Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.

scientific article published on 22 October 2015

Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/JAPPLPHYSIOL.00721.2015
P698PubMed publication ID26494449
P5875ResearchGate publication ID283158108

P50authorChengcao SunQ86543265
P2093author name stringDejia Li
Shujun Li
P2860cites workA major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structureQ24562666
Cellular and molecular mechanisms of fibrosisQ24648892
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Recent progress in satellite cell/myoblast engraftment -- relevance for therapyQ27014183
Transforming growth factor beta in tissue fibrosisQ28239292
Gene and cell-mediated therapies for muscular dystrophy.Q33831193
Long-term blocking of calcium channels in mdx mice results in differential effects on heart and skeletal muscleQ34469185
Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic statesQ35110459
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseasesQ35649473
PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy.Q35666298
Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine.Q35753459
Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling PathwayQ35859481
Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy.Q36414153
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosisQ36652097
Molecular basis for chemoprevention by sulforaphane: a comprehensive review.Q36775326
Emerging role of Nrf2 in protecting against hepatic and gastrointestinal diseaseQ36846919
Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerationsQ36921222
Transforming growth factor-beta and myostatin signaling in skeletal muscleQ37011013
Therapeutic advances in muscular dystrophyQ37455625
Targeting fibrosis in Duchenne muscular dystrophyQ37770947
The Nrf2 system as a potential target for the development of indirect antioxidants.Q37802176
Repair or replace? Exploiting novel gene and cell therapy strategies for muscular dystrophiesQ38079633
Pharmacological prospects in the treatment of Duchenne muscular dystrophyQ38133306
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signalingQ39431057
Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy.Q39528770
Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginoneQ39955104
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathwayQ41298517
PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overloadQ42406946
Localization and early time course of TGF-beta 1 mRNA expression in dystrophic muscleQ45076412
Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginoneQ46761904
Temporal and spatial mRNA expression patterns of TGF-beta1, 2, 3 and TbetaRI, II, III in skeletal muscles of mdx mice.Q54625653
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)377-390
P577publication date2015-10-22
P1433published inJournal of Applied PhysiologyQ1091719
P1476titleSulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.
P478volume120

Reverse relations

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