The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis

scientific article published on 22 January 2010

The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2010.01.021
P932PMC publication ID3586736
P698PubMed publication ID20096777
P5875ResearchGate publication ID41122167

P50authorHan-Gon ChoiQ88992571
P2093author name stringKeon Wook Kang
Mi-Kyoung Kwak
Jung-Ae Kim
Thomas W Kensler
Sae Kwang Ku
Dae-Duk Kim
Sang Geon Kim
Kyeong-Ah Jung
Hyun-Min Park
Dong-ha Shin
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Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expressionQ39818094
Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cellsQ40395759
Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.Q40464612
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The transcription factor NRF2 protects against pulmonary fibrosisQ44945397
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The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosisQ46446511
Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cellsQ46458543
Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathwayQ46461935
Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway.Q53628663
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridineQ56879285
Lipid peroxidation accompanies cyclosporine nephrotoxicity: effects of vitamin EQ72242513
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Role of nitric oxide in cyclosporine A-induced hypertensionQ77580259
Dietary glycine and renal denervation prevents cyclosporin A-induced hydroxyl radical production in rat kidneyQ78172010
Cyclosporine nephrotoxicityQ94359952
Epithelial-mesenchymal transition and its implications for fibrosisQ24302042
The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegenerationQ24644214
Cellular and molecular mechanisms of fibrosisQ24648892
The basics of epithelial-mesenchymal transitionQ24652992
The epithelial-mesenchymal transition: new insights in signaling, development, and diseaseQ24683758
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
High-dose acetylcysteine in idiopathic pulmonary fibrosisQ28283438
Evidence that fibroblasts derive from epithelium during tissue fibrosisQ29616581
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrixQ29619797
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?Q33727178
Role of redox potential and reactive oxygen species in stress signalingQ33771754
Does cyclosporin A generate free radicals?Q33986234
Pharmacological and clinical aspects of heme oxygenaseQ34759206
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Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition.Q35085117
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosisQ35087744
Antioxidant nutrients protect against cyclosporine A nephrotoxicityQ35160383
Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouseQ35608869
Cyclosporine renal dysfunctionQ35711141
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulationQ36038160
Nox-2 is a modulator of fibrogenesis in kidney allograftsQ36611193
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanismQ36642707
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in miceQ36732083
Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosisQ36842403
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstructionQ36991087
Oxidant-antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosisQ37051317
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling PathwayQ37062266
Molecular mechanisms of Nrf2-mediated antioxidant responseQ37073173
N-acetylcysteine inhibits alveolar epithelial-mesenchymal transitionQ37421277
P433issue8
P304page(s)1051-1063
P577publication date2010-01-22
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleThe NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis
P478volume48

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