Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

scientific article published on January 2008

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI32639
P932PMC publication ID2104479
P698PubMed publication ID18060042

P50authorMarije KoendersQ38318056
Martin J NicklinQ58684573
Shahla Abdollahi-RoodsazQ89427855
Leo A.B. JoostenQ89547374
Timothy R D J RadstakeQ114341720
Isabel DevesaQ114405418
Marleen Heuvelmans-JacobsQ114405424
P2093author name stringWim B van den Berg
Shizuo Akira
Mieke F Roelofs
Fátima Ribeiro-Dias
P2860cites workIn vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areasQ24652833
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritisQ24796707
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Pathogen recognition and innate immunityQ27861084
STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient miceQ28235220
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
Phenotypic and functional features of human Th17 cellsQ29619323
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophagesQ33895703
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporterQ33936032
The role of different subsets of T regulatory cells in controlling autoimmunityQ34096248
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathwayQ34120383
Influence of the indigenous gastrointestinal microbial flora on duodenal alkaline phosphatase activity in miceQ34171268
Toll-like receptor 2 controls expansion and function of regulatory T cellsQ34264024
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosisQ34312767
CpG motifs in bacterial DNA and their immune effectsQ34542287
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune diseaseQ34556560
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cellsQ34557118
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonistQ35022575
Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synoviumQ35749232
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cellsQ35776179
The distribution of fibronectin in the pannus in rheumatoid arthritis.Q36091597
Arterial inflammation in mice lacking the interleukin 1 receptor antagonist geneQ36375747
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient miceQ36375776
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusionQ36403403
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient miceQ37625825
Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritidesQ37876840
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.Q38594831
Toll-like receptor ligands directly promote activated CD4+ T cell survivalQ39442360
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionQ40590532
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 proteinQ40609759
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.Q40733888
The extra domain A of fibronectin activates Toll-like receptor 4.Q40832345
Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritisQ41101140
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritisQ42853439
Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthmaQ44772766
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathwayQ45178588
IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cellsQ45178622
Cellular fibronectin in rheumatoid synovium and synovial fluid: a possible factor contributing to lymphocytic infiltrationQ45289702
Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitopeQ45748463
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shockQ46962508
Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritisQ47596885
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetesQ47667692
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cellsQ47810460
Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cellsQ47991722
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.Q52956682
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.Q53597450
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.Q54435250
The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses.Q54455967
TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4+ CD25+ T cell.Q54563754
Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.Q54627231
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expressionQ59048389
Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritisQ68112952
A simple sensitive bioassay for interleukin-1 which is unresponsive to 10(3) U/ml of interleukin-2Q68819313
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1RaQ71098362
Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokinesQ73092696
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsQ74179201
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cellsQ74285101
Intra-articularly localized bacterial DNA containing CpG motifs induces arthritisQ77890153
An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitisQ79617034
The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cellsQ80955813
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gammaQ81129108
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritisQ83367358
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritisQ94174926
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)205-216
P577publication date2008-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleStimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
P478volume118

Reverse relations

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