The C/EBP family of transcription factors in the liver and other organs

scientific article

The C/EBP family of transcription factors in the liver and other organs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2613.1998.00082.X
P8608Fatcat IDrelease_sf7afngkjbf6vo6uvgms73qt3m
P932PMC publication ID3220372
P698PubMed publication ID10319019

P2093author name stringTakiguchi M
P2860cites workFusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemiaQ24293329
Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activatorsQ24304434
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcomaQ24304506
The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localizationQ24308081
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10Q24308178
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcomaQ24309359
A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locusQ24318850
Derepression of the C/EBPα gene during adipogenesis: Identification of AP-2α as a repressorQ24319809
Isolation, characterization and chromosomal localization of the human GADD153 geneQ24337799
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta geneQ24532889
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6Q24563031
Interaction and functional collaboration of p300 and C/EBPβQ24644296
Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factorQ24647133
Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expressionQ42834946
Identification of a C/EBP-Rel complex in avian lymphoid cellsQ43182169
Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic developmentQ43456770
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domainQ43498366
The CCAAT/enhancer binding protein (C/EBP alpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBP beta) gene (CEBPB) maps to human chromosome 20q13.1.Q44896646
Role of the CCAAT/Enhancer Binding Protein-α Transcription Factor in the Glucocorticoid Stimulation of p21 Gene Promoter Activity in Growth-arrested Rat Hepatoma CellsQ46207190
Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe).Q48072084
A revised sequence of the rat c/ebp geneQ48083073
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in AplysiaQ48084060
slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C/EBPQ48153939
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork headQ48232472
LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator proteinQ48255574
Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birthQ52192519
Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding proteinQ52245350
Specification of C/EBP function during Drosophila development by the bZIP basic regionQ52512916
Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice.Q52532136
Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepressionQ53014939
Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP.Q54317767
Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional LevelsQ57033253
DNA-induced increase in the .alpha.-helical content of C/EBP and GCN4Q58450838
cAMP activation of CAAT enhancer-binding protein-beta gene expression and promoter I of acetyl-CoA carboxylaseQ38291510
The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycleQ38293198
Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the proteinQ38294158
Concerted participation of NF-kappa B and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liverQ38297326
Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor bindingQ38298189
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophagesQ38299607
Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, and delta genes in fully-differentiated 3T3-L1 adipocytesQ38299816
Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylationQ38307416
cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcriptionQ38333264
HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.Q38341812
Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemiaQ38342746
Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.Q38343717
The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cellsQ38359300
CCAAT box enhancer binding protein alpha (C/EBP-alpha) stimulates kappaB element-mediated transcription in transfected cellsQ38360591
Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 elementQ38361039
Design of a C/EBP-specific, dominant-negative bZIP protein with both inhibitory and gain-of-function properties.Q38362528
Functional organization of mammalian hexokinase II. Retention of catalytic and regulatory functions in both the NH2- and COOH-terminal halvesQ38362603
Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 geneQ40018438
Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcriptionQ40021186
CREB controls LAP/C/EBP beta transcriptionQ40022530
A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4.Q40396351
Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigenQ40396808
The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.Q40404777
High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factorsQ40406472
Transcriptional regulation of genes for ornithine cycle enzymesQ40941734
Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.Q41075231
Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression.Q41091114
Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin geneQ41187026
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) proteinQ41207724
Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytesQ41213220
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartiteQ41260447
Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP.Q41267086
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesisQ41291617
The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsivenessQ41351014
Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta geneQ41431621
Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factorsQ41431663
Expression of the gene encoding alpha 1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of beta and delta CCAAT-enhancer-binding proteinsQ41461319
Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoterQ41488600
Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell typesQ41558201
Reciprocal regulation of adipogenesis by Myc and C/EBP alphaQ41628463
Promoter and 11-kilobase upstream enhancer elements responsible for hepatoma cell-specific expression of the rat ornithine transcarbamylase geneQ41741681
Effect of dietary protein restriction on liver transcription factorsQ41834910
Activation of R-Ras by Ras-Guanine Nucleotide-releasing FactorQ42061965
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interactionQ42127094
Glucocorticoids Stimulate p21 Gene Expression by Targeting Multiple Transcriptional Elements within a Steroid Responsive Region of the p21 Promoter in Rat Hepatoma CellsQ42545445
Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβQ42546728
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domainQ42642911
CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.Q42801637
MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.Q42812855
Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytesQ42820575
Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factorsQ36665047
Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cellsQ36679250
Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interactionQ36689762
Regulation of the C/EBP-related gene gadd153 by glucose deprivationQ36694493
Lethal effect of the anti-Fas antibody in miceQ36696599
Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.Q36721547
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agentsQ36761728
Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition elementQ36769523
The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)Q36774167
In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificitiesQ36796830
Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in cultureQ36816759
Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preferenceQ36825593
An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP.Q36959311
Insulin is a prominent modulator of the cytokine-stimulated expression of acute-phase plasma protein genesQ36965573
CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytesQ37452845
CCAAT-enhancer binding protein: a component of a differentiation switchQ37624411
CCAAT/enhancer-binding proteins alpha and beta interact with the silencer element in the promoter of glutathione S-transferase P gene during hepatocarcinogenesisQ38287676
CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicingQ24682820
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGQ28118487
Calcium-regulated phosphorylation within the leucine zipper of C/EBP betaQ28209974
Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cellsQ28240503
A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOPQ28240554
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemiaQ28263998
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
Scissors-grip model for DNA recognition by a family of leucine zipper proteinsQ28272775
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cellsQ28276215
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP KinaseQ28280649
Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stressQ28281869
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptorQ28286827
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteinsQ28287408
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcriptionQ28287446
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitroQ28296697
The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4Q28297276
An essential role for C/EBPβ in female reproductionQ28507381
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteinsQ28509684
Isolation of a recombinant copy of the gene encoding C/EBPQ28565641
Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharideQ28568603
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control elementQ28570085
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBPQ28575310
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionallyQ28575328
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamilyQ28578854
CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentialsQ28579794
DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionallyQ28580942
Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alphaQ28591694
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8Q28609808
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6Q28609813
The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factorQ31076639
Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP familyQ33258850
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genesQ33577523
Alkylation interference identifies essential DNA contacts for sequence-specific binding of the eukaryotic transcription factor C/EBPQ33596869
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6Q33630682
Repression of transcription mediated by dual elements in the CCAAT/enhancer binding protein α geneQ33711879
Positive and negative regulatory elements in the mouse albumin enhancerQ33840270
Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alphaQ33874916
The transcription factor C/EBP-beta and its role in ovarian function; evidence for direct involvement in the ovulatory processQ33887360
Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1Q33995164
Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elementsQ34152141
Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.Q34313569
Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B.Q34328756
Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutationQ34365592
Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPsQ34409697
Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1Q34580109
Impaired Energy Homeostasis in C/EBPα Knockout MiceQ34662358
The 5' flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic miceQ34808387
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient miceQ35955690
Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3Q36185941
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elementsQ36311629
CCAAT/enhancer binding protein alpha (C/EBP alpha) undifferentiated protein: a developmentally regulated nuclear protein that binds to the C/EBP alpha gene promoterQ36462013
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoterQ36557608
Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase responseQ36559345
Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoidsQ36561243
Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140.Q36561393
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).Q36561426
Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cellsQ36562528
The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domainQ36567620
A Novel Transcriptional Regulatory Region within the Core Promoter of the Hepatocyte Growth Factor Gene Is Responsible for Its Inducibility by Cytokines via the C/EBP Family of Transcription FactorsQ36572989
Disruption of the c/ebpα Gene in Adult Mouse liverQ36573179
gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3Q36573685
CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn MiceQ36574127
A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activityQ36601870
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper regionQ36643268
A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factorQ36646897
P433issue6
P304page(s)369-391
P577publication date1998-12-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inInternational Journal of Experimental PathologyQ15750807
P1476titleThe C/EBP family of transcription factors in the liver and other organs
P478volume79

Reverse relations

cites work (P2860)
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