| scholarly article | Q13442814 |
| P50 | author | John Cambier | Q28112855 |
| David Nemazee | Q68011959 | ||
| P2093 | author name string | D Melamed | |
| R J Benschop | |||
| P2860 | cites work | Genes and antibodies | Q28185156 |
| Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification | Q28259085 | ||
| Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair | Q28586758 | ||
| Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice | Q28593186 | ||
| Somatic generation of antibody diversity | Q29616439 | ||
| Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow | Q36230070 | ||
| Relative sensitivity of fetal and newborn mice to induction of hapten-specific B cell tolerance | Q36344178 | ||
| Receptor editing: an approach by autoreactive B cells to escape tolerance | Q36361497 | ||
| Receptor editing in self-reactive bone marrow B cells | Q36361578 | ||
| The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver | Q36362209 | ||
| Cross-linking of membrane immunoglobulin D, in the absence of T cell help, kills mature B cells in vivo | Q36364373 | ||
| B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. | Q36367608 | ||
| Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development | Q36376789 | ||
| Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells | Q36380837 | ||
| Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. | Q36562230 | ||
| Peripheral deletion of self-reactive B cells | Q37209432 | ||
| Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease | Q37600558 | ||
| Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires | Q37689611 | ||
| Cellular mechanisms of immunologic tolerance | Q40204557 | ||
| B-lineage differentiation stages resolved by multiparameter flow cytometry | Q40374350 | ||
| Origins of anti-DNA antibodies and their implications for B-cell tolerance | Q40374412 | ||
| Positive and negative selection events during B lymphopoiesis | Q40404760 | ||
| The B-cell antigen receptor complex and co-receptors | Q40422812 | ||
| Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. | Q40447898 | ||
| Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage | Q40661103 | ||
| Negative selection of lymphocytes | Q40807431 | ||
| Clonal selection and learning in the antibody system | Q41002744 | ||
| Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements | Q41039729 | ||
| The "clonal selection hypothesis" and current concepts of B cell tolerance | Q41113352 | ||
| BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro | Q41118611 | ||
| Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens | Q41170875 | ||
| Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement | Q41278530 | ||
| Receptor editing, immune diversification, and self-tolerance | Q41295575 | ||
| B cell development and differentiation | Q41429647 | ||
| Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation | Q41471367 | ||
| Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci | Q41522821 | ||
| The influence of S17 stromal cells and interleukin 7 on B cell development | Q41719058 | ||
| Transitional B cells are the target of negative selection in the B cell compartment | Q42026939 | ||
| Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self | Q42909420 | ||
| Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes | Q43459477 | ||
| Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. | Q52227004 | ||
| A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively | Q55888521 | ||
| Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice | Q57222709 | ||
| Receptor-mediated inactivation of early B lymphocytes | Q59078948 | ||
| Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes | Q59098044 | ||
| Inhibition of lipopolysaccharide-induced activation of immature B cells by anti-mu and anti-delta antibodies and its modulation by interleukin-4 | Q68009411 | ||
| The kappa/lambda ratio in surface immunoglobulin molecules on B lymphocytes differentiating from DHJH-rearranged murine pre-B cell clones in vitro | Q68036537 | ||
| Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli | Q71011992 | ||
| IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development | Q71659842 | ||
| The status of Ig loci rearrangements in single cells from different stages of B cell development | Q71785803 | ||
| A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle | Q71952814 | ||
| Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice | Q72707887 | ||
| Editing disease-associated autoantibodies | Q73115270 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 173-182 | |
| P577 | publication date | 1998-01-01 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection | |
| P478 | volume | 92 |
| Q35080761 | A B-cell receptor-specific selection step governs immature to mature B cell differentiation |
| Q42945090 | A Fail-safe Mechanism for Negative Selection of Isotype-switched B Cell Precursors Is Regulated by the Fas/FasL Pathway |
| Q46283604 | A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. |
| Q73256371 | A negative regulatory role for Ig-alpha during B cell development |
| Q22305702 | A role for MHC class II antigen processing in B cell development |
| Q37220784 | A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. |
| Q40811596 | A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation |
| Q34354933 | A stepwise epigenetic process controls immunoglobulin allelic exclusion |
| Q35220698 | Accumulation of VH Replacement Products in IgH Genes Derived from Autoimmune Diseases and Anti-Viral Responses in Human |
| Q31859010 | Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. |
| Q33919653 | Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies |
| Q36528869 | Aging and neoteny in the B lineage |
| Q36433369 | An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro |
| Q34076152 | Antibody regulation of B cell development |
| Q37584440 | Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire |
| Q36404067 | Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells |
| Q35084274 | Antigen receptor selection by editing or downregulation of V(D)J recombination. |
| Q40815606 | Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells |
| Q45861565 | Augmentation of natural immunity to a pro-inflammatory cytokine (TNF-alpha) by targeted DNA vaccine confers long-lasting resistance to experimental autoimmune encephalomyelitis |
| Q33869680 | B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. |
| Q33632426 | B cell development: signal transduction by antigen receptors and their surrogates. |
| Q27692084 | B cell receptor editing in tolerance and autoimmunity |
| Q35160339 | B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection. |
| Q35591032 | B-cell antigen-receptor signalling in lymphocyte development |
| Q46203018 | BAFF-R expression correlates with positive selection of immature B cells. |
| Q24795003 | Basal immunoglobulin signaling actively maintains developmental stage in immature B cells |
| Q33707566 | Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright |
| Q36369010 | Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse |
| Q55035653 | CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals. |
| Q35693742 | CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools |
| Q39303549 | Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity. |
| Q38239274 | Calcium channels in Fc receptor signaling |
| Q42591172 | Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen |
| Q74268401 | Circulating human B cells that express surrogate light chains and edited receptors |
| Q40963135 | Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis |
| Q40625132 | Clustering of the B Cell Receptor Is Not Required for the Apoptotic Response |
| Q73934023 | Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling |
| Q35991469 | Complement receptors and the shaping of the natural antibody repertoire |
| Q59066328 | Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion |
| Q34612574 | Contribution of V(H) replacement products in mouse antibody repertoire |
| Q38302173 | CpG DNA stimulates autoreactive immature B cells in the bone marrow |
| Q35160175 | Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes |
| Q33957672 | Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines |
| Q36375334 | Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. |
| Q41860405 | Dynamics of suppressor T cells: in vivo veritas |
| Q35032627 | Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism |
| Q42944750 | Essential immunoregulatory role for BCAP in B cell development and function |
| Q46053556 | Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation |
| Q41829345 | Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment |
| Q57078475 | Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing |
| Q89295103 | Foxo3 Promotes Apoptosis of B Cell Receptor-Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing |
| Q73065676 | Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells |
| Q73179244 | Functional analysis of the human RAG 2 promoter |
| Q33898975 | Functional dissection of BCR signaling pathways |
| Q34772077 | Haplotype exclusion and receptor editing: irreconcilable differences? |
| Q94550943 | Homeostasis and regulation of autoreactive B cells |
| Q36399885 | Human autoantibody silencing by immunoglobulin light chains |
| Q35627706 | Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. |
| Q77754816 | Immune receptor editing: revise and select |
| Q36368599 | Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production |
| Q26865940 | Immunological aspects in chronic lymphocytic leukemia (CLL) development |
| Q79180847 | Kinetics of the Apoptotic Response Induced by Anti-IgM Engagement of the B Cell Receptor Is Dependent on the Density of Cell Surface Immunoglobulin M Expression |
| Q34516535 | Maintenance and loss of self-tolerance in B cells |
| Q39214736 | Mechanisms of central tolerance for B cells. |
| Q44688347 | Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes |
| Q24293087 | NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling |
| Q77328508 | Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter |
| Q33869858 | Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. |
| Q42124822 | Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing |
| Q35176393 | Positive and negative selection during B lymphocyte development |
| Q73416026 | Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk |
| Q35080394 | Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells |
| Q36388685 | Potential contribution of VH gene replacement in immunity and disease |
| Q54637388 | Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity |
| Q62605975 | RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues |
| Q36642612 | Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo |
| Q33730095 | Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation |
| Q38205441 | RasGRP Ras guanine nucleotide exchange factors in cancer |
| Q51097493 | Receptor editing and commitment in B lymphocytes. |
| Q36455313 | Receptor editing and genetic variability in human autoreactive B cells. |
| Q36399448 | Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A |
| Q73035421 | Receptor editing in developing T cells |
| Q36401586 | Receptor editing occurs frequently during normal B cell development. |
| Q52015874 | Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. |
| Q33932667 | Receptor selection in B and T lymphocytes |
| Q47927263 | Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes |
| Q36229153 | Reduced receptor editing in lupus-prone MRL/lpr mice |
| Q34612524 | Regulation of B cell fates by BCR signaling components |
| Q33860573 | Regulation of RAG expression in developing lymphocytes |
| Q36863774 | Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells |
| Q33935117 | Revising B cell receptors |
| Q33942075 | Role of B cell antigen receptor in regulation of V(D)J recombination and cell survival |
| Q37260841 | Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition |
| Q36759087 | STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. |
| Q33889470 | Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase |
| Q33683189 | Signal transduction pathways that regulate the fate of B lymphocytes. |
| Q42149724 | Somatic hypermutation targeting is influenced by location within the immunoglobulin V region |
| Q33954374 | T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis |
| Q34038580 | TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23. |
| Q59812988 | The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development |
| Q43421877 | The human uniqueness of HIV: innate immunity and the viral Tat protein |
| Q35076679 | Thymic selection revisited: how essential is it? |
| Q36974265 | Understanding B-cell tolerance through the use of immunoglobulin transgenic models |
| Q35911221 | V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling |
| Q33606245 | c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells |
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