Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice

scientific article published on 12 August 2016

Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS17081327
P932PMC publication ID5000724
P698PubMed publication ID27529235

P2093author name stringYan Jiang
Wei Liang
Xiuli Zhang
Dan Liang
Hui He
Zhi-Hong Chi
Jianfei Ma
P2860cites workExpression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition.Q52189547
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Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular diseaseQ39960465
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Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expressionQ42158636
Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in miceQ42165757
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A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.Q42486098
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Resveratrol ameliorates early diabetic nephropathy associated with suppression of augmented TGF-β/smad and ERK1/2 signaling in streptozotocin-induced diabetic ratsQ42752177
Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice.Q42936581
Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injuryQ43071829
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failureQ43223381
Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosisQ43963197
Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathwayQ44036628
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.Q44773514
The transcription factor NRF2 protects against pulmonary fibrosisQ44945397
Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosisQ45235054
Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose conditionQ46163975
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.Q46193503
Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signalingQ46480430
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factorsQ46921370
Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease.Q47586979
Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humansQ47957732
TGF-beta signal transductionQ22003891
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytesQ24170228
The pathogenic role of the renal proximal tubular cell in diabetic nephropathyQ27021593
Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)Q28366662
Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathwayQ28573256
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretionQ28578447
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathyQ33750711
The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?Q33778918
Bardoxolone methyl and kidney function in CKD with type 2 diabetesQ34194954
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.Q34214639
Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy modelsQ34399505
Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signalingQ34441024
Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injuryQ34572978
Combating diabetic nephropathy with drug therapyQ35087369
Reactive oxygen species and matrix remodeling in diabetic kidneyQ35182366
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathyQ35404877
Retracted: Berberine Improves Kidney Function in Diabetic Mice via AMPK ActivationQ35436194
Insights into the mechanisms of renal fibrosis: is it possible to achieve regression?Q36188436
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosisQ36652097
Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathwaysQ36690275
Phenotypic transitions and fibrosis in diabetic nephropathyQ36753326
Rodent models of streptozotocin-induced diabetic nephropathyQ36820026
Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosisQ36842403
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked miceQ37513209
TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy.Q37627056
Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cellsQ38887463
Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathwayQ39048243
Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth.Q39108936
Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cellsQ39370584
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signalingQ39431057
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P577publication date2016-08-12
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleProtective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice
P478volume17

Reverse relations

cites work (P2860)
Q64093257Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
Q55108878Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway.
Q33819605Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities
Q37741992Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
Q59125948Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys
Q48096965Modulation of heme oxygenase-1 expression and activity affects streptozotocin-induced diabetic nephropathy in rats.
Q92869440Nrf2 signaling attenuates epithelial-to-mesenchymal transition and renal interstitial fibrosis via PI3K/Akt signaling pathways
Q91595151Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice
Q92510491Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review
Q33645497Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
Q94950021Therapeutic Application of Nutraceuticals in Diabetic Nephropathy: Current Evidence and Future Implications
Q60932209Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice

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