NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors

scientific article published on 24 March 2009

NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MAD.2009.03.002
P932PMC publication ID2743292
P698PubMed publication ID19428458
P5875ResearchGate publication ID24414127

P2093author name stringAnjali Prabhu
Bonnie B Blomberg
Patricia Keating
Richard L Riley
Anne M King
P2860cites workThe helix-loop-helix gene E2A is required for B cell formationQ28504830
Cell intrinsic alterations underlie hematopoietic stem cell aging.Q33858894
E2A proteins: essential regulators at multiple stages of B-cell developmentQ33996271
B-cell commitment: deciding on the playersQ35084264
Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitorsQ35828776
Interactions between NK cells and B lymphocytesQ35832497
Bone marrow microenvironmental changes in aged mice compromise V(D)J recombinase activity and B cell generationQ36166786
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cellsQ36229123
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitorsQ36366140
Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2AQ36399448
Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged miceQ36399584
Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.Q36404030
Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell developmentQ36407229
B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.Q36560174
Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging.Q36835338
Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expressionQ37359108
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activitiesQ37368153
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.Q40937465
The role of BSAP (Pax-5) in B-cell developmentQ41005385
EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genesQ41101434
Role of murine NK cells and their receptors in hybrid resistanceQ41353132
Allorecognition by murine natural killer cells: lysis of T-lymphoblasts and rejection of bone-marrow graftsQ41373619
In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infectionQ41491872
Relationships between B-lineage lymphocytes and stromal cells in long-term bone marrow culturesQ43735209
Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alphaQ44223891
Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosisQ44633425
Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnoverQ44968876
Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivoQ45231990
Murine lymphokine-activated killer (LAK) cells: phenotypic characterization of the precursor and effector cellsQ46075479
Calcitonin gene-related peptide indirectly inhibits IL-7 responses in pre-B cells by induction of IL-6 and TNF-alpha in bone marrow.Q51037917
Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement.Q52135602
Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment.Q52182767
Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages.Q54450959
Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta.Q54551344
IL-15 is an essential mediator of peripheral NK-cell homeostasisQ58478746
B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitroQ70127792
Cytokine production and heterogeneity of primary stromal cells that support B lymphopoiesisQ72863889
Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factorsQ73064327
Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptorQ73767616
The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteinsQ74317621
Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged miceQ78762514
Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activationQ79880417
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responsesQ80918088
Receptors and counterreceptors involved in NK-B cell interactionsQ81546523
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbone marrowQ546523
P304page(s)384-392
P577publication date2009-03-24
P1433published inMechanisms of Ageing and DevelopmentQ1839797
P1476titleNK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors
P478volume130

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cites work (P2860)
Q42275311Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.
Q52322881Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.
Q33666891Aging of the innate immune system
Q37935622Cognitive and behavioral consequences of impaired immunoregulation in aging
Q37679476Impaired B lymphopoiesis in old age: a role for inflammatory B cells?
Q35527180In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells
Q37026934In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors
Q50166054Inflammatory immune cells may impair the PreBCR checkpoint, reduce new B cell production, and Alter the antibody repertoire in old age.
Q33705348Natural killer cell development and maturation in aged mice.
Q64079597The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification
Q33804295The effect of ageing on human lymphocyte subsets: comparison of males and females

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