Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.

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Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1046182548
P356DOI10.1186/1471-2164-11-419
P932PMC publication ID2996947
P698PubMed publication ID20604938
P5875ResearchGate publication ID45095932

P50authorKeith O EllistonQ60665773
Dexter PrattQ100953649
P2093author name stringRakesh Kumar
Emanuel F Petricoin
Catherine E Ellis
Michael Macoritto
Stephen J Blakemore
Joseph J Loureiro
Andrea L Matthews
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A transforming mutation in the pleckstrin homology domain of AKT1 in cancerQ27646556
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PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of functionQ33224746
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transportQ33292269
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoQ33417863
GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.Q33596707
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusQ33944754
Rb-mediated chromatin structure regulation and transcriptional repressionQ34290312
Iron chelators as therapeutic agents for the treatment of cancer.Q34671614
Novel targets of Akt, p21(Cipl/WAF1), and MDM2.Q34759285
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expressionQ35948212
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?Q35968417
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The Mad side of the Max network: antagonizing the function of Myc and more.Q36451356
The Myc oncoprotein as a therapeutic target for human cancerQ36578165
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and ApoptosisQ36651856
Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. Effects of gallium and dimethylsulfoxideQ36991500
The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma.Q37478093
The transferrin receptor: a key function in iron metabolismQ38702588
Transferrin receptors in human tissues: their distribution and possible clinical relevanceQ39510082
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexesQ39574223
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptakeQ39616081
AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell linesQ39907741
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteinsQ39959273
Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cellsQ40089058
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathwayQ40256045
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrestQ40702262
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesisQ43241094
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activityQ46670127
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)419
P577publication date2010-07-06
P1433published inBMC GenomicsQ15765854
P1476titleCausal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693
P478volume11

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