Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

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Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.20.18.6677-6685.2000
P932PMC publication ID86175
P698PubMed publication ID10958665
P5875ResearchGate publication ID12362642

P2093author name stringM Dai
Y Zhuang
R J Barndt
P2860cites workProfound block in thymocyte development in mice lacking p56lckQ24298882
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsQ24299387
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequenceQ24300878
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell LineageQ24310740
HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory FactorsQ24328835
B-cell-specific DNA binding by an E47 homodimerQ24651446
Essential role of LAT in T cell developmentQ28141618
The protein Id: a negative regulator of helix-loop-helix DNA binding proteinsQ28237471
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangementsQ28243194
The helix-loop-helix gene E2A is required for B cell formationQ28504830
Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1Q28513432
Transcription factor GATA-3 is required for development of the T-cell lineageQ28587190
The Ikaros gene is required for the development of all lymphoid lineagesQ28594316
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domainsQ33641257
Functional replacement of the mouse E2A gene with a human HEB cDNA.Q33773768
Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Q33961170
The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma proteinQ34323413
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutationQ34412659
Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancerQ36376708
Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.Q36404030
B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.Q36560174
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteinsQ36686388
A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell linesQ36700487
Helix-loo-helix proteins in the regulation of immunoglobulin gene transcriptionQ36774107
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.Q38321834
Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic miceQ39449305
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomasQ40023076
E47 activates the Ig-heavy chain and TdT loci in non-B cells.Q41077263
EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genesQ41101434
T-cell specific rearrangement of T-cell receptor beta transgenes in miceQ41206301
Early alpha beta T cell development in the thymus of normal and genetically altered miceQ41429677
Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH proteinQ41581566
Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell lineQ41672433
Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitorsQ41828305
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.Q42951830
Both E12 and E47 allow commitment to the B cell lineageQ45129651
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptorQ46155874
alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinasesQ46505598
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.Q47720762
A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.Q52174670
Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages.Q52174703
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.Q52225033
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.Q52511681
An HMG-box-containing T-cell factor required for thymocyte differentiation.Q59058515
T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult miceQ71680581
Constitutive expression of the Id1 gene impairs mouse B cell developmentQ71988116
An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperaturesQ71988142
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectprotein homodimerization activityQ14762996
transcription factor 3Q21111604
Transcription factor 12Q21984287
P304page(s)6677-85
P577publication date2000-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleFunctions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB
P478volume20

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