| P50 | author | David Nemazee | Q68011959 |
| P2093 | author name string | David Nemazee | |
| P2860 | cites work | B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk | Q24299839 |
| | IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans | Q24314442 |
| | The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 | Q24319764 |
| | Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma | Q24613755 |
| | SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation | Q24645697 |
| | The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus | Q24647015 |
| | Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis | Q24669916 |
| | Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail | Q24675475 |
| | Basal immunoglobulin signaling actively maintains developmental stage in immature B cells | Q24795003 |
| | Polyreactive Antibodies: Function and Quantification | Q26999862 |
| | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation | Q27022974 |
| | Biomarkers to guide clinical therapeutics in rheumatology? | Q28080053 |
| | Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development | Q28206720 |
| | Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification | Q28259085 |
| | Receptor editing is the main mechanism of B cell tolerance toward membrane antigens | Q28262805 |
| | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection | Q28270723 |
| | C3d of complement as a molecular adjuvant: bridging innate and acquired immunity | Q28272810 |
| | The FoxO code | Q28275268 |
| | Signaling by the phosphoinositide 3-kinase family in immune cells | Q28283677 |
| | Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing | Q28504966 |
| | RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci | Q28508203 |
| | Syk tyrosine kinase required for mouse viability and B-cell development | Q28586985 |
| | Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 | Q28592092 |
| | CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification | Q28613558 |
| | Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop | Q28613911 |
| | Somatic generation of antibody diversity | Q29616439 |
| | Predominant autoantibody production by early human B cell precursors | Q29619656 |
| | Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization | Q31838023 |
| | B cell antigen receptor signaling and internalization are mutually exclusive events | Q33244376 |
| | B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage | Q33286220 |
| | Foxo1 directly regulates the transcription of recombination-activating genes during B cell development | Q33333434 |
| | Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo | Q33615157 |
| | Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation | Q33730095 |
| | A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models | Q36802757 |
| | The human immunoglobulin κ locus on yeast artificial chromosomes (YACs) | Q36870370 |
| | Specific peripheral B cell tolerance defects in patients with multiple sclerosis | Q36890946 |
| | B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice | Q36920508 |
| | B-cell self-tolerance in humans | Q36942517 |
| | Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells | Q37066101 |
| | Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases | Q37091486 |
| | Role of Syk in B-cell development and antigen-receptor signaling | Q37114681 |
| | Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs | Q37153957 |
| | Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. | Q37183404 |
| | CVID-associated TACI mutations affect autoreactive B cell selection and activation | Q37206886 |
| | A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. | Q37220784 |
| | NF-kappaB activity marks cells engaged in receptor editing | Q37292774 |
| | Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization | Q37343139 |
| | Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals | Q37344357 |
| | Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci | Q37377456 |
| | Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling | Q37400609 |
| | Cracking the BAFF code. | Q37517172 |
| | Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity? | Q37678661 |
| | Control systems and decision making for antibody production. | Q37774242 |
| | The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases | Q37974981 |
| | New insights into pre-BCR and BCR signalling with relevance to B cell malignancies | Q38123936 |
| | B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements | Q38292514 |
| | Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. | Q38293488 |
| | Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions | Q39301124 |
| | CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells | Q39409241 |
| | Transgenic mice with immunoglobulin genes | Q39595449 |
| | Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu | Q70338853 |
| | Editing disease-associated autoantibodies | Q73115270 |
| | A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro | Q73709074 |
| | Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA autoantibodies from low-affinity precursors | Q73852046 |
| | VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus | Q74261418 |
| | The PI3K p110delta is required for down-regulation of RAG expression in immature B cells | Q79717937 |
| | In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance | Q80345129 |
| | Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells | Q80582372 |
| | Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice | Q80967853 |
| | Arginine methylation of the B cell antigen receptor promotes differentiation. | Q33794949 |
| | Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. | Q33835200 |
| | High throughput cellular screens to interrogate the human T and B cell repertoires | Q33907471 |
| | Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies | Q33919653 |
| | A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate | Q33961160 |
| | Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency | Q33979850 |
| | Bam32 Links the B Cell Receptor to ERK and JNK and Mediates B Cell Proliferation but Not Survival | Q34270517 |
| | Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. | Q34303713 |
| | Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras | Q34313426 |
| | The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization | Q34360396 |
| | Antigen receptors on B lymphocytes | Q34420640 |
| | Responsiveness of B cells is regulated by the hinge region of IgD. | Q34470602 |
| | Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization | Q34544332 |
| | Receptor editing in lymphocyte development and central tolerance. | Q34568574 |
| | Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs | Q34571456 |
| | Oligomeric organization of the B-cell antigen receptor on resting cells | Q34623132 |
| | Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how? | Q34772100 |
| | VH replacement in primary immunoglobulin repertoire diversification. | Q35062818 |
| | Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production | Q35081657 |
| | Activation-induced cytidine deaminase mediates central tolerance in B cells | Q35105238 |
| | HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development | Q35172770 |
| | The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans | Q35187072 |
| | PTPN22: the archetypal non-HLA autoimmunity gene | Q35221741 |
| | Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape | Q35582239 |
| | The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models | Q35589858 |
| | Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation | Q35776056 |
| | Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. | Q35784452 |
| | The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. | Q35930798 |
| | The scope of receptor editing and its association with autoimmunity | Q35931602 |
| | Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b | Q35940280 |
| | B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome | Q35957443 |
| | Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy | Q36005403 |
| | The B-cell antigen receptor integrates adaptive and innate immune signals | Q36120391 |
| | The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire | Q36184410 |
| | Reduced receptor editing in lupus-prone MRL/lpr mice | Q36229153 |
| | Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance | Q36304376 |
| | Receptor editing: an approach by autoreactive B cells to escape tolerance | Q36361497 |
| | Receptor editing in self-reactive bone marrow B cells | Q36361578 |
| | B lymphocytes may escape tolerance by revising their antigen receptors | Q36361618 |
| | Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance | Q36364008 |
| | Light chain replacement: a new model for antibody gene rearrangement | Q36365220 |
| | Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. | Q36368404 |
| | Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse | Q36369010 |
| | Autoreactive B cells in the marginal zone that express dual receptors | Q36369869 |
| | Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells | Q36371743 |
| | Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development | Q36376789 |
| | Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells | Q36380837 |
| | Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool | Q36380979 |
| | Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A | Q36399448 |
| | Human autoantibody silencing by immunoglobulin light chains | Q36399885 |
| | Receptor editing occurs frequently during normal B cell development. | Q36401586 |
| | Defective B cell tolerance checkpoints in systemic lupus erythematosus | Q36402748 |
| | Impaired early B cell tolerance in patients with rheumatoid arthritis. | Q36402969 |
| | Bruton's tyrosine kinase is essential for human B cell tolerance | Q36403841 |
| | ITAM-mediated tonic signalling through pre-BCR and BCR complexes | Q36430140 |
| | Rituximab does not reset defective early B cell tolerance checkpoints | Q36430775 |
| | Receptor editing and genetic variability in human autoreactive B cells. | Q36455313 |
| | A role for interferon regulatory factor 4 in receptor editing | Q36540253 |
| | RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals | Q36569363 |
| | TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation | Q36585700 |
| | Ordered rearrangement of immunoglobulin heavy chain variable region segments | Q36586574 |
| | The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements | Q36603553 |
| | STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. | Q36759087 |
| | Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice | Q36763279 |
| | The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway. | Q36768345 |
| | Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors | Q36775342 |
| | The MAPK/ERK and PI3K pathways additively coordinate the transcription of recombination-activating genes in B lineage cells | Q39667386 |
| | Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. | Q39668203 |
| | A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation | Q39793982 |
| | Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells | Q39904891 |
| | Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. | Q40429324 |
| | Genetic and structural evidence for antigen selection of anti-DNA antibodies. | Q40661152 |
| | Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization | Q40696448 |
| | Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk. | Q40987517 |
| | Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry. | Q41103048 |
| | The "clonal selection hypothesis" and current concepts of B cell tolerance | Q41113352 |
| | Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens | Q41170875 |
| | Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. | Q41423746 |
| | Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines | Q41528179 |
| | In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire | Q41602128 |
| | Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. | Q41708790 |
| | BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation | Q41780823 |
| | CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway | Q41789207 |
| | PI3 kinase signals BCR-dependent mature B cell survival | Q41886641 |
| | Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production | Q41911438 |
| | Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways | Q41969243 |
| | Overexpression of Fkbp11, a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation | Q41991228 |
| | Transitional B cells are the target of negative selection in the B cell compartment | Q42026939 |
| | PTPN22 inhibition resets defective human central B cell tolerance | Q42059400 |
| | Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing | Q42124822 |
| | Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. | Q42678843 |
| | Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice. | Q42799157 |
| | Reduced life span of anergic self-reactive B cells in a double-transgenic model | Q42942098 |
| | Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation | Q43760103 |
| | Receptor editing in CD45-deficient immature B cells | Q44124111 |
| | The physiologic role of CD19 cytoplasmic tyrosines | Q44184966 |
| | Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function | Q44379293 |
| | Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. | Q44410226 |
| | Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes | Q44688347 |
| | Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice | Q46073605 |
| | Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. | Q46109491 |
| | Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase | Q46891828 |
| | Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. | Q47713262 |
| | Clustered arrangement of immunoglobulin λ constant region genes in man | Q48407182 |
| | Molecular components of the B-cell antigen receptor complex of the IgM class | Q50335807 |
| | A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency. | Q50502479 |
| | Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain. | Q52110038 |
| | Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. | Q52190945 |
| | In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. | Q52192552 |
| | The site and stage of anti-DNA B-cell deletion. | Q52210540 |
| | Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. | Q52227004 |
| | Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. | Q52525223 |
| | BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. | Q53455269 |
| | SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. | Q53959197 |
| | Defects in the CD19 complex predispose to glomerulonephritis, as well as IgG1 subclass deficiency | Q56939872 |
| | Contribution of Receptor Editing to the Antibody Repertoire | Q57198265 |
| | B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain | Q57198310 |
| | A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice | Q57198348 |
| | Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development | Q57198364 |
| | Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice | Q57222709 |
| | Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice | Q59065295 |
| | Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes | Q59098044 |
| | Re-evaluation of the probabilities for productive rearrangements on the κ andλloci | Q63965565 |
| P433 | issue | 5 | |
| P304 | page(s) | 281-294 | |
| P577 | publication date | 2017-04-03 | |
| P1433 | published in | Nature Reviews Immunology | Q43355 |
| P1476 | title | Mechanisms of central tolerance for B cells | |
| P478 | volume | 17 | |