| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1085710965 |
| P356 | DOI | 10.1007/S00441-017-2628-6 |
| P698 | PubMed publication ID | 28560694 |
| P2093 | author name string | Christoph Borner | |
| Lukas Peintner | |||
| P2860 | cites work | Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions | Q39135386 |
| Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys | Q39650947 | ||
| Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress | Q39890975 | ||
| The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells | Q40387264 | ||
| Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells | Q40838856 | ||
| The polycystic kidney disease 1 gene product modulates Wnt signaling | Q40973635 | ||
| Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila | Q41913649 | ||
| Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. | Q42015539 | ||
| Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels | Q42048727 | ||
| Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation | Q42056408 | ||
| Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo | Q42549374 | ||
| Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. | Q42601106 | ||
| Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. | Q42835093 | ||
| The Roles of Primary cilia in Polycystic Kidney Disease | Q43108582 | ||
| Expression, purification and use of recombinant annexin V for the detection of apoptotic cells | Q43281026 | ||
| Akt enhances Mdm2-mediated ubiquitination and degradation of p53. | Q43940083 | ||
| To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. | Q46142204 | ||
| Autophagy in long propriospinal neurons is activated after spinal cord injury in adult rats. | Q48461177 | ||
| Polycystin expression during embryonic development of human kidney in adult tissues and ADPKD tissue | Q48534818 | ||
| Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. | Q52575181 | ||
| Mitotic catastrophe: a mechanism for avoiding genomic instability. | Q52610466 | ||
| Calcium orchestrates apoptosis. | Q54055382 | ||
| Autosomal dominant polycystic kidney disease | Q55898854 | ||
| Polycystin-2 is an intracellular calcium release channel | Q24292332 | ||
| Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development | Q24292456 | ||
| Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain | Q24295878 | ||
| Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2 | Q24297056 | ||
| Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization | Q24300125 | ||
| Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals | Q24300420 | ||
| Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase | Q24302381 | ||
| Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. | Q24336734 | ||
| mTOR is a key modulator of ageing and age-related disease | Q24610741 | ||
| Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword | Q26774029 | ||
| Anoikis molecular pathways and its role in cancer progression | Q26852158 | ||
| Role of apoptosis in disease | Q26865637 | ||
| Autophagy in the Pathogenesis of Disease | Q27860558 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease | Q28075652 | ||
| Loss of autophagy in the central nervous system causes neurodegeneration in mice | Q28131804 | ||
| Cell death by mitotic catastrophe: a molecular definition | Q28255830 | ||
| Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis | Q28292299 | ||
| Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene | Q28507278 | ||
| Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms | Q28511640 | ||
| PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 | Q28585618 | ||
| Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair | Q28586758 | ||
| Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim | Q28587387 | ||
| Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta | Q28591284 | ||
| Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice | Q28593186 | ||
| Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin | Q28748484 | ||
| Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer | Q29248711 | ||
| Induction of apoptosis in fibroblasts by c-myc protein | Q29614346 | ||
| Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury | Q29616008 | ||
| Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion | Q30480137 | ||
| Apoptosis and loss of renal tissue in polycystic kidney diseases | Q36707140 | ||
| Primary cilia are not calcium-responsive mechanosensors | Q36852774 | ||
| Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death | Q36997814 | ||
| Regulation of cell polarity during epithelial morphogenesis | Q37087765 | ||
| Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. | Q37092766 | ||
| Measuring apoptosis at the single cell level | Q37099915 | ||
| TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum | Q37133158 | ||
| Anoikis: a necessary death program for anchorage-dependent cells | Q37245449 | ||
| Loss of polycystin-1 causes centrosome amplification and genomic instability | Q37294781 | ||
| Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts | Q37340219 | ||
| Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt | Q37399825 | ||
| Apoptosis in polycystic kidney disease. | Q37829502 | ||
| The 'complexities' of life and death: death receptor signalling platforms | Q38006283 | ||
| Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release | Q38094830 | ||
| Strategies targeting cAMP signaling in the treatment of polycystic kidney disease | Q38171193 | ||
| Measuring caspase activity in vivo | Q38224134 | ||
| Translational research in ADPKD: lessons from animal models | Q38241290 | ||
| Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling | Q38289224 | ||
| Necroptosis and its role in inflammation | Q38319916 | ||
| Identification and characterization of polycystin-2, the PKD2 gene product | Q38320261 | ||
| Promises and Challenges of Smac Mimetics as Cancer Therapeutics | Q38633124 | ||
| Cell death induced by endoplasmic reticulum stress. | Q38639996 | ||
| The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models | Q38736457 | ||
| SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death. | Q38755803 | ||
| Mitochondria-Judges and Executioners of Cell Death Sentences | Q38760561 | ||
| Killing Lymphoma with Smac-Mimetics: As Easy as ABC? | Q38778883 | ||
| Developmental checkpoints guarded by regulated necrosis | Q38801509 | ||
| Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy | Q38828950 | ||
| Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia | Q39013886 | ||
| Roles of Caspases in Necrotic Cell Death. | Q39041502 | ||
| Necroptosis in development, inflammation and disease. | Q39044997 | ||
| BH3-Only Proteins in Health and Disease | Q39077153 | ||
| Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. | Q30554728 | ||
| Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex | Q30576337 | ||
| The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest | Q30648719 | ||
| The primary cilium functions as a mechanical and calcium signaling nexus | Q30652136 | ||
| Polycystic kidney disease | Q33709685 | ||
| Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition | Q34009416 | ||
| Ferroptosis: an iron-dependent form of nonapoptotic cell death | Q34032093 | ||
| Ferroptosis as a p53-mediated activity during tumour suppression | Q34043533 | ||
| Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins | Q34120390 | ||
| The cell biology of polycystic kidney disease | Q34149966 | ||
| How simple are 'simple renal cysts'? | Q34152248 | ||
| Renal cystic diseases: a review. | Q34492146 | ||
| Polycystic kidney disease: new understanding in the pathogenesis | Q34548724 | ||
| Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway. | Q34654407 | ||
| Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease | Q34982718 | ||
| Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells | Q35035486 | ||
| Roscovitine-induced apoptosis in neutrophils and neutrophil progenitors is regulated by the Bcl-2-family members Bim, Puma, Noxa and Mcl-1 | Q35041268 | ||
| Altered trafficking and stability of polycystins underlie polycystic kidney disease | Q35145360 | ||
| Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1. | Q35228509 | ||
| Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53 | Q35252479 | ||
| The BCL-2 family reunion | Q35568029 | ||
| Murine models of polycystic kidney disease: molecular and therapeutic insights | Q35576595 | ||
| Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity | Q35719978 | ||
| Bim and Bmf in tissue homeostasis and malignant disease | Q35737865 | ||
| Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum | Q35745275 | ||
| Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species | Q36018810 | ||
| Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. | Q36276959 | ||
| The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd | Q36288329 | ||
| What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)? | Q36300882 | ||
| Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity | Q36357916 | ||
| C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent | Q36380929 | ||
| Design of a RCT evaluating the (cost-) effectiveness of a lifestyle intervention for male construction workers at risk for cardiovascular disease: the health under construction study | Q36478655 | ||
| mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex | Q36651027 | ||
| P433 | issue | 1 | |
| P921 | main subject | autosomal dominant polycystic kidney disease | Q15443105 |
| autosomal dominant polycystic kidney | Q2732398 | ||
| P304 | page(s) | 27-39 | |
| P577 | publication date | 2017-05-30 | |
| P1433 | published in | Cell and Tissue Research | Q1524113 |
| P1476 | title | Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD). | |
| P478 | volume | 369 |
| Q47707521 | A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease. |
| Q97423866 | Automated spheroid generation, drug application and efficacy screening using a deep learning classification: a feasibility study |
| Q61814941 | Autophagy in Chronic Kidney Diseases |
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