Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review

scientific article published on 22 July 2019

Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2019.00805
P932PMC publication ID6661542
P698PubMed publication ID31396083

P2093author name stringLin Wang
Jin Wang
Qian Ran
Hai-Rong Zeng
Qin-Wan Huang
Xiang-Bo Yang
P2860cites workSerum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetesQ24309211
Insulin and insulin resistance.Q24532776
The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological researchQ26851917
Rhizoma Coptidis: A Potential Cardiovascular Protective AgentQ28067054
San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A ReviewQ28075782
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Endothelial nitric oxide synthase in vascular disease: from marvel to menaceQ28305279
Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic GluconeogenesisQ28477076
Berberine promotes glucose consumption independently of AMP-activated protein kinase activationQ28541332
Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGFβ1-PI3K/AKT pathwayQ49602918
The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial KATP channel.Q49853562
Tackling dipeptidyl peptidase IV in neurological disordersQ49940117
Effects of palmatine on rats with comorbidity of diabetic neuropathic pain and depressionQ50049980
Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC PathwayQ50089534
Effects of berberine on mRNA expression levels of PPARγ and adipocytokines in insulin-resistant adipocytesQ50124025
Regulations of berberine on gene expression of BMP4 transcriptional pathways to improve visceral white adipose tissues insulin resistance in type 2 diabetic hamstersQ50226747
Berberine reduced blood pressure and improved vasodilation in diabetic ratsQ50640205
Berberine chloride improved synaptic plasticity in STZ induced diabetic rats.Q50746082
Runx2 Controls Bone Resorption through the Down-Regulation of the Wnt Pathway in Osteoblasts.Q50908319
Effects of type 2 diabetes mellitus on the pharmacokinetics of berberine in ratsQ51019283
An activity-integrated strategy involving ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and fraction collector for rapid screening and characterization of the α-glucosidase inhibitors in Coptis chinensis FrQ51062237
Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathyQ51191631
Berberine regulates glycemia via local inhibition of intestinal dipeptidyl peptidase-ⅣQ51273832
Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction modelQ84561983
Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cellsQ85035223
Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studiesQ85263601
Screening for potential -α -Glucosidase inhibitors in Coptis chinensis franch extract using ultrafiltration LC-ESI-MSnQ86023429
Propionic and butyric acids, formed in the caecum of rats fed highly fermentable dietary fibre, are reflected in portal and aortic serumQ86493364
Renoprotective effects of berberine and its potential effect on the expression of β-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy ratsQ86619116
Renoprotective effect of berberine on type 2 diabetic nephropathy in ratsQ87103959
Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathyQ87216947
Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K-Akt signaling in diabetic ratsQ87512678
The renoprotective effects of berberine via the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in ratsQ87923423
Ameliorating effect of berbamine on hepatic key enzymes of carbohydrate metabolism in high-fat diet and streptozotocin induced type 2 diabetic ratsQ88423165
[Hypolipidemic effect of Coptis chinensis and C. deltoidea on type 2 diabetes rats through SCAP/SREBP-1c signal pathway]Q89201578
Diabetic dyslipidaemiaQ89261937
Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic ratsQ89342699
Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic studyQ89414548
Dietary polyphenols and type 2 diabetes: Human Study and Clinical TrialQ89546796
Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathyQ90288268
Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3Q90995304
DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathwayQ91095879
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β PathwayQ91270835
Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosisQ91484775
Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacityQ93161669
Tetrahydroxy stilbene glucoside protected against diabetes-induced osteoporosis in mice with streptozotocin-induced hyperglycemiaQ93233158
Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubesQ95481807
Hypoglycemic activity of alkaloidal fraction of Tinospora cordifoliaQ39526185
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expressionQ39792130
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase.Q39878461
Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expressionQ39908313
Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappaB activationQ40140380
Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell lineQ40263277
Protective effect of Coptidis Rhizoma on S-nitroso-N-acetylpenicillamine (SNAP)-induced apoptosis and necrosis in pancreatic RINm5F cells.Q40482420
Myocardial Salvaging Effects of Berberine in Experimental Diabetes Co-Existing with Myocardial InfarctionQ40571635
Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized ratsQ41656785
Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivoQ41841136
Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy.Q41854992
RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular ComplicationQ41932557
Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.Q42767408
Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ.Q42797989
The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic miceQ42810100
Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytesQ42820205
Protective effect of berberine on renal fibrosis caused by diabetic nephropathyQ42835125
Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathwayQ42963879
Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro studyQ43129958
Increased plasma exposures of five protoberberine alkaloids from Coptidis Rhizoma in streptozotocin-induced diabetic rats: is P-GP involved?Q43182248
Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocinQ43290690
Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathyQ43442147
Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic ratsQ43635628
Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathwayQ44036628
The involvement of P-glycoprotein in berberine absorptionQ44279883
Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarctionQ44304785
Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic ratsQ44331287
Impaired gastric emptying and altered intragastric meal distribution in diabetes mellitus related to autonomic neuropathy?Q44488564
Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-κB/AP-1 pathwaysQ44578386
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural productQ44652622
Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products.Q45000524
The anti-diabetic effects and pharmacokinetic profiles of berberine in mice treated with Jiao-Tai-Wan and its compatibilityQ45265855
Effects of berberine on expression of hepatocyte nuclear factor 4alpha and glucokinase activity in mouse primary hepatocytesQ46152611
Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose conditionQ46163975
Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus.Q46199809
Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductaseQ46235160
Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signalingQ46480430
Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay MiceQ46568863
Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extractQ46582470
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionQ46745033
Synthesis and antihyperglycemic evaluation of various protoberberine derivativesQ46855401
Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic ratsQ46914648
New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the "Bacteria-Mucosal Immunity-Inflammation-Diabetes" Axis.Q47108560
Interaction between bone and glucose metabolism [Review].Q47718312
Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cellsQ47811968
The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activationQ47853318
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db MiceQ47939966
Influence of quercetin, naringenin and berberine on glucose transporters and insulin signalling molecules in brain of streptozotocin-induced diabetic ratsQ47983181
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetesQ48157980
Dual-target screening of bioactive components from traditional Chinese medicines by hollow fiber-based ligand fishing combined with liquid chromatography-mass spectrometryQ48757994
Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohortQ48769554
Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in ratsQ48925203
Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programsQ38341518
Berberine Pretreatment Confers Cardioprotection Against Ischemia-Reperfusion Injury in a Rat Model of Type 2 DiabetesQ38410398
Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5'-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cellsQ38411498
Natural Products for the Treatment of Type 2 Diabetes MellitusQ38541528
Comparative pharmacokinetics of six major bioactive components in normal and type 2 diabetic rats after oral administration of Sanhuang Xiexin Decoction extracts by UPLC-TQ MS/MS.Q38653421
Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective.Q38689745
Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR-106b Expression and Up-Regulating SIRT1.Q38706356
α-Glucosidase and α-amylase inhibitors from seed oil: A review of liposoluble substance to treat diabetesQ38725795
Berberine induces GLP-1 secretion through activation of bitter taste receptor pathwaysQ38849837
Modifications of dietary flavonoids towards improved bioactivity: An update on structure-activity relationship.Q38903422
Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells.Q38984783
Effects of high glucose and high insulin concentrations on osteoblast function in vitroQ38991825
Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth.Q39108936
Oxidative stress and diabetic retinopathy: development and treatmentQ39269643
Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndromeQ39430910
Anti-diabetic effect of Coptis Chinensis polysaccharide in high-fat diet with STZ-induced diabetic miceQ39490230
Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 PathwayQ28550972
Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic ratsQ28584189
A metagenome-wide association study of gut microbiota in type 2 diabetesQ29547726
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in miceQ29615055
Oxidative Stress and Diabetic ComplicationsQ29615423
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeabilityQ29617378
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubesQ30738352
Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adultsQ33423654
7-Chloroarctinone-b as a new selective PPARgamma antagonist potently blocks adipocyte differentiationQ33493877
Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cellsQ33655566
Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinaseQ33677858
Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM RatsQ33766908
Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse isletsQ33842742
Decreased gastric motility in type II diabetic patientsQ34043578
Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancerQ34087341
Clinical review 124: Diabetic dyslipidemia: causes and consequencesQ34174659
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acidsQ34211573
Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathwaysQ34371949
Alkaloids as aldose reductase inhibitors, with special reference to berberineQ34385368
Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy modelsQ34399505
Update on diabetes classificationQ34451220
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleQ34452979
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjectsQ34538317
Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucoseQ34777983
Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase.Q34808178
Tissue distribution of berberine and its metabolites after oral administration in ratsQ35035856
Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery diseaseQ35240672
Pathophysiology of diabetic dyslipidaemia: where are we?Q35350326
Endothelial nitric oxide synthase and endothelial dysfunction.Q35574173
Transforming berberine into its intestine-absorbable form by the gut microbiotaQ35691271
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in ratsQ35784335
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic ratsQ35819543
Pathogenesis of type 2 diabetes mellitusQ35861736
Renoprotective effect of berberine via regulating the PGE2 -EP1-Gαq-Ca(2+) signalling pathway in glomerular mesangial cells of diabetic ratsQ35995332
Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolismQ36345197
Berberine inhibits cardiac fibrosis of diabetic ratsQ51278680
Coptis chinensis Polysaccharides Inhibit Advanced Glycation End Product Formation.Q51285749
Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in ratsQ51299721
Antidiabetic mechanism of Coptis chinensis polysaccharide through its antioxidant property involving the JNK pathwayQ51305000
Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathyQ51347304
Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic ratsQ51348247
Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trialQ51382786
The potential beneficial effects of phenolic compounds isolated from A. pilosa Ledeb on insulin-resistant hepatic HepG2 cellsQ51430671
Effects and underlying mechanism of berberine on renal tubulointerstitial injury in diabetic ratsQ51748373
Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk.Q53110705
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse modelQ53578000
Berberine, an isoquinoline alkaloid, inhibits streptozotocin-induced apoptosis in mouse pancreatic islets through down-regulating Bax/Bcl-2 gene expression ratioQ54312577
BK Channels in the Vascular SystemQ54393122
Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β-cells via TLR4-independent JNK/NF-κB pathwayQ54399267
Prorenin, Renin, and their receptor: moving targetsQ54688101
Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway.Q55108878
Cellular stress response mechanisms of Rhizoma coptidis: a systematic review.Q55274553
Poor permeability and absorption affect the activity of four alkaloids from CoptisQ57106142
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cellsQ58597909
Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese miceQ58700647
The total alkaloids from Franch improve cognitive deficits in type 2 diabetic ratsQ58781641
Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'Q58803102
Molecular Modulation of Osteoblasts and Osteoclasts in Type 2 DiabetesQ59806788
Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the BioavailabilityQ61454313
Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicologyQ64064784
Bidirectional regulation of adenosine 5'-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration.Q64941870
Diabetes mellitus is associated with insufficient microvascular reperfusion following revascularization for anterior acute myocardial infarctionQ73705940
GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complicationsQ77844995
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin releaseQ79750060
Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validationQ79763647
Berberine alleviates ischemic arrhythmias via recovering depressed Ito and ICa currents in diabetic ratsQ83089525
Isoquinoline Alkaloids from Tinospora cordifolia Inhibit Rat Lens Aldose ReductaseQ83372364
Berberine acutely inhibits the digestion of maltose in the intestineQ84211238
Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in MiceQ36410673
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).Q36457102
Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption.Q36458647
Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienesQ36476651
Modulating gut microbiota as an anti-diabetic mechanism of berberineQ36516516
Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolismQ36674722
Effect of Berberine on PPARα/NO Activation in High Glucose- and Insulin-Induced Cardiomyocyte HypertrophyQ36739688
Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone developmentQ36768663
Glucokinase activators for diabetes therapy: May 2010 status reportQ36783849
Therapy in the Early Stage: IncretinsQ36783865
Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cellsQ36790209
Berberine improves mesenteric artery insulin sensitivity through up-regulating insulin receptor-mediated signalling in diabetic ratsQ36830141
Beneficial Effects of Berberine on Oxidized LDL-Induced Cytotoxicity to Human Retinal Müller CellsQ37126456
Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic MiceQ37210162
Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the EndotheliumQ37231719
Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberineQ37238931
Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetesQ37370197
Berberine protects against palmitate-induced endothelial dysfunction: involvements of upregulation of AMPK and eNOS and downregulation of NOX4.Q37412690
Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic RatsQ37622726
Peroxisome proliferator-activated receptor translational research and clinical experienceQ37634781
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubineQ37688749
Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytesQ37716355
Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy miceQ37741992
Müller Glia: A Promising Target for Therapeutic RegenerationQ37908859
Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation.Q37912391
Bone, sweet bone--osteoporotic fractures in diabetes mellitus.Q37976305
Antidiabetic Properties of Berberine: From Cellular Pharmacology to Clinical EffectsQ38012073
Mechanisms of diabetic complications.Q38072902
An Insight into the Recent Diabetes Trials: What is the Best Approach to Prevent Macrovascular and Microvascular Complications?Q38122398
Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms.Q38122978
Diabetes, oxidative stress and therapeutic strategiesQ38218198
Ca(2+) handling alterations and vascular dysfunction in diabetesQ38248928
Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silicoQ38297767
Berberine-Improved Visceral White Adipose Tissue Insulin Resistance Associated with Altered Sterol Regulatory Element-Binding Proteins, Liver X Receptors, and Peroxisome Proliferator-Activated Receptors Transcriptional Programs in Diabetic HamstersQ38335523
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjecttype 2 diabetesQ3025883
P304page(s)805
P577publication date2019-07-22
P13046publication type of scholarly workreview articleQ7318358
P1433published inFrontiers in PharmacologyQ2681208
P1476titleRhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review
P478volume10