David Nemazee

researcher

David Nemazee is …
instance of (P31):
humanQ5

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P269IdRef ID223952923
P213ISNI0000000026475283
P496ORCID iD0000-0002-4769-6311
P214VIAF ID24822370

P735given nameDavidQ18057751
DavidQ18057751
P106occupationresearcherQ1650915
P5008on focus list of Wikimedia projectWikiProject COVID-19Q87748614
P21sex or gendermaleQ6581097

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author (P50)
Q73709074A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro
Q73535809A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors
Q100387966A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody
Q37220784A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.
Q78233407Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse
Q102380766An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19
Q36402702An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system
Q71197127Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes
Q41136316Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.
Q37316819Antigen receptor 'capacity' and the sensitivity of self-tolerance.
Q35084274Antigen receptor selection by editing or downregulation of V(D)J recombination.
Q36404230Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.
Q104111171Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
Q35160339B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.
Q37220772B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice
Q36367608B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.
Q98890585B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
Q37171260B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates
Q68011961B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras
Q37183404Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.
Q96429124Broad neutralization of SARS-related viruses by human monoclonal antibodies
Q112715402Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
Q59098044Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
Q57198265Contribution of Receptor Editing to the Antibody Repertoire
Q33615157Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo
Q55313333Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.
Q36811047Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.
Q24309087DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF
Q41611835Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
Q92184345Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
Q52190945Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.
Q36375334Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.
Q71556149Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory
Q82704548Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen
Q36404207Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes
Q46493549Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology.
Q36300341Enhancing antibody: a novel component of the immune response.
Q24652635FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles
Q57222709Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
Q40053462Generation of T-follicular helper cells in vitro: requirement for BCR cross-linking and cognate B- and T-cell interaction.
Q36345558HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
Q59339672HIV-1 vaccine design through minimizing envelope metastability
Q36957800High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.
Q41870758Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.
Q34494308Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity.
Q68126711Inability of IL-2 and IL-10 to counteract B cell clonal deletion
Q36348899Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response
Q96429194Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Q34681437Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.
Q36325225Mechanisms and meaning of B-lymphocyte tolerance.
Q39214736Mechanisms of central tolerance for B cells.
Q35582239Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape
Q90967071PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
Q54593961Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.
Q33869858Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Q35915043Peripheral B lymphocyte tolerance.
Q47232975Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens
Q37060947Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
Q40809007Promotion and prevention of autoimmunity by B lymphocytes.
Q46987046Rational immunogen design to target specific germline B cell receptors
Q36455313Receptor editing and genetic variability in human autoreactive B cells.
Q36399448Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A
Q34568574Receptor editing in lymphocyte development and central tolerance.
Q37220764Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.
Q36401586Receptor editing occurs frequently during normal B cell development.
Q33743324Receptor editing: genetic reprogramming of autoreactive lymphocytes.
Q37153957Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
Q35686885Regulation of the B cell receptor repertoire and self-reactivity by BAFF
Q36751836Role of RS/kappaDE in B cell receptor editing.
Q34338742Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.
Q36562230Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.
Q35784452Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.
Q98467301Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
Q100750028Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
Q98384046Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
Q37246321Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
Q59488222Targeting cytotoxic T cells to antigen-specific B lymphocytes
Q46490359The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.
Q36659226The design and implementation of the immune epitope database and analysis resource
Q24804461The immune epitope database and analysis resource: from vision to blueprint
Q35930798The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.
Q41711151Theoretical limits to massive receptor editing in immature B cells.
Q35666716Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.
Q73086202Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice
Q56687402V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses
Q102141512Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
Q36353493Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.

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