Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator

scientific article published on October 1995

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.2337/DIAB.44.10.1139
P698PubMed publication ID7556948

P2093author name stringZiyadeh FN
Sharma K
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecthyperglycemiaQ271993
P1104number of pages8
P304page(s)1139-1146
P577publication date1995-10-01
P1433published inDiabetesQ895262
P1476titleHyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
P478volume44

Reverse relations

cites work (P2860)
Q28535969'Special k' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine
Q423785856. Diabetic Nephropathy
Q59809890A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy
Q92535726A Significant Association Between Rhein and Diabetic Nephropathy in Animals: A Systematic Review and Meta-Analysis
Q30355733A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease.
Q35915947A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells
Q44313580ACE-I and ARBs in early diabetic nephropathy
Q58612380Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Q36352141Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy
Q42641988Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice
Q57649328Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats
Q47790063Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney
Q43931414Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells
Q40789629Advanced glycation end products (AGEs)-induced expression of TGF-beta 1 is suppressed by a protease in the tubule cell line LLC-PK1.
Q52609089Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-β and vascular endothelial growth factor (VEGF) by pericytes.
Q44367135Amino acids induce indicators of response to injury in glomerular mesangial cells
Q40193234An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells
Q40560353An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy.
Q34075013Angiogenesis and chronic kidney disease
Q39324415Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa Oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats.
Q35585339Association of Transforming Growth Factor Beta-1 (TGF-β1) Genetic Variation with Type 2 Diabetes and End Stage Renal Disease in Two Large Population Samples from North India
Q44686981Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model
Q35874334Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1.
Q39224484C-Peptide and its intracellular signaling
Q39903991C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy
Q73181271Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients
Q37335279Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Q37369666Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
Q35306426Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice
Q35973844Circulating TGF-β1-Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes
Q37392107Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?
Q35050392Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease
Q43134093Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.
Q37110641DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.
Q36095577Decorin deficiency enhances progressive nephropathy in diabetic mice.
Q22254569Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
Q47964840Detection of serum collagen type IV in children with type 1 (insulin-dependent) diabetes mellitus--a longitudinal study
Q35560878Development of Diabetes Mellitus Several Years after Manifestation of Diabetic Nephropathy: Case Report and Review of Literature
Q38227252Diabetic nephropathy--emerging epigenetic mechanisms
Q34733351Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.
Q48569238Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes
Q28582870Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response
Q47343602Effect of the Administration of Solanum nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats
Q35007388Effects of Allium victorialis leaf extracts and its single compounds on aldose reductase, advanced glycation end products and TGF-β1 expression in mesangial cells
Q35546208Effects of Epigallocatechin-3-Gallate on the Expression of TGF-β1, PKC α/βII, and NF-κB in High-Glucose-Stimulated Glomerular Epithelial Cells.
Q36844506Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
Q43207567Effects of genistein on secretion of extracellular matrix components and transforming growth factor beta in high-glucose-cultured rat mesangial cells
Q37232679Effects of glucagon-like peptide-1 receptor agonists on renal function
Q33792658Effects of vitamin D combined with pioglitazone hydrochloride on bone mineral density and bone metabolism in Type 2 diabetic nephropathy
Q37379205Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice
Q36437819Elevated expression of transforming growth factor-beta in adipose tissue from obese mice
Q46107711Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway
Q34986508Epigenetic mechanisms in diabetic vascular complications
Q92512595Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
Q34257934Exacerbation of diabetic renal alterations in mice lacking vasohibin-1.
Q37311890FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy.
Q51759559Fenofibrate attenuates diabetic nephropathy in experimental diabetic rat's model via suppression of augmented TGF-β1/Smad3 signaling pathway.
Q24644869Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers
Q34648147Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1.
Q30422127Gene expression differences in skin fibroblasts in identical twins discordant for type 1 diabetes
Q46790834Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli
Q39604870Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
Q33840481Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells
Q40296112Glucose enhances mesangial cell apoptosis
Q80387303Glucose modulates handling of apoptotic cells by mesangial cells: involvement of TGF-beta1
Q35745848Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1.
Q78115905Growth factors VEGF and TGF-beta1 in peritoneal dialysis
Q38189884Have we reached the limits for the treatment of diabetic nephropathy?
Q40853703Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C.
Q40626188Hexosamines and TGF-β1use similar signaling pathways to mediate matrix protein synthesis in mesangial cells
Q31126617High glucose and endothelial cell growth: novel effects independent of autocrine TGF-beta 1 and hyperosmolarity
Q28119012High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells
Q28359749High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases
Q39796701High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
Q42347019Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats
Q36116999Hyperglycemia: its imminent effects on mammalian nephrogenesis.
Q36780416Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
Q37342029Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis
Q39473211ID1 inhibits USF2 and blocks TGF-β-induced apoptosis in mesangial cells
Q90400326Identification of key genes and pathways in diabetic nephropathy by bioinformatics analysis
Q51869814Induction of hyperglycemia in adult intrauterine growth-restricted rats: effects on renal function.
Q36117573Inflammatory cytokines as predictive markers for early detection and progression of diabetic nephropathy
Q37319338Inhibiting Amadori-modified albumin formation improves biomarkers of podocyte damage in diabetic rats
Q35804221Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
Q36366915Inhibition of NA(+)/H(+) Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats
Q53151512Inhibition of the expression of TGF-β1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist.
Q40876230Inhibition of type I and III IP(3)Rs by TGF-beta is associated with impaired calcium release in mesangial cells
Q26852400Inhibitors/antagonists of TGF-β system in kidney fibrosis
Q34784162Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression
Q36699878Involvement of p300/CBP and epigenetic histone acetylation in TGF-β1-mediated gene transcription in mesangial cells
Q42913254Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy
Q46654427Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats
Q97646291Mechanisms of Herbal Nephroprotection in diabetes mellitus
Q35299817Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways
Q36124250MicroRNA circuits in transforming growth factor-β actions and diabetic nephropathy.
Q35652362MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.
Q36094855MicroRNAs and diabetic complications
Q35907222MicroRNAs and the glomerulus
Q37258870MicroRNAs and their role in progressive kidney diseases
Q36166755MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets
Q37146727MicroRNAs: potential mediators and biomarkers of diabetic complications.
Q28354033Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases
Q37243359Molecular medicine of microRNAs: structure, function and implications for diabetes.
Q37092968Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Q50053973Nephroprotective effects of diacylglycerol on diabetic nephropathy in type 2 diabetic rats
Q58246147Nephroprotective potential ofQuercus infectoriagalls against experimentally induced diabetic nephropathy in rats through inhibition of renal oxidative stress and TGF-β
Q37741787New pharmacological treatments for improving renal outcomes in diabetes
Q40757990Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells
Q36345732Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells
Q35162557Oryeongsan suppressed high glucose-induced mesangial fibrosis
Q54935923Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats.
Q31864674Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts
Q44311052Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding ph
Q43269412Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.
Q38111707Pathophysiology of the diabetic kidney.
Q44649164Peritoneal dialysis: diabetes of the peritoneal cavity
Q50795437Pharmacokinetics and Safety of DW1029M, a Botanical Drug for the Treatment of Diabetic Nephropathy, Following Single Doses in Healthy Subjects.
Q41440241Post-transplant diabetes mellitus. The role of immunosuppression
Q39126178Potential regulatory mechanisms of lncRNA in diabetes and its complications
Q44458242Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model
Q33637693Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways
Q37210162Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice
Q41882971Protective effect of magnesium on renal function in STZ-induced diabetic rats
Q34097328Protein kinase C activation and its pharmacological inhibition in vascular disease
Q35581300Proteinuria in diabetic nephropathy: treatment and evolution
Q37430721Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism.
Q34067504Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy
Q35909055Recent developments in epigenetics of acute and chronic kidney diseases
Q28205154Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms
Q36785571Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment
Q43099042Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans
Q37364519Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions
Q34726882Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions
Q37370688Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice
Q46091769Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts
Q38059670Role of epigenetic mechanisms in the vascular complications of diabetes.
Q40053242Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways
Q36547055Similarities and differences between alpha-tocopherol and gamma-tocopherol in amelioration of inflammation, oxidative stress and pre-fibrosis in hyperglycemia induced acute kidney inflammation
Q41643857Simvastatin ameliorates low-dose streptozotocin-induced type 2 diabetic nephropathy in an experimental rat model
Q42441608Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells
Q84010026Soy protein prevents renal damage in a fructose-induced model of metabolic syndrome via inhibition of NF-kB in male rats
Q35629267Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance.
Q42450892Suppressions of chronic glomerular injuries and TGF-β1production by HGF in attenuation of murine diabetic nephropathy
Q37347217TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
Q41469693TGF-beta in kidney fibrosis: a target for gene therapy
Q28367170TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy
Q37476582TGF-β/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1α expression
Q39418101TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition
Q39263423The Effects of Total Flavonoids from Buckwheat Flowers and Leaves on Renal Damage and PTP1B Expression in Type 2 Diabetic Rats
Q44650481The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1
Q59048778The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy
Q44791690The effects of smoking and its cessation on 8-epi-PGF2alpha and transforming growth factor-beta 1 in Type 1 diabetes mellitus.
Q37590421The genetics of diabetic nephropathy.
Q37209550The pathogenesis of diabetic nephropathy
Q24609124The role of epigenetics in the pathology of diabetic complications
Q34292435The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
Q54373570The role of vascular endothelial growth factor +405 G/C polymorphism and albuminuria in patients with type 2 diabetes mellitus.
Q53580895Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.
Q40606151Thrombospondin-1 mediates distal tubule hypertrophy induced by glycated albumin
Q44762884Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo
Q34355665Transforming growth factor β1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells
Q46717261Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells
Q28292776Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy
Q37716694Trends in advanced glycation end products research in diabetes mellitus and its complications.
Q36297539Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy
Q47757479Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy
Q77658807Ultrastructural examination of corneal epithelium of spontaneously obese, hyperglycemic rats
Q92030126Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa
Q35739805Use of genetic mouse models in the study of diabetic nephropathy
Q45147720Use of genetic mouse models in the study of diabetic nephropathy
Q37360457Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy
Q54791518Vitamin E and probucol reduce urinary lipophilic aldehydes and renal enlargement in streptozotocin-induced diabetic rats.
Q53153595Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling.
Q92272691miR-206 Inhibits Cell Proliferation and Extracellular Matrix Accumulation by Targeting Hypoxia-Inducible Factor 1-alpha (HIF-1α) in Mesangial Cells Treated with High Glucose

Search more.