Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

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Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20031180
P932PMC publication ID2211894
P698PubMed publication ID15078898
P5875ResearchGate publication ID8623863

P50authorDavid NemazeeQ68011959
Cornelis MurreQ94947744
P2093author name stringAnton W Langerak
Richard R Rivera
Melanie W Quong
Annica Martensson
P2860cites workFunctions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEBQ24290138
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsQ24299387
B-cell-specific DNA binding by an E47 homodimerQ24651446
Marginal-zone B cellsQ28201000
Gradient of E2A activity in B-cell developmentQ28215170
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangementsQ28243194
The helix-loop-helix gene E2A is required for B cell formationQ28504830
Aiolos regulates B cell activation and maturation to effector stateQ28505020
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral responseQ28590125
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascadeQ31929689
Developmental regulation of immune system gene rearrangementQ33536540
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation systemQ34381016
The function of E- and Id proteins in lymphocyte developmentQ34572188
Receptor editing: an approach by autoreactive B cells to escape toleranceQ36361497
Receptor editing in self-reactive bone marrow B cellsQ36361578
B lymphocytes may escape tolerance by revising their antigen receptorsQ36361618
Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47Q36375680
Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cellsQ36376267
Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.Q36404030
Ordered rearrangement of immunoglobulin heavy chain variable region segmentsQ36586574
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteinsQ36686388
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activitiesQ37368153
Failure of B-cell differentiation in mice lacking the transcription factor EBF.Q38293381
Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangementQ38359938
Notch inhibition of E47 supports the existence of a novel signaling pathwayQ39631179
E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cellsQ40869804
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.Q40937465
B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stagesQ40938572
Clonal selection and learning in the antibody systemQ41002744
Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elementsQ41039729
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell lineQ41672433
Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.Q41717817
Early thymocyte development is regulated by modulation of E2A protein activityQ41828914
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chainsQ42939402
Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-betaQ46116890
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.Q46283604
Control of pre-BCR signaling by Pax5-dependent activation of the BLNK geneQ48277541
A uniform deleting element mediates the loss of kappa genes in human B cellsQ48377034
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.Q52190945
Contribution of Receptor Editing to the Antibody RepertoireQ57198265
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAPQ58326934
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizionQ59066328
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genesQ59098044
Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcriptionQ69230362
Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin muQ70338853
Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probesQ77653638
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmarginal zone B-cellQ6760431
P304page(s)1101-1112
P577publication date2004-04-12
P1433published inJournal of Experimental MedicineQ3186912
P1476titleReceptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A
P478volume199

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cites work (P2860)
Q33961160A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
Q36540253A role for interferon regulatory factor 4 in receptor editing
Q37220784A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.
Q33509909A tamoxifen inducible knock-in allele for investigation of E2A function
Q35607200Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma
Q36477926Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome.
Q27692084B cell receptor editing in tolerance and autoimmunity
Q36121005B cells, E2A, and aging
Q35943310Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47.
Q35992205CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.
Q36570650Central and peripheral RAG protein re-expression: underestimate mechanisms of tolerance?
Q38197232Chronic lymphocytic leukaemia: could immunological tolerance mechanisms be the origin of lymphoid neoplasms?
Q34238693Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses
Q39026380Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells
Q37377456Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
Q24301680E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells
Q83146478E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia
Q34134744E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response
Q39926821E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors
Q24630870Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
Q36963398Epigenetics of antigen-receptor gene assembly
Q28300080Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision
Q36292892Helix-loop-helix proteins and lymphocyte development
Q36121801IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
Q30629726Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Q41193753Id3 Orchestrates Germinal Center B Cell Development.
Q39214736Mechanisms of central tolerance for B cells.
Q37345121NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors
Q36544048New insights into the cell biology of the marginal zone of the spleen
Q31068235Notch-RBP-J-independent marginal zone B cell development in IgH transgenic mice with VH derived from a natural polyreactive antibody
Q36986138Notch-regulated periphery B cell differentiation involves suppression of E protein function
Q81546593Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations
Q42054290Rap signaling in normal lymphocyte development and leukemia genesis
Q36794296Regulation of lymphocyte development by Notch signaling
Q28264813Structure and function of the spleen
Q35011166The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells
Q37644905The Bright Side of Hematopoiesis: Regulatory Roles of ARID3a/Bright in Human and Mouse Hematopoiesis.
Q64079597The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification
Q28586332The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning
Q34505960The endocytic adaptor Eps15 controls marginal zone B cell numbers
Q37621246The follicular versus marginal zone B lymphocyte cell fate decision
Q38546601The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.
Q24645273Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
Q42143359Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells
Q46760945Transcriptional regulator Id2 mediates CD8+ T cell immunity.
Q37785198Two Opposing Roles of RBP-J in Notch Signaling

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