| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Wenpeng Cui | Q87744404 |
| Ping Luo | Q91586811 | ||
| Bing Du | Q96194718 | ||
| P2093 | author name string | Xiaohong Xu | |
| Xu Min | |||
| P2860 | cites work | Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 |
| Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region | Q24563505 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration | Q24644214 | ||
| Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease | Q26741451 | ||
| NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer | Q26747249 | ||
| Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention | Q26778356 | ||
| Effect of redox modulating NRF2 activators on chronic kidney disease | Q26827726 | ||
| Epigenetic regulation of Keap1-Nrf2 signaling | Q28084220 | ||
| Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents | Q28085561 | ||
| Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription | Q28202594 | ||
| The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm | Q28216217 | ||
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Q28218883 | ||
| Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. | Q39193275 | ||
| Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance | Q39217937 | ||
| The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. | Q39384159 | ||
| The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial | Q39437861 | ||
| Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. | Q39501191 | ||
| A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. | Q39710585 | ||
| High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway | Q40340196 | ||
| Nuclear import and export signals in control of Nrf2. | Q40420771 | ||
| Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice | Q40895409 | ||
| Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model | Q41856390 | ||
| Validation of the multiple sensor mechanism of the Keap1-Nrf2 system | Q41962064 | ||
| Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis | Q42250365 | ||
| Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury | Q42383171 | ||
| Resveratrol attenuates early diabetic nephropathy by down-regulating glutathione s-transferases Mu in diabetic rats. | Q42710707 | ||
| Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling | Q42744612 | ||
| Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation | Q43095387 | ||
| Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects | Q43475358 | ||
| Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats | Q43996148 | ||
| Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium | Q44222495 | ||
| Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells | Q44818600 | ||
| Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice | Q45775555 | ||
| Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats | Q46046845 | ||
| Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells | Q46174889 | ||
| Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. | Q46193503 | ||
| Effect of resveratrol and rosuvastatin on experimental diabetic nephropathy in rats | Q46494161 | ||
| Rutin Prevents High Glucose-Induced Renal Glomerular Endothelial Hyperpermeability by Inhibiting the ROS/Rhoa/ROCK Signaling Pathway | Q46498226 | ||
| CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells | Q46507598 | ||
| Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain. | Q46515742 | ||
| Sinomenine alleviates high glucose-induced renal glomerular endothelial hyperpermeability by inhibiting the activation of RhoA/ROCK signaling pathway | Q46523089 | ||
| Ursodeoxycholic Acid Ameliorated Diabetic Nephropathy by Attenuating Hyperglycemia-Mediated Oxidative Stress | Q46546488 | ||
| Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome | Q46574591 | ||
| Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2. | Q46669906 | ||
| Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease. | Q46771203 | ||
| Activation of the Nrf2-ARE pathway attenuates hyperglycemia-mediated injuries in mouse podocytes | Q46841761 | ||
| Nrf2 ameliorates diabetic nephropathy progression by transcriptional repression of TGFβ1 through interactions with c-Jun and SP1. | Q46863656 | ||
| Zinc modulates high glucose-induced apoptosis by suppressing oxidative stress in renal tubular epithelial cells | Q46924511 | ||
| Angiotensin II type 1 receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy | Q46966465 | ||
| Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease | Q36302209 | ||
| Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. | Q36410781 | ||
| Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet | Q36427702 | ||
| Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy | Q36446790 | ||
| Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy | Q36707919 | ||
| Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury | Q36711841 | ||
| Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease | Q36788430 | ||
| Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. | Q36796876 | ||
| Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling | Q36994823 | ||
| Oxidative Stress in Diabetic Nephropathy | Q37003803 | ||
| The extinguished BEACON of bardoxolone: not a Monday morning quarterback story | Q37050229 | ||
| Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice | Q37210162 | ||
| Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. | Q37214176 | ||
| Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding | Q37231144 | ||
| Genetic variants of nuclear factor erythroid-derived 2-like 2 associated with the complications in Han descents with type 2 diabetes mellitus of Northeast China | Q37370799 | ||
| Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity | Q37419174 | ||
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer | Q37423465 | ||
| C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21 | Q37603152 | ||
| Discovery of the negative regulator of Nrf2, Keap1: a historical overview | Q37743470 | ||
| Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and "cryptic targets" of transcription factors | Q38024881 | ||
| Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology? | Q38088948 | ||
| Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis | Q38123599 | ||
| Oxidative stress: meeting multiple targets in pathogenesis of diabetic nephropathy | Q38198142 | ||
| Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway. | Q38228436 | ||
| Diabetic nephropathy: where are we on the journey from pathophysiology to treatment? | Q38560762 | ||
| Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. | Q38822665 | ||
| The Dual Roles of NRF2 in Cancer. | Q38855289 | ||
| Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1. | Q38893068 | ||
| Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells | Q38942751 | ||
| The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2. | Q38984911 | ||
| Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice | Q39070432 | ||
| Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl | Q39114823 | ||
| RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. | Q39161771 | ||
| NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway. | Q51067070 | ||
| Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. | Q51352249 | ||
| Renoprotective effect of Bacopa monnieri via inhibition of advanced glycation end products and oxidative stress in STZ-nicotinamide-induced diabetic nephropathy. | Q51361535 | ||
| The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial. | Q51487094 | ||
| Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. | Q51593952 | ||
| Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. | Q53183054 | ||
| Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway. | Q54287779 | ||
| Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. | Q54497843 | ||
| Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease | Q59284849 | ||
| Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1 | Q83153571 | ||
| The Keap1-Nrf2 system as an in vivo sensor for electrophiles | Q83563984 | ||
| Attenuation of glomerular injury in diabetic mice with tert-butylhydroquinone through nuclear factor erythroid 2-related factor 2-dependent antioxidant gene activation | Q83575106 | ||
| Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD | Q83917014 | ||
| HGF-mediated inhibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells | Q84359795 | ||
| Protein modification as oxidative stress marker in normal and pathological human seminal plasma | Q84549032 | ||
| Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells | Q85258055 | ||
| A new classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy | Q86360257 | ||
| The role of DJ-1/Nrf2 pathway in the pathogenesis of diabetic nephropathy in rats | Q86867258 | ||
| Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies | Q87117796 | ||
| Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats | Q89310384 | ||
| An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements | Q28244853 | ||
| Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron | Q28261724 | ||
| Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β | Q28383951 | ||
| Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes | Q28387207 | ||
| Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy | Q28391260 | ||
| Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription | Q28395088 | ||
| Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2 | Q28396790 | ||
| Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model | Q28910182 | ||
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers | Q29616503 | ||
| Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription | Q29617066 | ||
| Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction | Q29617574 | ||
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation | Q29618051 | ||
| Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature | Q30422206 | ||
| Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. | Q33733198 | ||
| The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy | Q33750711 | ||
| Small molecule modulators of antioxidant response pathway | Q33782967 | ||
| Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene | Q33811991 | ||
| Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition | Q33991666 | ||
| MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism | Q34189586 | ||
| Bardoxolone methyl and kidney function in CKD with type 2 diabetes | Q34194954 | ||
| Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice. | Q34227889 | ||
| Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases | Q34252986 | ||
| A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas | Q34277465 | ||
| Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter | Q34278223 | ||
| Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease | Q34383685 | ||
| Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl | Q34423200 | ||
| Novel equations to estimate lean body mass in maintenance hemodialysis patients | Q34518515 | ||
| Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy | Q35404877 | ||
| miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells | Q35562532 | ||
| Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles | Q35757035 | ||
| Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target | Q35880186 | ||
| Therapeutic potential of digitoflavone on diabetic nephropathy: nuclear factor erythroid 2-related factor 2-dependent anti-oxidant and anti-inflammatory effect | Q35884405 | ||
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome | Q35974394 | ||
| Role of oxidative stress in diabetic nephropathy | Q36094470 | ||
| Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation | Q36289400 | ||
| Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. | Q36293645 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | nuclear factor erythroid 2-related factor 2 | Q24788604 |
| diabetic nephropathy | Q1129105 | ||
| DNA-binding protein | Q2252764 | ||
| response elements | Q7315962 | ||
| transcription factor | Q407384 | ||
| oxidative stress | Q898814 | ||
| physiological phenomenon | Q66615932 | ||
| P304 | page(s) | 3797802 | |
| P577 | publication date | 2017-04-23 | |
| P1433 | published in | Journal of Diabetes Research | Q26841822 |
| P1476 | title | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy | |
| P478 | volume | 2017 |
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