Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.

scientific article published on August 1998

Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1165/AJRCMB.19.2.3149
P698PubMed publication ID9698598

P2093author name stringJ M Stark
K Wernke-Dollries
M A Fiedler
P2860cites workTranscription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8Q28609808
Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa BQ28615800
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa BQ29618210
Structure, regulation and function of NF-kappa BQ29620225
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cellsQ34017706
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitorQ35606533
Control of gene expression by proteolysisQ41066929
Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns.Q46011333
Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortalityQ46143166
P433issue2
P921main subjectNF-κBQ411114
P304page(s)259-268
P577publication date1998-08-01
P1433published inAmerican Journal of Respiratory Cell and Molecular BiologyQ4744268
P1476titleInhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.
P478volume19

Reverse relations

cites work (P2860)
Q44555573A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives
Q34485252A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB.
Q44029855Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils
Q92697845Adenovirus early region 3 RIDα protein limits NFκB signaling through stress-activated EGF receptors
Q33883632Advances in immunopharmacology of asthma
Q40228709Amino acids 1 to 422 of the spike protein of SARS associated coronavirus are required for induction of cyclooxygenase-2.
Q40611970Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta
Q35743287Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy
Q37190216Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells.
Q34079481Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
Q35079054Clinical applications of cytokine assays.
Q92244206Clockophagy is a novel selective autophagy process favoring ferroptosis
Q47225624Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
Q40705828Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation
Q58450597Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells
Q44271884Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation
Q40521090Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line
Q42492799Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells
Q43687794Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium.
Q28270149Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action
Q28181056Impact of CFTR DeltaF508 mutation on prostaglandin E2 production and type IIA phospholipase A2 expression by pulmonary epithelial cells
Q39551312Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells
Q43796609Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway
Q40622954Inhibition of proteasome function leads to NF-κB-independent IL-8 expression in human hepatocytes
Q40587558Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding
Q44009221Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells
Q90002498Interplay of Autophagy Inducer Rapamycin and Proteasome Inhibitor MG132 in Reduction of Foam Cell Formation and Inflammatory Cytokine Expression
Q34687385Intracellular signal transduction in eosinophils and its clinical significance
Q34038263MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB
Q28505699MEF2C mediates the activation induced cell death (AICD) of macrophages
Q42142390Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation
Q33425909NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
Q44391415NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury
Q41898941Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation.
Q44020836Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells
Q35789327Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis
Q39978747Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.
Q48480824Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAM in adult rat brain
Q37250219Proteasome inhibitor MG-132 induces MCPIP1 expression
Q40812334Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts
Q35842184Regulation of gap junctional communication by a pro-inflammatory cytokine in cystic fibrosis transmembrane conductance regulator-expressing but not cystic fibrosis airway cells.
Q42525871Regulation of human airway epithelial cell IL-8 expression by MAP kinases
Q21093328Respiratory syncytial virus and TNF alpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappa B1
Q39321350Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Q42115226SUMOylation of HNF4α regulates protein stability and hepatocyte function
Q37303197Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway
Q33996632Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages
Q45328083Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions.
Q43568777Suppression of lung inflammation in rats by prevention of NF-kappaB activation in the liver
Q43263715TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways
Q55259593The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.
Q51465407The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.
Q42234561The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity.
Q39686446The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state
Q33993411The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
Q34102964The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies
Q42048854The role of p53 in bleomycin-induced DNA damage in the lung. A comparative study with the small intestine
Q33640356Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase
Q40816417Tumor necrosis factor-alpha inhibits aquaporin 5 expression in mouse lung epithelial cells.
Q51568269Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.
Q40671379Tumour necrosis factor-alpha-induced expression of intercellular adhesion molecule-1 on human eosinophilic leukaemia EoL-1 cells is mediated by the activation of nuclear factor-kappaB pathway
Q35621527VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
Q39715817Vitamin D does not modulate NF-kappaB activity in Jurkat T cells

Search more.