Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

scientific article

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00775-009-0594-5
P932PMC publication ID2814311
P698PubMed publication ID19809836
P5875ResearchGate publication ID225695623

P2093author name stringLei Yang
Ying Sun
Q Ping Dou
Bing Yan
Shumei Zhai
Qiuzhi Cindy Cui
P2860cites workClioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activityQ40030779
Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenograftsQ40169646
Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cellsQ40204682
Anticancer activity of the antibiotic clioquinolQ40434343
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblastsQ40979308
Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell linesQ41753857
Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell modelQ41913417
Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexesQ44944109
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's diseaseQ45091101
Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapyQ45304635
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myelomaQ46406532
Preparation and study of new poly-8-hydroxyquinoline chelators for an anti-Alzheimer strategy.Q46924835
Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumorsQ48297275
Copper and ceruloplasmin status in serum of prostate and colon cancer patientsQ73301562
p53-dependent induction of apoptosis by proteasome inhibitorsQ73334980
Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosisQ73492333
Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF studyQ74581339
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrateQ82458556
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cellsQ21195237
The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancerQ24794927
Synthesis and cytotoxicity evaluation of some 8-hydroxyquinoline derivativesQ28139997
Potential for proteasome inhibition in the treatment of cancerQ28186033
The ubiquitin-proteasome pathway: on protein death and cell lifeQ29619270
Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.Q31155592
Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cellsQ33199028
Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosisQ33217605
Pipes and wiring: the regulation of copper uptake and distribution in yeast.Q33798087
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study.Q33888604
Cellular copper transport and metabolismQ33913533
Tumour vasculature as a target for anticancer therapy.Q33920565
Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's diseaseQ34083391
Proteasome inhibitors as potential novel anticancer agentsQ34086759
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancerQ34195781
Proteasome from Thermoplasma acidophilum: a threonine proteaseQ34309062
Serum and tissue trace metal levels in lung cancerQ34533791
Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugsQ34572035
Acrodermatitis enteropathica and an overview of zinc metabolismQ36693109
The proteasome as a potential target for novel anticancer drugs and chemosensitizersQ36695969
Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells.Q36953350
P433issue2
P921main subjectcopperQ753
P304page(s)259-269
P577publication date2009-10-07
P1433published inJournal of Biological Inorganic ChemistryQ3186899
P1476titleTumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells
P478volume15

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cites work (P2860)
Q368690571,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.
Q93017778A Proteomic View of Cellular Responses to Anticancer Quinoline-Copper Complexes
Q93257503A combination of clioquinol, zinc and copper increases the abundance and function of breast cancer resistance protein in human brain microvascular endothelial cells
Q89638804A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer
Q39307579Biological and cytoselective anticancer properties of copper(II)-polypyridyl complexes modulated by auxiliary methylated glycine ligand
Q39572385Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer.
Q35526682Comparative proteomic analysis of the molecular responses of mouse macrophages to titanium dioxide and copper oxide nanoparticles unravels some toxic mechanisms for copper oxide nanoparticles in macrophages.
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