bcl-x(L). |
| Q34261390 | Bclx regulates the survival of double-positive thymocytes |
| Q28589263 | Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis |
| Q40789595 | CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis |
| Q41493220 | CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes. |
| Q34082790 | Cell death control in lymphocytes. |
| Q41180587 | Cellular and molecular analysis of lymphoid development using Rag-deficient mice |
| Q48354251 | Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. |
| Q39804055 | Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo |
| Q36079003 | Comparison of predicted and actual consequences of missense mutations |
| Q37179317 | Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival. |
| Q28507853 | Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells |
| Q36366830 | Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloantigens |
| Q34009660 | Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? |
| Q34390190 | Control of Bcl-2 expression by reactive oxygen species |
| Q39191694 | Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes |
| Q28589698 | Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo |
| Q43761483 | Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase. |
| Q40460111 | Death Genes in T Cells |
| Q36073436 | Decision checkpoints in the thymus |
| Q30193575 | Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. |
| Q28590902 | Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes |
| Q52113818 | Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. |
| Q52190945 | Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. |
| Q28585556 | Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations |
| Q40063265 | Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis. |
| Q71170504 | Differential requirements for alpha4 integrins during fetal and adult hematopoiesis |
| Q48020712 | Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death |
| Q41289583 | Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations |
| Q39277476 | Dying to protect: cell death and the control of T-cell homeostasis. |
| Q34630749 | Dysregulation of apoptosis and a novel mechanism of defective apoptotic signal transduction in human B-cell neoplasms |
| Q24561811 | Early embryonic death in mice lacking the beta-catenin-binding protein Duplin |
| Q73304605 | Effects of glucocorticoids on rat thymus and apoptosis |
| Q83289839 | Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis |
| Q35608164 | Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice |
| Q35828796 | Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma |
| Q36380837 | Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells |
| Q44746555 | Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL. |
| Q35609732 | Expression of Bcl-2 in inflammatory sites from patients with active Behçet's disease |
| Q38457345 | Expression of bcl-2 protein in active skin lesions of Behçet's disease |
| Q71011992 | Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli |
| Q52202641 | Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. |
| Q40913568 | Functional aspects of apoptosis in hematopoiesis and consequences of failure |
| Q36557341 | Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis |
| Q52020873 | Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation. |
| Q36201676 | Genes, pathways and checkpoints in lymphocyte development and homeostasis. |
| Q41515240 | Genetics of apoptosis |
| Q38092837 | Getting away with murder: how does the BCL-2 family of proteins kill with immunity? |
| Q36628641 | Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes |
| Q73294571 | Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients |
| Q36267187 | Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice |
| Q42943984 | Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily |
| Q28201501 | Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis |
| Q37360475 | Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli |
| Q40024215 | Kinase cascades regulating entry into apoptosis |
| Q61714693 | Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts |
| Q38307680 | Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy |
| Q33822567 | Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice |
| Q49636303 | Life and Death of Activated T Cells: How Are They Different from Naïve T Cells? |
| Q35748002 | Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. |
| Q73604873 | Lupus nephritis |
| Q40460153 | Maintenance of the T Lymphocyte Pool by Inhibition of Apoptosis: A Novel Strategy of Immunostimulation? |
| Q41772001 | Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses |
| Q33838448 | Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. |
| Q34467084 | Mechanism of BLyS action in B cell immunity. |
| Q37341018 | Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis |
| Q29616203 | Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors |
| Q24610279 | MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts |
| Q52194046 | Modulation of cell death in yeast by the Bcl-2 family of proteins. |
| Q41722123 | Molecular and cellular mechanisms of T lymphocyte apoptosis |
| Q38953543 | Molecular pathways driving disease-specific alterations of intestinal epithelial cells |
| Q40585555 | More to learn from gene knockouts |
| Q40992098 | Multiple control elements are required for expression of the human CD34 gene. |
| Q57200230 | Mutational analysis in 119 families with nephronophthisis |
| Q41284955 | Negative signaling in B cells by surface immunoglobulins |
| Q74261411 | Overexpression of bcl-2 alters usage of mutational hot spots in germinal center B cells |
| Q28594083 | PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors |
| Q30710689 | Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? |
| Q41922560 | Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules |
| Q57939597 | Programmed cell death in Caenorhabditis elegans |
| Q36473581 | Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice |
| Q43800522 | Protection of T cells from radiation-induced apoptosis by Cepharanthin |
| Q40812418 | Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance |
| Q29618617 | Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9 |
| Q35014068 | Regulation of B-cell fate by antigen-receptor signals |
| Q24310154 | Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse |
| Q42947038 | Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice |
| Q41290962 | Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis. |
| Q72238613 | Rescue of ileal Peyer's patch B cells from apoptosis is associated with the induction of Bcl-2 expression |
| Q24307948 | Role of BCL-2 in the survival and function of developing and mature sympathetic neurons |
| Q34733047 | Role of Bcl-2 family of proteins in malignancy |
| Q38754935 | Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD). |
| Q33955146 | Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury |
| Q46988935 | Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2. |
| Q41399533 | Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts |
| Q40373293 | Self-tolerance checkpoints in B lymphocyte development |
| Q33793237 | Signaling of neuronal cell death by the p75NTR neurotrophin receptor |
| Q52053087 | Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. |
| Q41228748 | Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/-Bcl-xLTg mice |
| Q36404247 | Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes |
| Q57719083 | Survival-independent function of NF-κB⧹Rel during late stages of thymocyte differentiation |
| Q36365766 | T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice |
| Q38780078 | Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. |
| Q28591736 | Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia |
| Q28507216 | Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication |
| Q53819035 | Targeting BCL-2 regulated apoptosis in cancer. |
| Q37634558 | Targeting the BCL-2 family in malignancies of germinal centre origin. |
| Q38193997 | Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? |
| Q40372954 | The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection. |
| Q24620437 | The Bcl-2 apoptotic switch in cancer development and therapy |
| Q35591695 | The Bcl-2 family: roles in cell survival and oncogenesis. |
| Q35031256 | The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions |
| Q36216308 | The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses. |
| Q36362663 | The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus |
| Q42091535 | The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages |
| Q36303128 | The antisense bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides |
| Q24310135 | The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression |
| Q35647500 | The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. |
| Q33657947 | The chosen few? Positive selection and the generation of naive B lymphocytes |
| Q28512628 | The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues |
| Q43694144 | The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells |
| Q28508171 | The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression |
| Q35083049 | The essential role of evasion from cell death in cancer |
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| Q24317954 | The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2 |
| Q24323137 | The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M |
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