E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression.

scientific article published on 11 March 2004

E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M402145200
P698PubMed publication ID15016815

P50authorRho SeongQ59749830
P2093author name stringChangjin Lee
Myunggon Ko
Heekyoung Chung
Jeongeun Ahn
Sung H Jeon
Hee-Y Chung
P2860cites workFunctions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEBQ24290138
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsQ24299387
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequenceQ24300878
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motifQ24305878
HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory FactorsQ24328835
Helix-loop-helix proteins: regulators of transcription in eucaryotic organismsQ24554353
B-cell-specific DNA binding by an E47 homodimerQ24651446
E protein function in lymphocyte developmentQ28203458
The protein Id: a negative regulator of helix-loop-helix DNA binding proteinsQ28237471
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangementsQ28243194
Structure and function of helix-loop-helix proteinsQ28244116
The role of E-proteins in B- and T-lymphocyte developmentQ28273104
The helix-loop-helix gene E2A is required for B cell formationQ28504830
An Id-related helix-loop-helix protein encoded by a growth factor-inducible geneQ28512610
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimersQ33332420
Transcriptional control of T cell developmentQ33898960
Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expressionQ33943117
TOX: an HMG box protein implicated in the regulation of thymocyte selectionQ34114649
The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma proteinQ34323413
The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3Q34808300
Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomasQ34945511
Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cellsQ36367756
Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47Q36375680
A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell lineQ36377231
The E2A gene product contains two separable and functionally distinct transcription activation domainsQ36507951
The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cellsQ36556697
High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout miceQ36574096
A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cellsQ36660430
A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell linesQ36700487
E2A proteins enforce a proliferation checkpoint in developing thymocytesQ39315636
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomasQ40023076
Peripheral T cells become sensitive to glucocorticoid- and stress-induced apoptosis in transgenic mice overexpressing SRG3.Q40794231
Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possiblein vitro model for positive selection of the T cell repertoireQ41152049
Inhibition of myeloid differentiation by the helix-loop-helix protein IdQ41634061
Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.Q41717817
Early thymocyte development is regulated by modulation of E2A protein activityQ41828914
Both E12 and E47 allow commitment to the B cell lineageQ45129651
T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation.Q47962945
Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture.Q51111516
In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement.Q51116098
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
P304page(s)21916-21923
P577publication date2004-03-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleE2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression
P478volume279

Reverse relations

cites work (P2860)
Q24317756BAF60a interacts with p53 to recruit the SWI/SNF complex
Q42709956Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.
Q38767130Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology.
Q43988359LymphTF-DB: a database of transcription factors involved in lymphocyte development
Q44928949Nitric oxide inhibits glucocorticoid-induced apoptosis of thymocytes by repressing the SRG3 expression.
Q40341375Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter.
Q28592472SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation
Q51040026Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.
Q47962945T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation.
Q37381007UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3.

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