Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling

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Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0801563
P932PMC publication ID2814438
P698PubMed publication ID19342676
P5875ResearchGate publication ID24254240

P50authorRichard M. PopeQ47819699
P2093author name stringBo Shi
Paul Peter Tak
Qi-Quan Huang
Christopher V Nicchitta
Arthur M Mandelin
Angela R Jockheck-Clark
Rudina Sobkoviak
G Kennith Haines
P2860cites workHeat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophagesQ24609722
APC-derived cytokines and T cell polarization in autoimmune inflammationQ24679426
The endoplasmic reticular heat shock protein gp96 is transcriptionally upregulated in interferon-treated cellsQ24679609
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammationQ28248826
Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritisQ28582484
Evolving concepts of rheumatoid arthritisQ29618020
Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosisQ32045053
Macrophages require constitutive NF-kappaB activation to maintain A1 expression and mitochondrial homeostasisQ33870198
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophagesQ33895703
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viabilityQ34093483
Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responsesQ34115645
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathwayQ34120383
Amelioration of rat adjuvant-induced arthritis by Met-RANTES.Q34130186
Apoptosis as a therapeutic tool in rheumatoid arthritisQ34718143
Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseasesQ34792083
Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synoviumQ35749232
Cells of the synovium in rheumatoid arthritis. T lymphocytes.Q35769049
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseasesQ35855539
The role of macrophages in rheumatoid arthritisQ36048372
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathwaysQ36274956
Heat shock protein and innate immunityQ36286481
Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.Q36369402
FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosisQ36375676
Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritidesQ37876840
GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide productionQ38353637
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokiQ39806745
Induction of heat shock protein gp96 by immune cytokinesQ39957856
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune diseaseQ40212562
Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCsQ40745953
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.Q40751982
Cutting edge: receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells.Q40960957
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritisQ40974392
Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritisQ41623175
Human platelets express heat shock protein receptors and regulate dendritic cell maturationQ43977703
The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functionsQ44225913
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survivalQ44361992
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathwayQ44539124
Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response.Q45261346
Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp)70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-primingQ47368690
Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritisQ47596885
Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammationQ47794865
Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis.Q53644785
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.Q54435250
Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling.Q54528791
Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritisQ62734293
Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokinesQ73092696
Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96Q73694719
Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissueQ75288370
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunityQ77337850
Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP, in experimental arthritisQ77406864
Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60Q78551166
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trialQ80207327
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gammaQ81129108
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritisQ83367358
Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responsesQ83929541
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
rheumatoid arthritisQ187255
toll-like receptorQ408004
P304page(s)4965-4973
P577publication date2009-04-01
P1433published inJournal of ImmunologyQ3521441
P1476titleHeat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling
P478volume182

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