Hsp90 & Co. - a holding for folding

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Hsp90 & Co. - a holding for folding is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0968-0004(99)01373-0
P698PubMed publication ID10322418

P2093author name stringJ Buchner
P2860cites workIn vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysisQ22008008
Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptorQ24315622
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refoldingQ24562938
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformationQ24564127
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shockQ24648784
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agentQ27736012
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperoneQ27739168
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperoneQ27740876
hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperaturesQ27930675
Cdc37 is a molecular chaperone with specific functions in signal transductionQ27936846
Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependenceQ27937497
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperoneQ27937958
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1Q28118304
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformationQ28248831
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycinQ28277057
Hsp90 as a capacitor for morphological evolutionQ28290854
Steroid receptor interactions with heat shock protein and immunophilin chaperonesQ29619628
Hsp90 chaperones protein folding in vitro.Q30351360
Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsidsQ33885913
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivoQ33889333
Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivoQ34307813
The charged region of Hsp90 modulates the function of the N-terminal domainQ34988119
Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeastQ35938409
Ancient heat shock gene is dispensableQ36207033
Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunityQ36380745
Heat-shock protein hsp90 governs the activity of pp60v-src kinaseQ36449591
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agentQ36556311
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90Q37044062
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.Q37402942
Regulation of protein function through expression of chimaeric proteinsQ40535460
Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperonesQ40624749
A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.Q40794316
Dynamic activation of endothelial nitric oxide synthase by Hsp90.Q41044129
ATP-binding properties of human Hsp90.Q41098714
Chaperones get in touch: the Hip-Hop connectionQ41379488
Reduced levels of hsp90 compromise steroid receptor action in vivoQ45391521
Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.Q45975761
Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.Q52524930
Assessment of the ATP binding properties of Hsp90.Q54590056
Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independentQ63313318
Chaperone function of Hsp90-associated proteinsQ71824848
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23Q71824853
Trypanosoma cruzi heat-shock protein 90 can functionally complement yeastQ71965424
Interaction between casein kinase II and the 90-kDa stress protein, HSP90Q72344048
In vitro evidence that hsp90 contains two independent chaperone sitesQ73981312
Monomer arrangement in HSP90 dimer as determined by decoration with N and C-terminal region specific antibodiesQ77789674
Studies with Purified Chaperones Advance the Understanding of the Mechanism of Glucocorticoid Receptor-hsp90 Heterocomplex AssemblyQ81065585
P433issue4
P1104number of pages6
P304page(s)136-141
P577publication date1999-04-01
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleHsp90 & Co. - a holding for folding
P478volume24

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cites work (P2860)
Q44624987A Novel Binding Protein for a Member of CyP40-type Cyclophilins: N.crassa CyPBP37, a Growth and Thiamine Regulated Protein Homolog to Yeast Thi4p
Q34105936A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket
Q40040751A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.
Q44230449A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains
Q73977972A glucosinolate mutant of Arabidopsis is thermosensitive and defective in cytosolic Hsp90 expression after heat stress
Q33830135A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37.
Q35837624A molecular physiological review of vegetative desiccation tolerance in the resurrection plant Xerophyta viscosa (Baker)
Q34611485A novel method for detecting intramolecular coevolution: adding a further dimension to selective constraints analyses.
Q30856266A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast
Q40301279A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules
Q34433468A small heat shock protein is essential for thermotolerance and intracellular survival of Leishmania donovani
Q43577973A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
Q24541564A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins
Q28769077A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans
Q24543917A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase
Q22011182ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF
Q40364751Adaptor heat shock protein complex formation regulates trafficking of the asialoglycoprotein receptor
Q84924077Agonistic encounters and cellular angst: social interactions induce heat shock proteins in juvenile salmonid fish
Q24295270Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
Q40483613Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation
Q91613178Alcohol Modulates the Biogenesis and Composition of Microglia-Derived Exosomes
Q50515667Alpha-complemented beta-galactosidase. An in vivo model substrate for the molecular chaperone heat-shock protein 90 in yeast.
Q33969470Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.
Q46253811Analysis of HspB1 (Hsp27) Oligomerization and Phosphorylation Patterns and Its Interaction with Specific Client Polypeptides
Q33225270Analysis of hypoxia-inducible factor-1alpha accumulation and cell cycle in geldanamycin-treated human cervical carcinoma cells by laser scanning cytometry
Q38503421Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray
Q41623374Apo-Hsp90 coexists in two open conformational states in solution.
Q43289861Apoptosis caused by Hsp90 inhibitor geldanamycin in Leishmania donovani during promastigote-to-amastigote transformation stage
Q40424897Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2.
Q40592252Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway
Q34460136BAG-1 family of cochaperones in the modulation of nuclear receptor action.
Q38203487Barcoding heat shock proteins to human diseases: looking beyond the heat shock response
Q28216259Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain
Q51431702Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.
Q43572431Both the N- and C-terminal chaperone sites of Hsp90 participate in protein refolding
Q42743031Both the charged linker region and ATPase domain of Hsp90 are essential for Rad51-dependent DNA repair
Q28596567C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis
Q28271643C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances
Q35097617CHIP: a quality-control E3 ligase collaborating with molecular chaperones
Q28581892CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone
Q40763457CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.
Q44752936Calcineurin and heat-shock proteins modulation in clenbuterol-induced hypertrophied rat skeletal muscles
Q82685782Changes in the expression of heat-shock protein genes depending on different heat resistance of plants
Q38304970Chaperone network composition in Solanum lycopersicum explored by transcriptome profiling and microarray meta-analysis
Q27011776Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones
Q43028887Characterization of a novel complex from halophilic archaebacteria, which displays chaperone-like activities in vitro
Q44315461Characterization of a plant homolog of hop, a cochaperone of hsp90.
Q37308803Characterization of orchardgrass p23, a flowering plant Hsp90 cohort protein.
Q30679866Characterization of the cDNA encoding the 90 kDa heat-shock protein in the Lepidoptera Bombyx mori and Spodoptera frugiperda
Q34099877Characterizing heat shock protein 90 gene of Apolygus lucorum (Meyer-Dür) and its expression in response to different temperature and pesticide stresses
Q27938204Cns1 is an activator of the Ssa1 ATPase activity
Q24307587Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
Q92343830Comparative Proteomics and Physiological Analyses Reveal Important Maize Filling-Kernel Drought-Responsive Genes and Metabolic Pathways
Q33358679Comparison of good- and bad-quality cork: application of high-throughput sequencing of phellogenic tissue
Q27930200Contribution of N- and C-terminal domains to the function of Hsp90 in Saccharomyces cerevisiae
Q43664670Coordinated ATP hydrolysis by the Hsp90 dimer
Q27938998Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties
Q30993657DNA methylation, methyltransferases, and cancer
Q38297991DNA relaxation and cleavage assays to study topoisomerase I inhibitors
Q35096762Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.
Q40906095Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin
Q31108274Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
Q33281757Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas
Q33938836Differential proteomic analysis of grapevine leaves by iTRAQ reveals responses to heat stress and subsequent recovery
Q28484844Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment
Q35816373Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
Q44532388Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90.
Q73270311DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction
Q34088024Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy
Q28254233Drugging the cancer kinome: progress and challenges in developing personalized molecular cancer therapeutics
Q37489908Effect of geldanamycin on androgen receptor function and stability
Q40468950Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on pediatric acute lymphoblastic leukemia (ALL) with respect to Bcr-Abl status and imatinib mesylate sensitivity.
Q44106949Effects of glycyrrhizin on glucocorticoid signaling pathway in hepatocytes
Q34212832Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.
Q34009537Efficient detection of proteins retro-translocated from the ER to the cytosol by in vivo biotinylation.
Q34093483Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
Q36673389Endoplasmic reticulum chaperones are involved in the morphogenesis of rotavirus infectious particles
Q35188962Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents
Q28208008ErbB2 degradation mediated by the co-chaperone protein CHIP
Q44249797Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor
Q37490567Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans
Q33736465Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.
Q33948624Expression pattern of heat shock protein 90 gene of humphead snapper Lutjanus sanguineus during pathogenic Vibrio harveyi stress
Q28477776Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion
Q34980355FLT3 in human hematologic malignancies
Q38270187Folding and stability of the ligand-binding domain of the glucocorticoid receptor
Q34400939From the cradle to the grave: molecular chaperones that may choose between folding and degradation
Q24291221Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40
Q34545636Functional genomic approaches to understanding molecular chaperones and stress responses
Q31583023Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor
Q44616327G Protein-coupled Receptor Kinase Interaction with Hsp90 Mediates Kinase Maturation
Q30715432GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization
Q35929315Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway
Q33915513Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.
Q52128467Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity.
Q42878029Genetic engineering for heat tolerance in plants
Q42440163Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke
Q37596071Global transcriptome analysis of the heat shock response of Shewanella oneidensis
Q55514211Glutathione modulates the expression of heat shock proteins via the transcription factors BZIP10 and MYB21 in Arabidopsis.
Q42480755HEAT SHOCK PROTEIN 90C is a bona fide Hsp90 that interacts with plastidic HSP70B in Chlamydomonas reinhardtii
Q42883440HSF-1, HIF-1 and HSP90 expression on recombinant Pichia pastoris under fed-batch fermentation.
Q43852434HSP70 overexpression increases resistance of V79 cells to cytotoxicity of airborne pollutants, but does not protect the mitotic spindle against damage caused by airborne toxins.
Q92922007HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation
Q29617504HSP90 and the chaperoning of cancer
Q30373788Heat Shock Protein 90α Is a Potential Serological Biomarker of Acute Rejection after Renal Transplantation.
Q48331448Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi
Q39624638Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers.
Q38357729Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.
Q39230727Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani
Q22254677Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases
Q26776302Heat shock protein 90 targeting therapy: state of the art and future perspective
Q35038788Heat shock protein and proteasome targeting agents
Q28272905Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
Q35545091Heat shock proteins as emerging therapeutic targets
Q33899708Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
Q34382527Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors
Q36780484Hormetic modulation of aging and longevity by mild heat stress
Q33950214Host cell factor requirement for hepatitis C virus enzyme maturation
Q52575458Hsc70/Hsp40 chaperone system mediates the Hsp90-dependent refolding of firefly luciferase.
Q34012698Hsp104 interacts with Hsp90 cochaperones in respiring yeast
Q34545594Hsp70 chaperone machines.
Q24533332Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1
Q24596488Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor
Q29618584Hsp90 as a capacitor of phenotypic variation
Q36635195Hsp90 as a target for drug development
Q36581399Hsp90 at the crossroads of genetics and epigenetics
Q35640147Hsp90 can accommodate the simultaneous binding of the FKBP52 and HOP proteins
Q38310098Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains
Q42316572Hsp90 dependence of a kinase is determined by its conformational landscape
Q27934627Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore
Q42169358Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events
Q38895392Hsp90 inhibitors radicicol and geldanamycin have opposing effects on Leishmania Aha1-dependent proliferation.
Q30846862Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates
Q38482173Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).
Q28204780Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein
Q36041929Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells
Q34407370Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells
Q30838920Hsp90 regulation of fibroblast activation in pulmonary fibrosis
Q39304863Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
Q34138017Hsp90-binding immunophilins in plants: the protein movers
Q34473659Hsp90: a chaperone for protein folding and gene regulation
Q34319594Hsp90: chaperoning signal transduction
Q42477330HtpG is essential for the thermal stress management in cyanobacteria
Q34533865Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence
Q40920382Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction
Q40704635Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis
Q33422336Identification of differentially expressed genes in the growth plate of broiler chickens with thiram-induced tibial dyschondroplasia
Q90453929Identification of genes associated with stress tolerance in moth bean [Vigna aconitifolia (Jacq.) Marechal], a stress hardy crop
Q54039489IgA antibodies to the 27-kDa heat-shock protein in the genital tracts of women with gynecologic cancers.
Q54355782Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.
Q36690857Immunohistochemical detection of Hsp90 and Ki-67 in pterygium
Q24672548Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
Q33812161In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: posttranslational activation by Hsp90.
Q34327359In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins
Q40585096Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.
Q28212970Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization
Q73176009Insight into the secondary structure of non-native proteins bound to a molecular chaperone alpha-crystallin. An isotope-edited infrared spectroscopic study
Q73272057Interactions of Hsp90 with histones and related peptides
Q42802682Intracellular localization of the 90 kDA heat shock protein (HSP90α) determined by expression of a EGFP—HSP90α‐fusion protein in unstressed and heat stressed 3T3 cells
Q58459479Investigating Coral Reef Degradation at Alina's Reef in the Florida Keys: Cellular Physiology of White Grunt (Haemulon plumieri) as a Biological Indicator
Q38760723Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages
Q34338431Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin
Q77319142Isolation and quantification of the heat shock protein 90 alpha and beta isoforms from rat liver
Q43569162LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family
Q35725137Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest
Q30823415Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes
Q78203578Localization of calponin binding sites in the structure of 90 kDa heat shock protein (Hsp90)
Q43687948Localization of the chaperone domain of FKBP52.
Q34267286Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
Q51040073Low temperature or GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor and DnaK.
Q39974251MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei
Q34124519Maturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteins
Q40736227Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
Q28272747Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy
Q42670673MnHSP90 cDNA characterization and its expression during the ovary development in oriental river prawn, Macrobrachium nipponense.
Q36638210Molecular Characteristic, Protein Distribution and Potential Regulation of HSP90AA1 in the Anadromous Fish Coilia nasus
Q34038270Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins
Q36343046Molecular chaperones throughout the life cycle of the androgen receptor
Q34165962Molecular chaperones--cellular machines for protein folding
Q51263802Molecular chaperones: providing a safe place to weather a midlife protein-folding crisis.
Q42647966Molecular characterization and expression analysis of a heat shock protein 90 gene from disk abalone (Haliotis discus).
Q34470862Molecular characterization and expression of a heat shock protein gene (HSP90) from the carmine spider mite, Tetranychus cinnabarinus (Boisduval).
Q42634322Molecular cloning and expression analysis of a heat shock protein (Hsp90) gene from black tiger shrimp (Penaeus monodon).
Q38760108Molecular interactions of polo-like kinase 1 in human cancers.
Q41932080Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells.
Q73135768Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines
Q41828115Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole
Q39074963No stress--Hsp90 and signal transduction in Leishmania
Q34994676Nonrandom tripeptide sequence distributions at protein carboxyl termini
Q37320252Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket
Q40556496Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70.
Q33734537NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Q44126025Overexpression of the wheat FK506-binding protein 73 (FKBP73) and the heat-induced wheat FKBP77 in transgenic wheat reveals different functions of the two isoforms
Q44242668Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis.
Q37288545Pathology-dependent effects linked to small heat shock proteins expression: an update
Q39510533Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells
Q34380573Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration
Q28214608Phosphorylation and hsp90 binding mediate heat shock stabilization of p53
Q24294328Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding
Q44094456Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones
Q33923929Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.
Q37532027Posttranslational modulation on the biological activities of molecular chaperones
Q33834707Production and purification of human Hsp90β in Escherichia coli
Q38509921Profiling neuroendocrine gene expression changes following fadrozole-induced estrogen decline in the female goldfish
Q39384090Protein SUMOylation and plant abiotic stress signaling: in silico case study of rice RLKs, heat-shock and Ca(2+)-binding proteins
Q34293903Protein translocation across membranes
Q36974914Protein transport across the parasitophorous vacuole of Plasmodium falciparum: into the great wide open
Q37383489Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import.
Q43156161Quality control of a cytoplasmic protein complex: chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast
Q28578339Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex
Q28209725Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90
Q41808075Rapid decrease of CD16 (FcγRIII) expression on heat-shocked neutrophils and their recognition by macrophages
Q34141716Recognition between flexible protein molecules: induced and assisted folding
Q44217992Redox control of Hsp70-Co-chaperone interaction revealed by expression of a thioredoxin-like Arabidopsis protein
Q30368774Reducing the false positive rate in the non-parametric analysis of molecular coevolution.
Q38524259Regulation of protein activity with small-molecule-controlled inteins
Q33713035Regulation of survivin function by Hsp90
Q40832327Regulation of the atrial natriuretic peptide receptor by heat shock protein 90 complexes
Q38297618Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substrates
Q39645245Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability
Q33701406Retraction: Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation
Q40734779Role of p50/CDC37 in hepadnavirus assembly and replication
Q39521915Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides
Q60017544Roles of heat shock factor 1 beyond the heat shock response
Q33336944SHEPHERD is the Arabidopsis GRP94 responsible for the formation of functional CLAVATA proteins
Q33906867Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.
Q43559891Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily
Q27931140Sti1 Is a Novel Activator of the Ssa Proteins
Q33334155Stress genes and proteins in the archaea
Q73408466Structural/functional assignment of unknown bacteriophage T4 proteins by iterative database searches
Q27652939Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1
Q27622332Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
Q34116190Structure, function, and mechanism of the Hsp90 molecular chaperone
Q31053524Study of therapy resistance in cancer cells with functional proteome analysis
Q36843657Substrate protein folds while it is bound to the ATP-independent chaperone Spy
Q35375097Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin
Q79236261Synthesis of novel fluorescent probes for the molecular chaperone Hsp90
Q34662543T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis
Q34330916Targeting telomeres and telomerase
Q39767891Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives.
Q43166064The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress.
Q42645780The ATPase cycle of the mitochondrial Hsp90 analog Trap1.
Q51042630The HSP90 chaperone machinery.
Q24535594The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR
Q34159497The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically
Q28361507The Hsp90 family of proteins in Arabidopsis thaliana
Q36845743The Hsp90-Sti1 interaction is critical for Leishmania donovani proliferation in both life cycle stages
Q39992486The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex
Q36982944The activities and function of molecular chaperones in the endoplasmic reticulum
Q43180721The balance of Polo-like kinase 1 in tumorigenesis
Q50493069The chlorate-resistant and photomorphogenesis-defective mutant cr88 encodes a chloroplast-targeted HSP90.
Q34861540The co-chaperone SGT of Leishmania donovani is essential for the parasite's viability
Q24652993The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor
Q39927053The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity
Q48086976The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth
Q34966136The heat shock response and cytoprotection of the intestinal epithelium
Q24550978The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor
Q40025733The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly
Q34814876The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development
Q38212658The many functions of the endoplasmic reticulum chaperones and folding enzymes
Q73422790The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest
Q44295200The oligomeric state, complex formation, and chaperoning activity of hsp70 and hsp80 of Neurospora crassa
Q33967931The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
Q33723746The role of HSP90 in evolution
Q34688320The role of chaperones in polyglutamine disease
Q38033199The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.
Q34280951The role of heat shock proteins and their receptors in the activation of the immune system
Q33371122The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability
Q33637496The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone
Q38268859The virus-induced HSPs regulate the apoptosis of operatus APCs that result in autoimmunity, not in homeostasis
Q36501370Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease
Q73462103Three-step chromatographic purification of Cpr6, a cyclophilin from Saccharomyces cerevisiae
Q47900347Tic40, a new "old" subunit of the chloroplast protein import translocon
Q39538968Transcriptional analysis of major heat shock genes of Helicobacter pylori
Q92404538Transcriptomic analysis reveals recovery strategies in strawberry roots after using a soil amendment in continuous cropping soil
Q53691564Transcriptomic study to understand thermal adaptation in a high temperature-tolerant strain of Pyropia haitanensis.
Q52678882Troglitazone induces differentiation in Trypanosoma brucei.
Q39987469Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.
Q36370830Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing
Q28586476Unc45 activates Hsp90-dependent folding of the myosin motor domain
Q28588643Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain
Q28080885Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis
Q34348757Unfolding the role of chaperones and chaperonins in human disease
Q44504087Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.
Q33955890Vegetative incompatibility in filamentous fungi: a roundabout way of understanding the phenomenon.
Q24317168XAP2 inhibits glucocorticoid receptor activity in mammalian cells
Q40774867c-Src and HSP72 interact in ATP-depleted renal epithelial cells.
Q48082512cDNA cloning, heat shock regulation and developmental expression of the hsp83 gene in the Mediterranean fruit fly Ceratitis capitata.
Q52599768p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families.

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