In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells

scientific article published on 27 February 2015

In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/ACEL.12302
P932PMC publication ID4406667
P698PubMed publication ID25727904
P5875ResearchGate publication ID272946869

P50authorSandra S. ZinkelQ91232359
P2093author name stringWasif N Khan
Bonnie B Blomberg
Daniela Frasca
Sarah Alter
Jacqueline A Wright
Richard L Riley
Michelle Ratliff
Kelly McAvoy
P2860cites workB lymphocytes express and lose syndecan at specific stages of differentiationQ24596510
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow nicheQ24657562
Aging up-regulates expression of inflammatory mediators in mouse adipose tissueQ28249416
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune diseaseQ28513752
The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chainQ28594115
A B-cell subset uniquely responsive to innate stimuli accumulates in aged miceQ35153782
Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of BimQ35320797
The transition of pre-BI to pre-BII cells is dependent on the VH structure of the mu/surrogate L chain receptorQ35846753
Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsetsQ36060190
A molecular mechanism for TNF-α-mediated downregulation of B cell responsesQ36979267
In senescence, age‐associated B cells secrete TNFα and inhibit survival of B‐cell precursors*Q37026934
NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursorsQ37345121
Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expressionQ37359108
B cells and aging: molecules and mechanismsQ37398750
Impaired B lymphopoiesis in old age: a role for inflammatory B cells?Q37679476
B lymphocyte-specific, Cre-mediated mutagenesis in miceQ39719513
Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signalsQ40247901
Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells.Q40943970
Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chainsQ41015079
EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genesQ41101434
A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell linesQ41536897
Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosisQ44633425
Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnoverQ44968876
A selective increase in the generation of phosphorylcholine-specific B cells associated with agingQ44989930
Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-betaQ46116890
Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartmentQ52182767
Expression and ontogeny of CD2 on murine B cells.Q53508396
Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificityQ68011978
Altered VH gene segment utilization in the response to phosphorylcholine by aged miceQ69114845
Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiationQ69918537
B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitroQ70127792
Stage-specific alterations in murine B lymphopoiesis with ageQ71162999
Negative selection of multireactive B cell clones in normal adult miceQ72524379
Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell ReceptorQ73767616
The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteinsQ74317621
Increased apoptosis of bone marrow pre-B cells in old mice associated with their low numberQ77457138
Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged miceQ78762514
Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activationQ79880417
Censoring of autoreactive B cell development by the pre-B cell receptorQ81485516
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in agingQ83179102
Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with ageQ83888056
Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B LineageQ84652927
P433issue3
P921main subjectapoptotic processQ14599311
P304page(s)382-390
P577publication date2015-02-27
P1433published inAging CellQ2221073
P1476titleIn aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells
P478volume14

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cites work (P2860)
Q48348426Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation
Q64094881B Cell Dysfunction Associated With Aging and Autoimmune Diseases
Q58763780Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells
Q40439971In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance
Q50166054Inflammatory immune cells may impair the PreBCR checkpoint, reduce new B cell production, and Alter the antibody repertoire in old age.

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