Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase

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Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...511662S
P356DOI10.1371/JOURNAL.PONE.0011662
P932PMC publication ID2906514
P698PubMed publication ID20657842
P5875ResearchGate publication ID45288727

P50authorBin ShanQ42738140
P2093author name stringYing Zhuo
James S Hagood
Joseph A Lasky
Mark MacEwen
Hong T Nguyen
Gilbert F Morris
P2860cites workDifferential expression, surface binding, and response to connective tissue growth factor in lung fibroblast subpopulationsQ49164455
Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHCQ69378718
Thy1 (+) and (-) lung fibrosis subpopulations in LEW and F344 ratsQ71687594
Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expressionQ73923154
Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cellsQ79450896
TH1/TH2 immune response in lung fibroblasts in interstitial lung diseaseQ81364111
Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activityQ24337206
SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingQ24551043
Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosisQ28245613
Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep IQ28570478
Differential expression of platelet-derived growth factor-alpha receptor by Thy-1(-) and Thy-1(+) lung fibroblastsQ28573176
Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiationQ28580247
Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoproteinQ31909318
Proinflammatory cytokinesQ33913139
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.Q34198891
Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrateQ34428217
Loss of fibroblast Thy-1 expression correlates with lung fibrogenesisQ35085070
Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuliQ35103031
Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responsesQ35610005
Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanismQ36229873
Concordant and discordant interleukin-1-mediated signaling in lung fibroblast thy-1 subpopulationsQ38288822
Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53.Q38329200
Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cellsQ40495577
Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathwayQ40510606
Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.Q41017734
Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsetsQ41155023
Differential expression of interleukin 1 alpha by Thy-1+ and Thy-1- lung fibroblast subpopulations: enhancement of interleukin 1 alpha production by tumor necrosis factor-alphaQ41175169
Fibroblast heterogeneity in the periodontium and other tissuesQ41402269
Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressorQ42528827
Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypesQ43867818
Differential COX localization and PG release in Thy-1(+) and Thy-1(-) human female reproductive tract fibroblastsQ44054995
c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expressionQ44367846
Tyrosine Phosphorylation of I-κB Kinase α/β by Protein Kinase C-Dependent c-Src Activation Is Involved in TNF-α-Induced Cyclooxygenase-2 ExpressionQ44411492
Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblastsQ46442217
Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activationQ47915483
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e11662
P577publication date2010-07-19
P1433published inPLOS OneQ564954
P1476titleThy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase
P478volume5

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cites work (P2860)
Q39541274Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts
Q37672479Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures
Q41896223Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression.
Q35470183Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells
Q37295341Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation
Q36499388Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis
Q40691949HDAC is essential for epigenetic regulation of Thy-1 gene expression during LPS/TLR4-mediated proliferation of lung fibroblasts
Q47137189Induction of a novel isoform of the lncRNA HOTAIR in Claudin-low breast cancer cells attached to extracellular matrix
Q30625242Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen
Q33551808Interaction of Src and Alpha-V Integrin Regulates Fibroblast Migration and Modulates Lung Fibrosis in A Preclinical Model of Lung Fibrosis
Q42234172Predisposition for disrepair in the aged lung
Q35080815Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells
Q36767279Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture.
Q34186283Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis
Q35576492Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn

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