Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells.

scientific article published on 13 March 2009

Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPLUNG.90516.2008
P932PMC publication ID2681348
P698PubMed publication ID19286927
P5875ResearchGate publication ID24201466

P50authorThomas P ShanleyQ56983000
P2093author name stringLei Sun
Vania Hinkovska-Galcheva
Marc B Hershenson
Qing Cai
Timothy T Cornell
Susan Vanway
P2860cites workPositive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2AQ24318289
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBQ24321775
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNAQ24336740
High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndromeQ24657096
Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthmaQ28343337
The acute respiratory distress syndromeQ29615140
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.Q33860531
Neutrophils and acute lung injuryQ33965359
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanismsQ35750001
Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lungQ35817557
The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cellsQ35842874
Prognostic determinants of acute respiratory distress syndrome in adults: impact on clinical trial designQ36064712
Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shockQ36889928
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survivalQ37015135
Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndromeQ37080116
Activation and localization of transcription factor, nuclear factor-kappaB, in asthmaQ38331366
Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathwaysQ39448079
PP2A regulates upstream members of the c-jun N-terminal kinase mitogen-activated protein kinase signaling pathwayQ40095106
Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinaseQ40255246
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant NacystelynQ40557413
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cellsQ40778942
Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A.Q40857568
Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.Q41017734
Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activationQ41105089
Signal transduction of stress via ceramideQ41841345
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acidQ42474499
Regulation of human airway epithelial cell IL-8 expression by MAP kinasesQ42525871
The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling.Q43516344
A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophilsQ44108466
Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responsesQ44289470
Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemiaQ44323782
Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophilsQ44551602
Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK.Q45021756
Quantitative measurement of sn-1,2-diacylglycerolsQ45205999
Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortalityQ46143166
Purification and characterization of ceramide-activated protein phosphatasesQ47710075
Ceramide activates heterotrimeric protein phosphatase 2A.Q48246807
Ceramide quantitation: evaluation of a mixed micellar assay using E. coli diacylglycerol kinaseQ54613087
Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy.Q54637647
c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells.Q64967336
Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS) and patients at risk for ARDSQ67476176
Structural alterations of lung parenchyma in the adult respiratory distress syndromeQ70334896
Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsisQ71513143
Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sitesQ71942145
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transductionQ72068815
Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groupsQ72212878
The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulationQ73119557
Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbits by a monoclonal antibody to IL-8Q73273519
Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: mortality prognostic studyQ73430271
P433issue5
P921main subjectceramidesQ424213
P304page(s)L849-56
P577publication date2009-03-13
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleCeramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells
P478volume296

Reverse relations

cites work (P2860)
Q36336086An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes
Q35617207Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin
Q39002081Calcium phosphate particles induce interleukin-8 expression in a human gingival epithelial cell line via the nuclear factor-κB signaling pathway
Q42005356Ceramide in cystic fibrosis: a potential new target for therapeutic intervention
Q38916731Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses
Q39229980EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.
Q40065213Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.
Q36238296Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide.
Q38821886Intratracheal myriocin enhances allergen-induced Th2 inflammation and airway hyper-responsiveness
Q40441605Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge.
Q36050039Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Q38792743Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells
Q38734326Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury.
Q92489253Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
Q38914089Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-α.
Q48192654Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion.
Q26771956Role of Sphingolipids in the Pathobiology of Lung Inflammation
Q36919811Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling
Q38895246TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes
Q61797807TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis
Q43851423The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Q40104108The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection.
Q37416615The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells
Q37928817The role of sphingolipids in respiratory disease
Q51573670Theophylline Represses IL-8 Secretion from Airway Smooth Muscle Cells Independently of Phosphodiesterase Inhibition. Novel Role as a Protein Phosphatase 2A Activator.
Q54318382Time-course analysis of injured skeletal muscle suggests a critical involvement of ERK1/2 signaling in the acute inflammatory response.
Q35011972ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution