Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice

scientific article published on 12 October 2011

Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-07-367672
P932PMC publication ID3236120
P698PubMed publication ID21998213
P5875ResearchGate publication ID51716168

P50authorJerry AdamsQ6183179
Andreas StrasserQ38803763
P2093author name stringPriscilla N Kelly
Alex R D Delbridge
Stephanie Grabow
P2860cites workThe Hallmarks of CancerQ221226
Bim is a suppressor of Myc-induced mouse B cell leukemiaQ37647369
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesQ37921609
Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosisQ38798819
A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1.Q39574938
Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.Q40479135
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesisQ41860419
Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc.Q47579113
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypesQ53398443
E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.Q53483651
The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic miceQ57338720
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceQ57338722
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)Q59085244
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient miceQ72600081
Antiapoptotic BCL-2 is required for maintenance of a model leukemiaQ80591496
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
Suppression of tumorigenesis by the p53 target PUMAQ24563144
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxaQ28204059
Puma is an essential mediator of p53-dependent and -independent apoptotic pathwaysQ28213279
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytesQ28510299
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissuesQ28512628
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairQ28586758
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric miceQ28593186
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
The landscape of somatic copy-number alteration across human cancersQ29547648
Induction of apoptosis in fibroblasts by c-myc proteinQ29614346
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitorQ29616727
Mechanisms promoting translocations in editing and switching peripheral B cellsQ34008189
BH3-Only proteins-essential initiators of apoptotic cell deathQ34117362
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocationQ34245495
Apoptotic cell death induced by c-myc is inhibited by bcl-2.Q34255589
Cooperative interaction between c-myc and bcl-2 proto-oncogenesQ34255596
Mcl-1 is essential for germinal center formation and B cell memoryQ34348204
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistanceQ34369809
Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphomaQ35828796
Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survivalQ35904282
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutantsQ36142180
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cellsQ36354457
bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.Q36366215
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesisQ36846076
Diagnosing and exploiting cancer's addiction to blocks in apoptosisQ37059647
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteinsQ37309119
The ups and downs of Myc biologyQ37644952
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)6380-6386
P577publication date2011-10-12
P1433published inBloodQ885070
P1476titleEndogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice
P478volume118

Reverse relations

cites work (P2860)
Q34259242A two-way street: reciprocal regulation of metabolism and signalling.
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Q42177793BCL-W has a fundamental role in B cell survival and lymphomagenesis
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Q56335042Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer
Q64054212IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis
Q57068289Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression
Q36349985Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)
Q38742807MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Q57036262MYC-driven malignant transformation of mature murine B cells requires inhibition of both intrinsic apoptosis and p53 activity
Q37542446Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis
Q36473581Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice
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Q36762189Targeting MYC in cancer therapy: RNA processing offers new opportunities
Q90047057Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer
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Q37594415Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eμ-myc lymphoma

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